Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Steven J, Canipa"'
Autor:
Rachael E. Tennant, Richard V. Williams, Masamitsu Honma, Alex Cayley, Kenichi Masumura, Susanne A. Stalford, Sebastien J. Guesne, Steven J. Canipa, William C. Drewe, Takeshi Morita
Publikováno v:
Mutagenesis. 34:111-121
As part of the hazard and risk assessment of chemicals in man, it is important to assess the ability of a chemical to induce mutations in vivo. Because of the commonalities in the molecular initiating event, mutagenicity in vitro can correlate well t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae0aa8a2ab56cab0be5c9413aa96373
https://doi.org/10.1093/mutage/gey030
https://doi.org/10.1093/mutage/gey030
Autor:
Rachael E. Tennant, Devin O'Brien, Thomas Steger-Hartmann, Jonathan D. Vessey, Steven J. Canipa, Ann De Smedt, Rachel Hemingway, Angela White, Martyn L. Chilton, Rahul Parakhia, Sylvain Etter, Jeffrey Plante, Jedd Hillegass, Janet Gould, Alun Myden, Paul Sterchele, Donna S. Macmillan, B. Smith
Publikováno v:
Journal of Applied Toxicology. 37:985-995
Dermal contact with chemicals may lead to an inflammatory reaction known as allergic contact dermatitis. Consequently, it is important to assess new and existing chemicals for their skin sensitizing potential and to mitigate exposure accordingly. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2817357adcea70dfa0e1443634f86d91
https://doi.org/10.1002/jat.3448
https://doi.org/10.1002/jat.3448
Autor:
Lilia Fisk, Valerie J. Gillet, William C. Drewe, Mukesh Patel, Jonathan D. Vessey, Steven J. Canipa, Laurence Coquin, Richard Sherhod, Jeffrey Plante
Publikováno v:
Toxicology Research. 4:46-56
Emerging pattern mining techniques have been applied to datasets of Ames mutagens. The discovered patterns give rise to clusters of compounds from large and biased datasets which are used to develop new structural alerts for mutagenicity in the Derek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cebc49df912ce02f0bcbd51dac353a29
https://doi.org/10.1039/c4tx00071d
https://doi.org/10.1039/c4tx00071d
Publikováno v:
Angewandte Chemie (International ed. in English). 57(1)
An 8-step, gram-scale synthesis of the (-)-sparteine surrogate (22 % yield, with just 3 chromatographic purifications) and a 10-step, gram-scale synthesis of (-)-sparteine (31 % yield) are reported. Both syntheses proceed with complete diastereocontr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cadac6858c823c5cfc1faf6cfbf39e8
https://pubmed.ncbi.nlm.nih.gov/29155468
https://pubmed.ncbi.nlm.nih.gov/29155468
Publikováno v:
Tetrahedron. 70:7395-7403
Four new copper(II)/diamine complexes comprising some (+)-sparteine surrogates and a cyclohexane-derived diamine were prepared and evaluated as chiral catalysts in desymmetrisation of meso-diols and asymmetric Henry reactions. Mono-benzoylation react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c84bbdae0fcc7337270c6e18013fb3ad
https://doi.org/10.1016/j.tet.2014.06.117
https://doi.org/10.1016/j.tet.2014.06.117
Autor:
Steven J, Canipa, Martyn L, Chilton, Rachel, Hemingway, Donna S, Macmillan, Alun, Myden, Jeffrey P, Plante, Rachael E, Tennant, Jonathan D, Vessey, Thomas, Steger-Hartmann, Janet, Gould, Jedd, Hillegass, Sylvain, Etter, Benjamin P C, Smith, Angela, White, Paul, Sterchele, Ann, De Smedt, Devin, O'Brien, Rahul, Parakhia
Publikováno v:
Journal of applied toxicology : JAT. 37(8)
Dermal contact with chemicals may lead to an inflammatory reaction known as allergic contact dermatitis. Consequently, it is important to assess new and existing chemicals for their skin sensitizing potential and to mitigate exposure accordingly. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb6b994eafdb2f3099447f035ba1c46c
https://pubmed.ncbi.nlm.nih.gov/28244128
https://pubmed.ncbi.nlm.nih.gov/28244128
Autor:
Steven J. Canipa, Donna S. Macmillan, Martyn L. Chilton, Barber Christopher Gordon, Richard V. Williams
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 76
There is a pressing need for non-animal methods to predict skin sensitisation potential and a number of in chemico and in vitro assays have been designed with this in mind. However, some compounds can fall outside the applicability domain of these in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5473449a17c5bbc67b71c4eff51186a1
https://pubmed.ncbi.nlm.nih.gov/26796566
https://pubmed.ncbi.nlm.nih.gov/26796566
Publikováno v:
The Journal of Organic Chemistry. 76:4794-4799
A new protocol for the catalytic asymmetric deprotonation of a phosphine borane using s-BuLi and substoichiometric quantities of chiral diamines is reported. The method involves three sequential additions of s-BuLi, and use of (-)-sparteine or the (+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98ef9fee45b49d820ab7f588b8279d5
https://doi.org/10.1021/jo200708e
https://doi.org/10.1021/jo200708e
Publikováno v:
Toxicology Letters. 295:S174
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73e772e13a46edaa65896fd23f616067
https://doi.org/10.1016/j.toxlet.2018.06.813
https://doi.org/10.1016/j.toxlet.2018.06.813
Publikováno v:
Tetrahedron: Asymmetry. 20:2407-2412
The catalytic asymmetric deprotonation of tert-butyldimethylphosphine borane using s-BuLi or n-BuLi and sub-stoichiometric amounts of (−)-sparteine under one-ligand and two-ligand manifolds has been investigated. Using s-BuLi, slightly higher enant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d9946e7394a73545d956edbbd01fd61
https://doi.org/10.1016/j.tetasy.2009.10.002
https://doi.org/10.1016/j.tetasy.2009.10.002