Zobrazeno 1 - 10
of 254
pro vyhledávání: '"Steven Idell"'
Autor:
Xia Guo, Christudas Sunil, Oluwaseun Adeyanju, Andrew Parker, Steven Huang, Mitsuo Ikebe, Torry A. Tucker, Steven Idell, Guoqing Qian
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Programmed death ligand-1 (PD-L1) is an immune checkpoint protein that has been linked with idiopathic pulmonary fibrosis (IPF) and fibroblast to myofibroblast transition (FMT). However, it remains largely unclear how PD-L1 mediates this pro
Externí odkaz:
https://doaj.org/article/667488909e5243a09413f200f51eb72e
Autor:
Fan Yang, Li Liu, Pierre Fernand Neuenschwander, Steven Idell, Ramakrishna Vankayalapati, Krishan Gopal Jain, Ke Du, Honglong Ji, Guohua Yi
Publikováno v:
ACS Omega, Vol 7, Iss 4, Pp 3203-3211 (2021)
Externí odkaz:
https://doaj.org/article/63782f62d82f4086b9c9d8eec4733faa
Autor:
Bock-Gie Jung, Kristin Dean, Carly Wadle, Buka Samten, Deepak Tripathi, Richard J. Wallace, Barbara A. Brown-Elliott, Torry Tucker, Steven Idell, Julie V. Philley, Ramakrishna Vankayalapati
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Nontuberculous mycobacteria (NTM) cause pulmonary disease in individuals without obvious immunodeficiency. This study was initiated to gain insight into the immunological factors that predispose persons to NTM pulmonary disease (NTMPD). Bloo
Externí odkaz:
https://doaj.org/article/d0c09b0784ff4487887debbe4abb3cea
Autor:
Ranisha Logan, Ann Jeffers, Wenyi Qin, Shuzi Owens, Prashant Chauhan, Satoshi Komatsu, Mitsuo Ikebe, Steven Idell, Torry A. Tucker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Pleural fibrosis (PF) is a chronic and progressive lung disease which affects approximately 30,000 people per year in the United States. Injury and sustained inflammation of the pleural space can result in PF, restricting lung expansion and
Externí odkaz:
https://doaj.org/article/37c5767f7ee74cd3be9d3181c0fd820a
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Respiratory viruses pose a continuing and substantive threat to human health globally. Host innate and adaptive immune responses are the critical antiviral defense mechanisms to control viral replication and spread. The present study is designed to d
Externí odkaz:
https://doaj.org/article/a06f6defd6cb462c8cfe6657ee80e098
Autor:
Galina Florova, Christian J. De Vera, Rebekah L. Emerine, René A. Girard, Ali O. Azghani, Krishna Sarva, Jincy Jacob, Danna E. Morris, Mignote Chamiso, Steven Idell, Andrey A. Komissarov
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1498 (2023)
The incidence of empyema is increasing and associated with a mortality rate of 20% in patients older than 65 years. Since 30% of patients with advanced empyema have contraindications to surgical treatment, novel, low-dose, pharmacological treatments
Externí odkaz:
https://doaj.org/article/51161308453244e58ccac30c3ac696e8
Autor:
Bock-Gie Jung, Buka Samten, Kristin Dean, Richard J Wallace, Barbara A Brown-Elliott, Torry Tucker, Steven Idell, Julie V Philley, Ramakrishna Vankayalapati
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010454 (2022)
Nontuberculous mycobacteria (NTM) infection is common in patients with structural lung damage. To address how NTM infection is established and causes lung damage, we established an NTM mouse model by intranasal inoculation of clinical isolates of M.
Externí odkaz:
https://doaj.org/article/931256ce769b45d99673d1b41efe2f81
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Empyema, a severe complication of pneumonia, trauma, and surgery is characterized by fibrinopurulent effusions and loculations that can result in lung restriction and resistance to drainage. For decades, efforts have been focused on finding a univers
Externí odkaz:
https://doaj.org/article/330799f776434f4887482578681404dc
Autor:
Sreerama Shetty, Steven Idell
Publikováno v:
Cells, Vol 12, Iss 4, p 554 (2023)
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease (ILD) for which there are no effective treatments. Lung transplantation is the only viable option for patients with end-stage PF but is only available to a minor
Externí odkaz:
https://doaj.org/article/0e184bf1b1a743e2a3e7f5386ee886f8
Autor:
Runzhen Zhao, Zhenlei Su, Andrey A. Komissarov, Shan-Lu Liu, Guohua Yi, Steven Idell, Michael A. Matthay, Hong-Long Ji
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundDynamic D-dimer level is a key biomarker for the severity and mortality of COVID-19 (coronavirus disease 2019). How aberrant fibrinolysis influences the clinical progression of COVID-19 presents a clinicopathological dilemma challenging int
Externí odkaz:
https://doaj.org/article/d1db92eab41f418699df252ca43ca716