Glycoprotein N-linked glycans play a critical role in arenavirus pathogenicity.

Autor: Takaaki Koma, Cheng Huang, Adrian Coscia, Steven Hallam, John T Manning, Junki Maruyama, Aida G Walker, Milagros Miller, Jeanon N Smith, Michael Patterson, Jonathan Abraham, Slobodan Paessler

Publikováno v: PLoS Pathogens, Vol 17, Iss 3, p e1009356 (2021)

Several arenaviruses cause hemorrhagic fevers in humans with high case fatality rates. A vaccine named Candid#1 is available only against Junin virus (JUNV) in Argentina. Specific N-linked glycans on the arenavirus surface glycoprotein (GP) mask impo

Externí odkaz: https://doaj.org/article/61eb758c0e974ffaae50ec79a28710df

Thousands of small, novel genes predicted in global phage genomes

Autor: Brayon J. Fremin, Ami S. Bhatt, Nikos C. Kyrpides, Aditi Sengupta, Alexander Sczyrba, Aline Maria da Silva, Alison Buchan, Amelie Gaudin, Andreas Brune, Ann M. Hirsch, Anthony Neumann, Ashley Shade, Axel Visel, Barbara Campbell, Brett Baker, Brian P. Hedlund, Byron C. Crump, Cameron Currie, Charlene Kelly, Chris Craft, Christina Hazard, Christopher Francis, Christopher W. Schadt, Colin Averill, Courtney Mobilian, Dan Buckley, Dana Hunt, Daniel Noguera, David Beck, David L. Valentine, David Walsh, Dawn Sumner, Despoina Lymperopoulou, Devaki Bhaya, Donald A. Bryant, Elise Morrison, Eoin Brodie, Erica Young, Erik Lilleskov, Eva Högfors-Rönnholm, Feng Chen, Frank Stewart, Graeme W. Nicol, Hanno Teeling, Harry R. Beller, Hebe Dionisi, Hui-Ling Liao, J. Michael Beman, James Stegen, James Tiedje, Janet Jansson, Jean VanderGheynst, Jeanette Norton, Jeff Dangl, Jeffrey Blanchard, Jennifer Bowen, Jennifer Macalady, Jennifer Pett-Ridge, Jeremy Rich, Jérôme P. Payet, John D. Gladden, Jonathan D. Raff, Jonathan L. Klassen, Jonathan Tarn, Josh Neufeld, Kelly Gravuer, Kirsten Hofmockel, Ko-Hsuan Chen, Konstantinos Konstantinidis, Kristen M. DeAngelis, Laila P. Partida-Martinez, Laura Meredith, Ludmila Chistoserdova, Mary Ann Moran, Matthew Scarborough, Matthew Schrenk, Matthew Sullivan, Maude David, Michelle A. O'Malley, Monica Medina, Mussie Habteselassie, Nicholas D. Ward, Nicole Pietrasiak, Olivia U. Mason, Patrick O. Sorensen, Paulina Estrada de los Santos, Petr Baldrian, R. Michael McKay, Rachel Simister, Ramunas Stepanauskas, Rebecca Neumann, Rex Malmstrom, Ricardo Cavicchioli, Robert Kelly, Roland Hatzenpichler, Roman Stocker, Rose Ann Cattolico, Ryan Ziels, Rytas Vilgalys, Sara Blumer-Schuette, Sean Crowe, Simon Roux, Steven Hallam, Steven Lindow, Susan H. Brawley, Susannah Tringe, Tanja Woyke, Thea Whitman, Thomas Bianchi, Thomas Mock, Timothy Donohue, Timothy Y. James, Udaya C. Kalluri, Ulas Karaoz, Vincent Denef, Wen-Tso Liu, William Whitman, Yang Ouyang

Publikováno v: Cell Rep

Small genes (40,000 small-gene families in ~2.3 million phage genome contigs. We find that small genes in phage genomes are approximately 3-fold more prevalent than in host prokaryotic genomes. Our approach enriches for small genes that are translate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7811364742ad68dd9e3a080fb28629f4
https://doi.org/10.1016/j.celrep.2022.110984

Ecology of inorganic sulfur auxiliary metabolism in widespread bacteriophages

Autor: Kristopher Kieft, Zhichao Zhou, Rika Anderson, Alison Buchan, Barbara Campbell, Steven Hallam, Matthias Hess, Matthew Sullivan, David Walsh, Simon Roux, Karthik Anantharaman

Microbial sulfur metabolism contributes to biogeochemical cycling on global scales. Sulfur metabolizing microbes are infected by phages that can encode auxiliary metabolic genes (AMGs) to alter sulfur metabolism within host cells but remain poorly ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6758107c52a9f8ccab348fd7f70f08a
https://doi.org/10.21203/rs.3.rs-68034/v1

Zika virus infection elicits auto-antibodies to C1q

Autor: Cheng Huang, Steven Hallam, Takaaki Koma, Danielle E. Anderson, Veljko Veljkovic, Slobodan Paessler, Jeanon N. Smith, David W.C. Beasley, Lin-Fa Wang, Veronika von Messling, Natalya Bukreyeva, Shannan L. Rossi, Chao Shan, Pei Yong Shi

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Scientific Reports

Zika virus (ZIKV) causes mostly asymptomatic infection or mild febrile illness. However, with an increasing number of patients, various clinical features such as microcephaly, Guillain-Barré syndrome and thrombocytopenia have also been reported. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a253b8972cdd997fcfcd5b32cad1bd1
http://link.springer.com/article/10.1038/s41598-018-20185-8

Review of Mammarenavirus Biology and Replication

Autor: Takaaki Koma, Slobodan Paessler, Steven Hallam, Junki Maruyama

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)
Frontiers in Microbiology

The family Arenaviridae is divided into three genera: Mammarenavirus, Reptarenavirus, and Hartmanivirus. The Mammarenaviruses contain viruses responsible for causing human hemorrhagic fever diseases including New World viruses Junin, Machupo, Guanari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6198e553c25001f46ac9435186ae624
https://www.frontiersin.org/article/10.3389/fmicb.2018.01751/full