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Tolerability and Pharmacokinetics of SYN-004, an Orally Administered β-Lactamase for the Prevention of Clostridium difficile-Associated Disease and Antibiotic-Associated Diarrhea, in Two Phase 1 Studies

Autor: J. Andrew Bristol, Heidi Whalen, John F. Kokai-Kun, Joseph Sliman, Kenneth C. Lasseter, Olivia Coughlin, Tracey Roberts, Steven Hubert, Barbara Valero Lopez, James Longstreth

Publikováno v: Clinical Drug Investigation. 36:725-734

SYN-004 is an orally administered β-lactamase enzyme, designed to be given concurrently with certain intravenous β-lactam antibiotics like cephalosporins. SYN-004 is intended to degrade residual antibiotics excreted into the intestine as a result o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1f60974d01086422b6d69cce43c547
https://doi.org/10.1007/s40261-016-0420-0

Development of a Modified-Release Formulation of Lovastatin Targeted to Intestinal Methanogens Implicated in Irritable Bowel Syndrome With Constipation

Autor: Steven Hubert, Alan Chadwick, Andrew Bristol, Olivia Coughlin, Vince Wacher, John F. Kokai-Kun

Publikováno v: Journal of pharmaceutical sciences. 107(2)

There is growing evidence that methane production, predominantly by Methanobrevibacter smithii , in the intestines is a cause of constipation, pain, and bloating in irritable bowel syndrome with constipation (IBS-C). M smithii resides primarily in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41706283ae237c0fcbbac3f0bca67b2f
https://pubmed.ncbi.nlm.nih.gov/28989013

CG-SENSE revisited: Results from the first ISMRM reproducibility challenge.

Autor: Maier O; Institute of Medical Engineering, Graz University of Technology, Graz, Austria., Baete SH; Center for Biomedical Imaging, New York University School of Medicine, New York, NY, USA., Fyrdahl A; Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institutet, Stockholm, Sweden., Hammernik K; Department of Computing, Imperial College London, London, UK.; Institute of Computer Graphics and Vision, Graz University of Technology, Graz, Austria., Harrevelt S; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands., Kasper L; Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland.; Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.; Techna Institute, University Health Network, Toronto, ON, Canada., Karakuzu A; NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montréal, Montréal, QC, Canada., Loecher M; Department of Radiology, Stanford University, Stanford, CA, USA., Patzig F; Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland., Tian Y; Utah Center for Advanced Imaging Research (UCAIR), Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA.; Ming Hsieh Department of Electrical and Computer Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA., Wang K; Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, USA., Gallichan D; Cardiff University Brain Research Imaging Centre, Cardiff, UK., Uecker M; Institute for Diagnostic and Interventional Radiology, University Medical Center Göttingen, Göttingen, Germany.; German Centre for Cardiovascular Research (DZHK), Berlin, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany.; Campus Institute Data Science (CIDAS), University of Göttingen, Göttingen, Germany., Knoll F; Center for Biomedical Imaging, New York University School of Medicine, New York, NY, USA.

Publikováno v: Magnetic resonance in medicine [Magn Reson Med] 2021 Apr; Vol. 85 (4), pp. 1821-1839. Date of Electronic Publication: 2020 Nov 12.