Zobrazeno 1 - 10 of 60 pro vyhledávání: '"Steven H Olson"'
1
Akademický článek
The E46K mutation modulates α-synuclein prion replication in transgenic mice.
Autor: Sara A M Holec, Jisoo Lee, Abby Oehler, Lyn Batia, Aryanna Wiggins-Gamble, Jeffrey Lau, Felicia K Ooi, Gregory E Merz, Man Wang, Daniel A Mordes, Steven H Olson, Amanda L Woerman
Publikováno v: PLoS Pathogens, Vol 18, Iss 12, p e1010956 (2022)
In multiple system atrophy (MSA), the α-synuclein protein misfolds into a self-templating prion conformation that spreads throughout the brain, leading to progressive neurodegeneration. While the E46K mutation in α-synuclein causes familial Parkins
Externí odkaz: https://doaj.org/article/1cc5104ca63749ee94a0198a2fd4598b
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2
Akademický článek
Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.
Autor: Amanda L Woerman, Smita Patel, Sabeen A Kazmi, Abby Oehler, Jisoo Lee, Daniel A Mordes, Steven H Olson, Stanley B Prusiner
Publikováno v: PLoS Pathogens, Vol 16, Iss 2, p e1008222 (2020)
Multiple system atrophy (MSA), a progressive neurodegenerative disease characterized by autonomic dysfunction and motor impairment, is caused by the self-templated misfolding of the protein α-synuclein. With no treatment currently available, we soug
Externí odkaz: https://doaj.org/article/aabf984527cd4b41bb2ce6dcbd7e2056
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3
Akademický článek
Biased allosteric modulator of neurotensin receptor 1 reduces ethanol drinking and responses to ethanol administration in rodents
Autor: Graydon B. Gereau, Diana Zhou, Kalynn Van Voorhies, Ryan E. Tyler, Jeffrey Campbell, Jackson G. Murray, Ali Alvarez-Pamir, Luke A. Wykoff, Michel A. Companion, Michael R. Jackson, Steven H. Olson, Lawrence S. Barak, Lauren M. Slosky, Ryan P. Vetreno, Joyce Besheer, Zoe A. McElligott
Publikováno v: Addiction Neuroscience, Vol 13, Iss , Pp 100185- (2024)
Alcohol use disorders (AUDs) impose an enormous societal and financial burden, and world-wide, alcohol misuse is the 7th leading cause of premature death [1]. Despite this, there are currently only 3 FDA approved pharmacological approaches for the tr
Externí odkaz: https://doaj.org/article/d94961354bbf425ea2efeab23e05c46e
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7
Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex
Autor: Yongmei, Feng, Stefan, Grotegut, Predrag, Jovanovic, Valentina, Gandin, Steven H, Olson, Rabi, Murad, Anne, Beall, Sharon, Colayco, Paul, De-Jesus, Sumit, Chanda, Brian P, English, Robert H, Singer, Michael, Jackson, Ivan, Topisirovic, Ze'ev A, Ronai
Publikováno v: Frontiers in Pharmacology. 13
The translation initiation complex 4F (eIF4F) is a rate-limiting factor in protein synthesis. Alterations in eIF4F activity are linked to several diseases, including cancer and infectious diseases. To this end, coronaviruses require eIF4F complex act
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d73a368f184b2eee8c306370f56bf0a
https://doi.org/10.3389/fphar.2022.1029093
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8
NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling
Autor: Sachin Verma, David Crawford, Ali Khateb, Yongmei Feng, Eduard Sergienko, Gaurav Pathria, Chen-Ting Ma, Steven H. Olson, David Scott, Rabi Murad, Eytan Ruppin, Michael Jackson, Ze’ev A. Ronai
Publikováno v: Nat Cell Biol
Tumour dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the mitochondrial protein glutaryl-CoA dehydrogenase (GCDH), which functions in lysine metabolis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d4299a68863154ef2339bde519cb8e
https://europepmc.org/articles/PMC9977532/
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9
Multiple system atrophy prions transmit neurological disease to mice expressing wild-type human α-synuclein
Autor: Sara A. M. Holec, Jisoo Lee, Abby Oehler, Felicia K. Ooi, Daniel A. Mordes, Steven H. Olson, Stanley B. Prusiner, Amanda L. Woerman
Publikováno v: Acta neuropathologica. 144(4)
In multiple system atrophy (MSA), the protein α-synuclein misfolds into a prion conformation that self-templates and causes progressive neurodegeneration. While many point mutations in the α-synuclein gene, SNCA, have been identified as the cause o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d95041af42790fa69600526623f967c
https://pubmed.ncbi.nlm.nih.gov/36018376
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10
Selectivity in the Addition of Electron‐Deficient Radicals to the C 2 Position of Indoles
Autor: Jay Conrad, Mark Munson, Roy J. Vaz, Yi Li, Steven H. Olson, Nick A. Paras
Publikováno v: European Journal of Organic Chemistry. 2020:5828-5832
The addition of electron deficient radicals to the C2 position of indoles has been described in the literature as opposed to electrophilic addition at the C3 position. Density functional theory calculations were used to understand the switch in regio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::793be05dd835a38c24b43967b1fbc434
https://doi.org/10.1002/ejoc.201901784
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