Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Steven J, Kunnen"'
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Akademický článek
Identifying multiscale translational safety biomarkers using a network-based systems approach
Autor: Giulia Callegaro, Johannes P. Schimming, Janet Piñero González, Steven J. Kunnen, Lukas Wijaya, Panuwat Trairatphisan, Linda van den Berk, Kim Beetsma, Laura I. Furlong, Jeffrey J. Sutherland, Jennifer Mollon, James L. Stevens, Bob van de Water
Publikováno v: iScience, Vol 26, Iss 3, Pp 106094- (2023)
Summary: Animal testing is the current standard for drug and chemicals safety assessment, but hazards translation to human is uncertain. Human in vitro models can address the species translation but might not replicate in vivo complexity. Herein, we
Externí odkaz: https://doaj.org/article/c1ec17ac979040d09bc96f5bae7f9e91
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2
Akademický článek
An ensemble learning approach for modeling the systems biology of drug-induced injury
Autor: Joaquim Aguirre-Plans, Janet Piñero, Terezinha Souza, Giulia Callegaro, Steven J. Kunnen, Ferran Sanz, Narcis Fernandez-Fuentes, Laura I. Furlong, Emre Guney, Baldo Oliva
Publikováno v: Biology Direct, Vol 16, Iss 1, Pp 1-14 (2021)
Abstract Background Drug-induced liver injury (DILI) is an adverse reaction caused by the intake of drugs of common use that produces liver damage. The impact of DILI is estimated to affect around 20 in 100,000 inhabitants worldwide each year. Despit
Externí odkaz: https://doaj.org/article/f3a04f85cfdc43a285f9e1510aef32f2
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3
Systematic comparison of temporal transcriptional responses to hepatotoxicants in primary human hepatocytes and HepaRG cells using concentration-response modelling of gene co-expression networks
Autor: Steven J. Kunnen, Emma Arnesdotter, Christian Tobias Willenbockel, Mathieu Vinken, Bob van de Water
Next generation risk assessment of chemicals revolves around the use of mechanistic information without animal experimentation. In this regard, toxicogenomics has proven to be a useful tool to elucidate the underlying mechanisms of adverse effects of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9161d3ac897feeab8d5d53b2d478bf5
https://doi.org/10.1101/2023.02.01.526628
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6
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid
Autor: Nanette G, Vrijenhoek, Matthias M, Wehr, Steven J, Kunnen, Lukas S, Wijaya, Giulia, Callegaro, Martijn J, Moné, Sylvia E, Escher, Bob, Van de Water
Publikováno v: ALTEX : Alternatives to Animal Experimentation
ALTEX
Chemical read-across is commonly evaluated without particular knowledge of the biological mechanisms leading to observed adverse outcomes in vivo. Integrating data that indicate shared modes of action in humans will strengthen read-across cases. Here
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e2256765890ee51972b634035aa790
http://hdl.handle.net/1887/3279365
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7
The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment
Autor: Steven J. Kunnen, Marije Niemeijer, Giulia Callegaro, Laura I. Furlong, Jeffrey J. Sutherland, Janet Piñero Gonzalez, Wouter den Hollander, Panuwat Trairatphisan, Bob van de Water, Yue Webster, Emre Guney, James L. Stevens, Julio Saez-Rodriguez, Jennifer Mollon, Solène Grosdidier
Publikováno v: Archives of Toxicology, 95(12), 3745-3775. Springer-Verlag
Archives of Toxicology
Archives of Toxicology, 95(12), 3745-3775
Mechanism-based risk assessment is urged to advance and fully permeate into current safety assessment practices, possibly at early phases of drug safety testing. Toxicogenomics is a promising source of mechanisms-revealing data, but interpretative an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae839152101c7c0d415360667759ecf
https://pure.eur.nl/en/publications/b57c4814-0350-4abf-9941-fb822553e7c6
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9
An ensemble learning approach for modeling the systems biology of drug-induced injury
Autor: Giulia Callegaro, Ferran Sanz, Narcis Fernandez-Fuentes, Janet Piñero, Terezinha Souza, Joaquim Aguirre-Plans, Steven J. Kunnen, Laura I. Furlong, Baldo Oliva, Emre Guney
Publikováno v: Biology Direct
Biology Direct, 16(1):5. BioMed Central
Biology Direct, Vol 16, Iss 1, Pp 1-14 (2021)
Background: Drug-induced liver injury (DILI) is an adverse reaction caused by the intake of drugs of common use that produces liver damage. The impact of DILI is estimated to affect around 20 in 100,000 inhabitants worldwide each year. Despite being
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9434845d0f3447c38de46afd28a285f8
http://europepmc.org/articles/PMC7805064
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10
Comprehensive transcriptome analysis of fluid shear stress altered gene expression in renal epithelial cells
Autor: Tareq B. Malas, C.M. Semeins, Dorien J.M. Peters, Steven J. Kunnen, Astrid D. Bakker
Publikováno v: Journal of Cellular Physiology, 233(4), 3615-3628. Wiley-Liss Inc.
Journal of Cellular Physiology, 233(4), 3615-3628
Kunnen, S J, Malas, T B, Semeins, C M, Bakker, A D & Peters, D J M 2018, ' Comprehensive transcriptome analysis of fluid shear stress altered gene expression in renal epithelial cells ', Journal of Cellular Physiology, vol. 233, no. 4, pp. 3615-3628 . https://doi.org/10.1002/jcp.26222
Journal of Cellular Physiology
Renal epithelial cells are exposed to mechanical forces due to flow-induced shear stress within the nephrons. Shear stress is altered in renal diseases caused by tubular dilation, obstruction, and hyperfiltration, which occur to compensate for lost n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4726b9c4a87e9d702906ad6be69d480
https://doi.org/10.1002/jcp.26222
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