Výsledky vyhledávání - "Steven H. van Leeuwen"

Determination of the Upper Size Limit for Uptake and Processing of Ligands by the Asialoglycoprotein Receptor on Hepatocytesin Vitro and in Vivo

Autor: Erik A.L. Biessen, Sabine M.W. van Rossenberg, Erwin Kieviet, Leo A. J. M. Sliedregt, Theo J.C. Van Berkel, Patrick C.N. Rensen, Steven H. van Leeuwen, Michiel Ferns

Publikováno v: Journal of Biological Chemistry. 276:37577-37584

The asialoglycoprotein receptor (ASGPr) on hepatocytes plays a role in the clearance of desialylated proteins from the serum. Although its sugar preference (N-acetylgalactosamine (GalNAc) >> galactose) and the effects of ligand valency (tetraantennar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22753ecf56e18132c6f541e6babd1a7
https://doi.org/10.1074/jbc.m101786200

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Stimulation of liver-directed cholesterol flux in mice by novel N-acetylgalactosamine-terminated glycolipids with high affinity for the asialoglycoprotein receptor

Autor: Erik A.L. Biessen, John H.M. Souverijn, Theo J.C. Van Berkel, Leo A. J. M. Sliedregt, Peter J. van Santbrink, Patrick C.N. Rensen, Michiel Ferns, Steven H. van Leeuwen, Hendrik N.J. Schifferstein

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 26(1)

Objective— Interventions that promote liver-directed cholesterol flux can suppress atherosclerosis, as demonstrated for scavenger receptor-BI overexpression in hypercholesterolemic mice. In analogy, we speculate that increasing lipoprotein flux to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a598a3d29bca7b0be6553952e535b6
https://pubmed.ncbi.nlm.nih.gov/16254203

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Design and synthesis of novel N-acetylgalactosamine-terminated glycolipids for targeting of lipoproteins to the hepatic asialoglycoprotein receptor

Autor: Theo J.C. Van Berkel, Patrick C.N. Rensen, Steven H. van Leeuwen, Erik A.L. Biessen, Leo A. J. M. Sliedregt

Publikováno v: Journal of medicinal chemistry. 47(23)

A novel glycolipid has been prepared that contains a cluster glycoside with an unusually high affinity for the asialoglycoprotein receptor (ASGPr) and a bile acid moiety that mediates stable incorporation into lipidic particles. The glycolipid sponta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75690b58d735b7f6b49564402bc941cc
https://pubmed.ncbi.nlm.nih.gov/15509179

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Rational optimization of a short human P-selectin-binding peptide leads to nanomolar affinity antagonists

Autor: Arnaud Bonnefoy, Chantal C. M. Appeldoorn, Petra Vandervoort, Tom J.M. Molenaar, Theo J.C. Van Berkel, Steven H. van Leeuwen, Marc Hoylaerts, Erik A.L. Biessen

Publikováno v: Journal of Biological Chemistry, 278(12), 10201-10207

P-selectin plays an important role in the development of various diseases, including atherosclerosis and thrombosis. In our laboratory we recently identified a number of specific human P-selectin-binding peptides containing a Glu-Trp-Val-Asp-Val cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9b3991c66bb816c2d8756b6d38dd3b
http://hdl.handle.net/1887/50002

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