Výsledky vyhledávání - "Steven H. Nye"

Autor: Michael Bittner, Pamela A. Hershberger, James G. Yarger, Wei Xu, Steven H. Nye, Erin K. Shanle, Robert E. Babine

Publikováno v: Journal of Molecular Endocrinology

Ligand structure can affect the activation of nuclear receptors, such as estrogen receptors (ERs), and their control of signaling pathways for cellular responses including death and differentiation. We hypothesized that distinct biological functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac4d14b30e8e2c40b50d074fffca633
http://europepmc.org/articles/PMC3535725

Zobrazit plný text záznamu

Liver transcriptomic changes associated with ritonavir-induced hyperlipidemia in sensitive and resistant strains of rats

Autor: Dale J. Kempf, Annette J. Dahly-Vernon, Yi Yang, Howard J. Jacob, Jie Lai-Zhang, Yvette A. Harrington, Kennan C. Marsh, Steven H Nye, Jeffrey F. Waring, Eric A.G. Blomme, Richard J. Roman, Darin L. Evans

Publikováno v: The Veterinary Journal. 185:75-82

Ritonavir (RTV) and other protease inhibitors (PIs) used for the treatment of human immunodeficiency virus (HIV) infection are associated with elevated serum triglycerides (TG) and cholesterol in some patients. A rat strain (Sprague–Dawley or SD) c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb161752767a608b06b207ed4161cc09
https://doi.org/10.1016/j.tvjl.2010.04.017

Zobrazit plný text záznamu

Introgression of Brown Norway Chromosome 1 onto the Fawn Hooded Hypertensive Background Rescues Long-Term Fear Memory Deficits

Autor: Steven H. Nye, Janine L. Kwapis, Timothy J. Jarome, Fred J. Helmstetter

Publikováno v: Behavior Genetics. 40:85-92

The isolation of genes influencing long-term memory is critical for an understanding of learning at the molecular level. Recently, chromosomal substitution rat strains, known as consomics, have been developed. Here we report the results of the first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464db68ebe94a232ff3ad5b033bb9b5f
https://doi.org/10.1007/s10519-009-9297-5

Zobrazit plný text záznamu

Rat survival to anthrax lethal toxin is likely controlled by a single gene

Autor: Howard J. Jacob, D. L. Evans, Steven H Nye, Richard J. Roman, J. A. O'Connor, A. L. Wittenburg

Publikováno v: The Pharmacogenomics Journal. 8:16-22

We examined whether survival of different rat strains administered anthrax lethal toxin is genetically determined. A reproducible test population of first filial generation hybrid rats was bred based on the susceptibility of progenitors to anthrax le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d20014d0be254aabc5a8a3a76a608c2
https://doi.org/10.1038/sj.tpj.6500448

Zobrazit plný text záznamu

In vitro and in vivo inhibition of complement activity by a single-chain Fv fragment recognizing human C5

Autor: Mark J. Evans, John P. Mueller, Steven H. Nye, Russell P. Rother, Stephen P. Squinto, Allen J. Norin, James A. Wilkins, Galo A Grijalva, Dennis W. Wolff, Denise M Therrien, Scott A. Rollins

Publikováno v: Molecular Immunology. 32:1183-1195

Complement activation has been implicated in the pathogenesis of several human diseases. Recently, a monoclonal antibody, (N19-8) that recognizes the human complement protein C5 has been shown to effectively block the cleavage of C5 into C5a and C5b,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8880708a39db086a0ba15f383dfe39c9
https://doi.org/10.1016/0161-5890(95)00099-2

Zobrazit plný text záznamu

Purification of immunologically active recombinant 21.5 kDa isoform of human myelin basic protein

Autor: John P. Mueller, Clara M. Pelfrey, Steven H. Nye, Jeffrey J. Burkwit, Rhonda R. Voskuhl, Michael J. Lenardo

Publikováno v: Molecular Immunology. 32:1131-1141

We have designed and expressed in bacteria a recombinant fetal form of human myelin basic protein (21.5 kDa isoform; rhMBP21.5), a candidate autoantigen in multiple sclerosis. An exon 2 insertion, carboxy-terminal histidine tag and preferred bacteria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a955b4dfac48becee8c81af04ea4e1
https://doi.org/10.1016/0161-5890(95)00066-6

Zobrazit plný text záznamu

K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses

Autor: Steven H. Nye, Trevor Stitt, Stephen P. Squinto, M J Macchi, David J. Glass, George D. Yancopoulos, N S Lindsay, Nancy Y. Ip, Petros A. Hantzopoulos

Publikováno v: Molecular Biology of the Cell. 3:677-686

The same receptor tyrosine kinase (RTK) can mediate strikingly different biological responses in a fibroblast as opposed to a neuron. We have compared the rapidly induced tyrosine phosphorylations mediated by various RTKs in both NIH3T3 fibroblasts a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21689daf22677ac624c9662e4059d877
https://doi.org/10.1091/mbc.3.6.677

Zobrazit plný text záznamu

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

Autor: Neil Stahl, Steven H. Nye, Yanping Li, Susan J. Birren, Nancy Y. Ip, Tert G. Boulton, David J. Anderson, Tadamitus Kishimoto, Tetsuya Taga, Samuel Davis, Kiyoshi Yasukawa, George D. Yancopoulos

Publikováno v: Cell. 69:1121-1132

Ciliary neurotrophic factor (CNTF) has a variety of actions within the nervous system. While some of the actions of leukemia inhibitory factor (LIF) on neurons resemble those of CNTF, LIF also has broad actions outside of the nervous system that in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303d665a3a6f1bf09f641ecce531eb0e
https://doi.org/10.1016/0092-8674(92)90634-o

Zobrazit plný text záznamu

Introgression of Brown Norway chromosome 13 improves visual spatial memory in the Dahl S rat

Autor: Lee O. Villatoro, Rodney A. Swain, Steven H. Nye, Megan L. Hensel, Abigail L. Kerr, Todd C. Peterson

Publikováno v: Behavior genetics. 40(1)

The present study was conducted in an effort to evaluate whether chromosomal substitution can repair impaired exploration learning and memory. It has previously been observed that Dahl salt-sensitive (SS) rodents exhibit impaired cognitive function a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6fe6c2db7c5ee4c30a7b1741200c70
https://pubmed.ncbi.nlm.nih.gov/19763809

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání