Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Steven J, Altschuler"'
Small molecule in situ resin capture provides a compound first approach to natural product discovery
Autor:
Alexander Bogdanov, Mariam N. Salib, Alexander B. Chase, Heinz Hammerlindl, Mitchell N. Muskat, Stephanie Luedtke, Elany Barbosa da Silva, Anthony J. O’Donoghue, Lani F. Wu, Steven J. Altschuler, Tadeusz F. Molinski, Paul R. Jensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Culture-based microbial natural product discovery strategies fail to realize the extraordinary biosynthetic potential detected across earth’s microbiomes. Here we introduce Small Molecule In situ Resin Capture (SMIRC), a culture-independen
Externí odkaz:
https://doaj.org/article/7ba9d42708bb45c1a8547a7ae7e75601
A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113260- (2023)
Summary: Mechanisms that prevent accidental activation of the PINK1/Parkin mitophagy circuit on healthy mitochondria are poorly understood. On the surface of damaged mitochondria, PINK1 accumulates and acts as the input signal to a positive feedback
Externí odkaz:
https://doaj.org/article/1d17bce4d0a144888d732b6de877c34a
Publikováno v:
eLife, Vol 12 (2023)
The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic organisms and requires a molecular oxygen sensor. The prototypical sensor is the oxygen-dependent enzyme PHD: hypoxia inhibits its ability to hydroxylate th
Externí odkaz:
https://doaj.org/article/c4c9979e2d5f41528e4321ca0ea7b27f
Autor:
Capria Rinaldi, Christopher S. Waters, Zizheng Li, Karl Kumbier, Lee Rao, R. Jeremy Nichols, Matthew P. Jacobson, Lani F. Wu, Steven J. Altschuler
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112447- (2023)
Summary: Parkinson’s disease-causing leucine-rich repeat kinase 2 (LRRK2) mutations lead to varying degrees of Rab GTPase hyperphosphorylation. Puzzlingly, LRRK2 GTPase-inactivating mutations—which do not affect intrinsic kinase activity—lead t
Externí odkaz:
https://doaj.org/article/96865a93efde46f3a41eee3b34861ca1
Autor:
Jake M. Bieber, Laura E. Sanman, Xiaoxiao Sun, Heinz Hammerlindl, Feng Bao, Maike A. Roth, Megan L. Koleske, Liusheng Huang, Fran Aweeka, Lani F. Wu, Steven J. Altschuler
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Bieber et al use intestinal monolayers derived from fresh murine crypts as a model system to study drug toxicity. Testing 48 oncology drugs with known gastrointestinal toxicity as a proof of concept, they discover differential responses in cells from
Externí odkaz:
https://doaj.org/article/41ed1bb6411d4d969ca1025fa3f04d80
Autor:
Friedrich Stölzel, Sarah E. Fordham, Devi Nandana, Wei-Yu Lin, Helen Blair, Claire Elstob, Hayden L. Bell, Brigitte Mohr, Leo Ruhnke, Desiree Kunadt, Claudia Dill, Daniel Allsop, Rachel Piddock, Emmanouela-Niki Soura, Catherine Park, Mohd Fadly, Thahira Rahman, Abrar Alharbi, Manja Wobus, Heidi Altmann, Christoph Röllig, Lisa Wagenführ, Gail L. Jones, Tobias Menne, Graham H. Jackson, Helen J. Marr, Jude Fitzgibbon, Kenan Onel, Manja Meggendorfer, Amber Robinson, Zuzanna Bziuk, Emily Bowes, Olaf Heidenreich, Torsten Haferlach, Sara Villar, Beñat Ariceta, Rosa Ayala Diaz, Steven J. Altschuler, Lani F. Wu, Felipe Prosper, Pau Montesinos, Joaquin Martinez-Lopez, Martin Bornhäuser, James M. Allan
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Precision medicine can significantly improve outcomes for patients with cancer, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here, we describe somatic biallelic TET
Externí odkaz:
https://doaj.org/article/099cf4b757194708b07592874d0436b2
Publikováno v:
PLoS Genetics, Vol 17, Iss 11 (2021)
A fascinating question in neuroscience is how ensembles of neurons, originating from different locations, extend to the proper place and by the right time to create precise circuits. Here, we investigate this question in the Drosophila visual system,
Externí odkaz:
https://doaj.org/article/93927ab673724840b11ce01ebb009188
Publikováno v:
ACS chemical biology, vol 18, iss 4
High-content microscopy offers a scalable approach to screen against multiple targets in a single pass. Prior work has focused on methods to select “optimal” cellular readouts in microscopy screens. However, methods to select optimal cell line mo
Autor:
Ilgen Mender, Ryan LaRanger, Krishna Luitel, Michael Peyton, Luc Girard, Tsung-Po Lai, Kimberly Batten, Crystal Cornelius, Maithili P. Dalvi, Michael Ramirez, Wenting Du, Lani F. Wu, Steven J. Altschuler, Rolf Brekken, Elisabeth D. Martinez, John D. Minna, Woodring E. Wright, Jerry W. Shay
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 8, Pp 826-837 (2018)
Standard and targeted cancer therapies for late-stage cancer patients almost universally fail due to tumor heterogeneity/plasticity and intrinsic or acquired drug resistance. We used the telomerase substrate nucleoside precursor, 6-thio-2′-deoxygua
Externí odkaz:
https://doaj.org/article/4cb2a9b75e64451da5d6b5d27e43a411
Autor:
Lani F. Wu, Steven J. Altschuler, John D. Minna, Leandro Cerchietti, Fengtian Xue, Kimberley Avila, Long Shan Li, Rossella Marullo, Patrick D. Dospoy, Jill E. Larsen, Satwik Rajaram, Dhruba Deb
Legends for the supplementary figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a93791b8a915f365bb44e25737b682e
https://doi.org/10.1158/0008-5472.22413800.v1
https://doi.org/10.1158/0008-5472.22413800.v1