Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Steven Horner"'
Autor:
Adrian Tersteegen, Stephanie H. Hoyt, Steven A. Carr, Donald Raymond, Christopher T. Lemke, Federica Piccioni, James Mullahoo, Martin Lange, Xiaoping Yang, Bethany Kaplan, Colin W. Garvie, Andrew Baker, Marcus Toetzl, Heidi Greulich, Malvina Papanastasiou, Steven Horner, Luc de Waal, Timothy A. Lewis, James R. Fuller, Sooncheol Lee, Lindsay Westlake, Andrew D. Cherniack, Joseph McGaunn, Terry Zhang, Gavin R. Schnitzler, Matthew Meyerson, Matthew J. Ranaghan, Xiaoyun Wu
Publikováno v:
'Nature Communications ', vol: 12, pages: 4375-1-4375-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
DNMDP and related compounds, or velcrins, induce complex formation between the phosphodiesterase PDE3A and the SLFN12 protein, leading to a cytotoxic response in cancer cells that express elevated levels of both proteins. The mechanisms by which velc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfd121cbb4144ac667f5c20f822fddc
https://doi.org/10.1038/s41467-021-24495-w
https://doi.org/10.1038/s41467-021-24495-w
Autor:
Justin Gilardi, Justin Leach, Sarah Leach, Jordan Hurlbut, Steven Horner, Jeffrey Chamberlain, Jermaine Jenkins, Mary Pulvino, Stephen Dewhurst, Clara Kielkopf
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 78:a34-a34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae2fa188a366b3402e94fb38d3a28c4b
https://doi.org/10.1107/s205327332209965x
https://doi.org/10.1107/s205327332209965x
Autor:
Luc de Waal, Matthew Meyerson, Bethany Kaplan, Colin W. Garvie, Martin Lange, Timothy A. Lewis, Sooncheol Lee, Heidi Greulich, Andrew Baker, Steven Horner, Chris Lemke, Xiaoyun Wu, Joseph McGaunn, Marcus Toetzl
Publikováno v:
Cancer Research. 81:54-54
We have identified a novel mechanism of selective cancer cell-killing, whereby small molecules such as DNMDP induce complex formation between phosphodiesterase 3A (PDE3A) and a poorly characterized protein, SLFN12, that leads to downstream cell death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3580c65a19afd6a3731f497776fe9792
https://doi.org/10.1158/1538-7445.am2021-54
https://doi.org/10.1158/1538-7445.am2021-54
Autor:
Heidi Gullett, Maria Cintron, Una Stenberg, Ann Reichsman, Kurt C. Stange, Ruchir N. Karmali, Steven Horner, Jelena Mirkovic, Sarah A. Sweeney, Olöf Birna Kristjansdottir, Cornelia M. Ruland, Jules Gilliam, Heide Aungst, Debra Schaadt, Richard F. Weinberger, Joy Yokie, Nicholas Cohen, Natalie Ponyicky, Jewel Williams, Anna van der Meulen, James Misak, Shirley M. Moore, Christina Bouyer, Mary C. Ruhe, Monica Baker, Kristen Hassmiller‐Lich, Rachel Martukovich, Patricia Gannon, Bruce Catalano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc87d8ffa2c1ef3fe415f2ce1e426066
https://doi.org/10.25302/3.2019.cer.732
https://doi.org/10.25302/3.2019.cer.732
Creative Aging Collaborations: New Directions in Solving Critical Societal Aging and Health Problems
Publikováno v:
Innovation in Aging
From the grassroots development of creative aging research to broad base community collaborations that address the issues of today and tomorrow, this presentation will illustrate how state departments of aging and state arts agencies can combine to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331ec3eff7ea490b1f56b4917e0aef31
https://doi.org/10.1093/geroni/igaa057.2211
https://doi.org/10.1093/geroni/igaa057.2211
Autor:
Brian J. McMillan, Chris C. A. Spencer, Pradeep Natarajan, Ayellet V. Segrè, François Aguet, Amit Khera, Connor A. Emdin, Mark Chaffin, Sekar Kathiresan, Derek Klarin, Alison Leed, Michael E. Weale, Qiuyu M Zhu, Virendar K. Kaushik, Steven Horner, Kristin G. Ardlie
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Vascular inflammation drives the initiation and progression of coronary artery disease (CAD). However, the underlying genetic factors are not well understood. We performed a genome-wide association study in UK Biobank testing 9 million DNA variants f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::381c96c37d705b8d8fcf0993fb26b614
https://doi.org/10.1161/atvb.38.suppl_1.021
https://doi.org/10.1161/atvb.38.suppl_1.021
Autor:
Steven Horner, Sekar Kathiresan, Chris C. A. Spencer, Virendar K. Kaushik, Pradeep Natarajan, Kristin G. Ardlie, Amit Khera, Connor A. Emdin, Michael E. Weale, François Aguet, Mark Chaffin, Ayellet V. Segrè, Derek Klarin, Alison Leed, Qiuyu Martin Zhu, Brian J. McMillan
Publikováno v:
Nature genetics
UK Biobank is among the world's largest repositories for phenotypic and genotypic information in individuals of European ancestry. We performed a genome-wide association study in UK Biobank testing ∼9 million DNA sequence variants for association w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0800a8a79f21c51d3090e04e191f133
https://pubmed.ncbi.nlm.nih.gov/28714974
https://pubmed.ncbi.nlm.nih.gov/28714974