Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Steven H Hefeneider"'
Autor:
John R. Klune, Sharon L. McCoy, Timothy R. Billiar, Allan Tsung, David A. Geller, Steven H. Hefeneider
Publikováno v:
Shock. 27:364-369
Sepsis resulting from gram-negative bacterial infections is characterized by an excessive inflammatory immune response initiated by exposure of the host innate immune system to either bacteria or bacterial products, primarily lipopolysaccharide (LPS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87961269c52b8f4922d3dd0b7f91f822
https://doi.org/10.1097/01.shk.0000239773.95280.2c
https://doi.org/10.1097/01.shk.0000239773.95280.2c
Publikováno v:
The Journal of Immunology. 174:3006-3014
TLRs recognize and respond to conserved motifs termed pathogen-associated molecular patterns. TLRs are characterized by an extracellular leucine-rich repeat motif and an intracellular Toll/IL-1R domain. Triggering of TLRs by pathogen-associated molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37325226a821ba769afc66cb6061f57
https://doi.org/10.4049/jimmunol.174.5.3006
https://doi.org/10.4049/jimmunol.174.5.3006
Autor:
Robert M. Bennett, Sharon L. McCoy, Frances A. Hausman, Steven H. Hefeneider, Dennis R. Trune, Stephen E. Kurtz
Publikováno v:
Journal of Biological Chemistry. 279:17217-17223
Bacterial DNA containing unmethylated CpG motifs is a pathogen-associated molecular pattern (PAMP) that interacts with host immune cells via a toll-like receptor (TLR) to induce immune responses. DNA binding and internalization into cells is independ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7490ae7c1319a92aee0882f5deb6abf3
https://doi.org/10.1074/jbc.m303837200
https://doi.org/10.1074/jbc.m303837200
Autor:
Sharon L. McCoy, T. Dan Bracken, Arthur S. Hall, Frances A. Hausman, Steven H. Hefeneider, Nancy Perrin, Diana Takahashi, K.Y. Shin, Heidi L. Christensen
Publikováno v:
Bioelectromagnetics. 22:170-177
This study was designed to assess the effect of exposure to long-term extremely low-frequency electric and magnetic fields (ELF–EMF) from a 500 kV transmission line on IL-1 and IL-2 activity in sheep. The primary hypothesis was that the reduction i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b09a38172c85646291116fe5df0352
https://doi.org/10.1002/bem.35
https://doi.org/10.1002/bem.35
Autor:
Louise S. Merkens, Antony C. Bakke, Frances A. Hausman, Steven H. Hefeneider, Mark E. Deffebach, Robert M. Bennett, Sharon L. McCoy
Publikováno v:
Journal of Immunological Methods. 241:141-146
DNA binding to cell-surfaces has been documented in several studies. The interaction of DNA with cells has been shown to have therapeutic potential as a non-viral form of gene delivery and DNA vaccination. Recently, bacterial DNA binding and internal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20260a47380d2a3d3d51a5365cc3fcd9
https://doi.org/10.1016/s0022-1759(00)00205-2
https://doi.org/10.1016/s0022-1759(00)00205-2
Publikováno v:
Hearing Research. 137:160-166
Corticosteroid therapy is used to reverse autoimmune sensorineural hearing loss, although little is known of the mechanism by which this occurs. This has been due to the lack of a suitable animal model with spontaneous hearing loss that is steroid re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05e261142d91042fc2a097cb85ccca6
https://doi.org/10.1016/s0378-5955(99)00147-1
https://doi.org/10.1016/s0378-5955(99)00147-1
Autor:
Sharon L. McCoy, Kenneth A. Cornell, Robert M. Bennett, Steven H. Hefeneider, Antony C. Bakke, Lisa E. Brown
Publikováno v:
Autoimmunity. 15:187-194
DNA binds to cell-surface proteins on human and murine leukocytes and induces secretion of the cytokine interleukin 6 (IL-6). Cell-surface DNA binding molecules have been shown to serve as target antigens for the production of autoantibodies in patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c3552a65f0752ad80154c95c3cbe49
https://doi.org/10.3109/08916939309019926
https://doi.org/10.3109/08916939309019926
Autor:
M. J. Merritt, Antony C. Bakke, Robert M. Bennett, Kenneth A. Cornell, Steven H. Hefeneider, Dan V. Mourich
Publikováno v:
Clinical and Experimental Immunology. 90:428-433
SUMMARYAnti-idiotypic anti-DNA antibodies (anti-anti-DNA) have previously been described in both patients with systemic lupus erythematosus and healthy individuals. Jerne's hypothesis predicts that such antibodies would bear a paratope reactive with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d450ee258de25bca3d5bf867dd0c486e
https://doi.org/10.1111/j.1365-2249.1992.tb05863.x
https://doi.org/10.1111/j.1365-2249.1992.tb05863.x
Publikováno v:
The Laryngoscope. 116(7)
Objectives/Hypothesis: Chronic otitis media is a significant clinical problem. Understanding the mechanisms of chronic otitis media is critical for its control. However, little is known of these processes as a result of lack of animal models of spont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c1ace23d98068f78c9a037190accb7
https://pubmed.ncbi.nlm.nih.gov/16826039
https://pubmed.ncbi.nlm.nih.gov/16826039
Autor:
J. Beth Kempton, Sarah K. Parrish, Steven H. Hefeneider, Sharon L. McCoy, Carol J. MacArthur, Dennis R. Trune
Publikováno v:
Hearing research. 219(1-2)
Various animal models have been employed for otitis media research. The mouse has been studied less, in spite of its many advantages. To better understand the suitability of the mouse for studies of otitis media, an evaluation was made of its middle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0b6307723976fb14d4ced3d948be1a
https://pubmed.ncbi.nlm.nih.gov/16887307
https://pubmed.ncbi.nlm.nih.gov/16887307