Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Steven J, Sandler"'
Autor:
Alexander T. Duckworth, Peter L. Ducos, Sarah D. McMillan, Kenneth A. Satyshur, Katelien H. Blumenthal, Haley R. Deorio, Joseph A. Larson, Steven J. Sandler, Timothy Grant, James L. Keck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Bacterial replisomes often dissociate from replication forks before chromosomal replication is complete. To avoid the lethal consequences of such situations, bacteria have evolved replication restart pathways that reload replisomes onto prem
Externí odkaz:
https://doaj.org/article/d87d4d29ec3c4872add4e4d438a85a10
Autor:
Jennifer M. Hayashi, Kirill Richardson, Emily S. Melzer, Steven J. Sandler, Bree B. Aldridge, M. Sloan Siegrist, Yasu S. Morita
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
ABSTRACT Cell elongation occurs primarily at the mycobacterial cell poles, but the molecular mechanisms governing this spatial regulation remain elusive. We recently reported the presence of an intracellular membrane domain (IMD) that was spatially s
Externí odkaz:
https://doaj.org/article/d4024532b5e649359bab4c5e0edff90c
Publikováno v:
Mol Microbiol
In Escherichia coli, PriA, PriB, PriC, and DnaT proteins mediate three pathways for Replication Restart called PriA-PriB, PriA-PriC and PriC. PriA is crucial for two of the three pathways. Its absence leads to slow growth, high basal levels of SOS ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2c9da51a1920ebd8af10236966186d
https://doi.org/10.1111/mmi.14802
https://doi.org/10.1111/mmi.14802
Autor:
Steven Van Alstine, Steven J. Sandler
Publikováno v:
Journal of Bacteriology. 204
In Escherichia coli K-12, SOS constitutive (SOS C ) mutants of recA turn on the SOS response in the absence of DNA damage. Some SOS C mutants are also able to indirectly suppress the UV sensitivity of recF mutations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcc623322d6d368dc0b9acc2e5ecef8e
https://doi.org/10.1128/jb.00081-22
https://doi.org/10.1128/jb.00081-22
Publikováno v:
Genetics. 216:381-393
RecA is essential for double-strand-break repair (DSBR) and the SOS response in Escherichia coli K-12. RecN is an SOS protein and a member of the Structural Maintenance of Chromosomes family of proteins thought to play a role in sister chromatid cohe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::893a8d82fbd23ec674878a3031ecd233
https://doi.org/10.1534/genetics.120.303476
https://doi.org/10.1534/genetics.120.303476
Autor:
Steven J. Sandler, Antoine M. van Oijen, Nicholas E. Dixon, Lisanne M. Spenkelink, James L. Keck, Alexander G. Kozlov, Michael M. Cox, Elizabeth A. Wood, Timothy M. Lohman, Katarzyna Dubiel, Slobodan Jergic, Camille Henry
Publikováno v:
Nucleic Acids Research
Bacterial single-stranded DNA-binding proteins (SSBs) bind single-stranded DNA and help to recruit heterologous proteins to their sites of action. SSBs perform these essential functions through a modular structural architecture: the N-terminal domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64bca514e517b9ed299927f5f7d68b4
https://doi.org/10.1093/nar/gkaa320
https://doi.org/10.1093/nar/gkaa320
Autor:
Taejin Kim, Sindhu Chitteni-Pattu, Benjamin L Cox, Elizabeth A Wood, Steven J Sandler, Michael M Cox
Publikováno v:
PLoS Genetics, Vol 11, Iss 6, p e1005278 (2015)
The recombination activity of Escherichia coli (E. coli) RecA protein reflects an evolutionary balance between the positive and potentially deleterious effects of recombination. We have perturbed that balance, generating RecA variants exhibiting impr
Externí odkaz:
https://doaj.org/article/830360c6348141fea78549db025ec0a1
Publikováno v:
Journal of Biological Chemistry. 294:2801-5614
DNA helicases are motor proteins that couple the chemical energy of nucleoside triphosphate hydrolysis to the mechanical functions required for DNA unwinding. Studies of several helicases have identified strand-separating “pin” structures that ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ecea143f00e092bd2040b25ecb971f
https://doi.org/10.1074/jbc.ra118.006870
https://doi.org/10.1074/jbc.ra118.006870
Autor:
Steven J Sandler
Publikováno v:
eLife, Vol 3 (2014)
In vitro evolution experiments reveal that single mutations in three genes can increase the ability of E. coli to survive ionizing radiation by a factor of 1000.
Externí odkaz:
https://doaj.org/article/3188fd68b0624930b56fd1a572b06c09
Publikováno v:
Molecular Microbiology. 111:405-422
In Escherichia coli, after DNA damage, the SOS response increases the transcription (and protein levels) of approximately 50 genes. As DNA repair ensues, the level of transcription returns to homeostatic levels. ClpXP and other proteases return the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38555b5ffecc11d3ac56db765d4bd7c2
https://doi.org/10.1111/mmi.14162
https://doi.org/10.1111/mmi.14162