Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Steven I. Reed"'
Publikováno v:
iScience, Vol 19, Iss , Pp 850-859 (2019)
Summary: Cyclin E, a key cell cycle regulatory protein, has been linked to oncogenesis when dysregulated. We have previously shown that overexpression of cyclin E causes replication stress, leading to failure to complete replication at specific chrom
Externí odkaz:
https://doaj.org/article/6e8f6d3efd8f417cad9ea0b6ef10c8f6
Autor:
Charles Spruck, Olle Sangfelt, Martin Widschwendter, Steven I. Reed, Dan Grander, Hans Nordgren, Per Sangfelt, Fredrik Petersson, Susanne Egyhazi, Johan Hansson, Mohammad Reza Zali, Babak Noori Nayer, Sepideh Zabihi Nejad, Markus Dagnell, Martin Corcoran, Elisabeth Mueller-Holzner, Christian Marth, Dimitra Dofou, Heidi Fiegl, Diana Cepeda, Alena Maljukova, Kathleen Klotz, Sophia Apostolidou, Natalie von der Lehr, Dahui Sun, Shahab Akhoondi
The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family of proteins, which are substrate recognition components of the multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f23907af830a4be9a61f44daaab6df85
https://doi.org/10.1158/0008-5472.c.6496770
https://doi.org/10.1158/0008-5472.c.6496770
Autor:
Charles Spruck, Olle Sangfelt, Martin Widschwendter, Steven I. Reed, Dan Grander, Hans Nordgren, Per Sangfelt, Fredrik Petersson, Susanne Egyhazi, Johan Hansson, Mohammad Reza Zali, Babak Noori Nayer, Sepideh Zabihi Nejad, Markus Dagnell, Martin Corcoran, Elisabeth Mueller-Holzner, Christian Marth, Dimitra Dofou, Heidi Fiegl, Diana Cepeda, Alena Maljukova, Kathleen Klotz, Sophia Apostolidou, Natalie von der Lehr, Dahui Sun, Shahab Akhoondi
Supplementary Table 1 from FBXW7/hCDC4 Is a General Tumor Suppressor in Human Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393ecf68db5a7048c1c006ed29fe6c1b
https://doi.org/10.1158/0008-5472.22371378.v1
https://doi.org/10.1158/0008-5472.22371378.v1
Publikováno v:
iScience, Vol 19, Iss, Pp 850-859 (2019)
iScience
iScience
Summary Cyclin E, a key cell cycle regulatory protein, has been linked to oncogenesis when dysregulated. We have previously shown that overexpression of cyclin E causes replication stress, leading to failure to complete replication at specific chromo
Autor:
David Stouffer, Jeanne F. Loring, Susanna Ekholm-Reed, Martha Henze, Dieter A. Wolf, Robert W. Baker, Alexandre Rosa Campos, Elizabeth A. Thomas, Steven I. Reed
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-7 (2019)
Communications Biology
Communications Biology
Mutations in the PARK2 gene are associated with early onset Parkinsonism. The Park2−/− mouse, however, does not exhibit neurodegeneration or other Parkinson’s disease (PD) phenotypes. Previously, we discovered that translation of Mcl-1, a pro-s
Publikováno v:
Oncotarget
The cyclin-dependent kinase-interacting proteins Cyclin-dependent Kinase Subunit 1 and 2 (CKS1 and 2) are frequently overexpressed in cancer and linked to increased aggressiveness and poor prognoses. We previously showed that CKS protein overexpressi
Autor:
John R. Yates, Julian L. Klosowiak, Steven I. Reed, Tony Hunter, Michael E. French, Aaron Aslanian
Publikováno v:
Journal of Biological Chemistry. 292:10398-10413
Homologous to E6AP C-terminal (HECT) ubiquitin (Ub) ligases (E3s) are a large class of enzymes that bind to their substrates and catalyze ubiquitination through the formation of a Ub thioester intermediate. The mechanisms by which these E3s assemble
Autor:
Miguel A. Japón, Steven I. Reed, M. Cristina Limón-Mortés, María Galindo-Moreno, María Tortolero, Servando Giráldez, Alejandro Belmonte-Fernández, Carmen Sáez, Francisco Romero
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
FASEB J
instname
FASEB J
Eukaryotic cells have developed sophisticated mechanisms to ensure the integrity of the genome and prevent the transmission of altered genetic information to daughter cells. If this control system fails, accumulation of mutations would increase risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c277fe83012dfefc02b8ac150bf2a93
Wiley Online Library
Wiley Online Library
Autor:
Leonardo K, Teixeira, Steven I, Reed
Publikováno v:
Advances in experimental medicine and biology. 1042
Precise replication of genetic material and its equal distribution to daughter cells are essential to maintain genome stability. In eukaryotes, chromosome replication and segregation are temporally uncoupled, occurring in distinct intervals of the ce
Autor:
Robert Zamudio, Yaoyang Zhang, John R. Yates, Ruiling Mu, Steven I. Reed, John Tat, William G. Dunphy, Akiko Kumagai
CKS proteins are small (9-kDa) polypeptides that bind to a subset of the cyclin-dependent kinases. The two paralogs expressed in mammals, Cks1 and Cks2, share an overlapping function that is essential for early development. However, both proteins are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9737ef5748b309ab990c9473bf1fa0c8
https://europepmc.org/articles/PMC5615187/
https://europepmc.org/articles/PMC5615187/