Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Steven H Caplan"'
Autor:
Benjamin J. Nichols, Gregory C. Rogers, Steven H Caplan, Kriti Bahl, Trey Farmer, Shuwei Xie, Ivana Yeow, Naava Naslavsky, Tiffany A. McLamarrah, James B. Reinecke
Publikováno v:
Molecular Biology of the Cell
Centrosomes are the major microtubule-nucleating and microtubule-organizing centers of cells and play crucial roles in microtubule anchoring, organelle positioning, and ciliogenesis. At the centrosome core lies a tightly associated or “engaged” m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71a6d9bcf254591adaf8674fc3c11cb
https://doi.org/10.1091/mbc.e18-04-0241
https://doi.org/10.1091/mbc.e18-04-0241
Publikováno v:
Traffic. 19:569-577
The mitochondrion is a unique organelle that serves as the main site of adenosine triphosphate (ATP) generation needed for energy in the cell. However, mitochondria also play essential roles in cell death through apoptosis and necrosis, as well as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684ad009fe5839ea8c142a1eb7b117fc
https://doi.org/10.1111/tra.12573
https://doi.org/10.1111/tra.12573
Publikováno v:
Journal of Biological Chemistry. 291:13465-13478
An elaborate network of dynamic lipid membranes, termed tubular recycling endosomes (TRE), coordinates the process of endocytic recycling in mammalian cells. The C-terminal Eps15 homology domain (EHD)-containing proteins have been implicated in the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72ec455492e1871dc0d20c20a001c8e
https://doi.org/10.1074/jbc.m116.716407
https://doi.org/10.1074/jbc.m116.716407
Autor:
Steven H Caplan, Naava Naslavsky
Publikováno v:
Journal of Cell Science. 131
The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The term endosome relates to the receptacle-like nature of this organelle,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035e77302bb179d2ed376a46d7164cfa
https://doi.org/10.1242/jcs.216499
https://doi.org/10.1242/jcs.216499
Autor:
Steven H Caplan, Yeh-Long Chen, Dannah R. Miller, Cherng-Chyi Tzeng, Trey Farmer, Evan T. Keller, Yu Shuin Chen, Ming Fong Lin
Publikováno v:
Cancer letters. 436
The standard-of-care treatment for metastatic prostate cancer (PCa) is androgen deprivation therapy (ADT). Nevertheless, most tumors eventually relapse and develop into lethal castration-resistant prostate cancer (CRPC). Docetaxel is a FDA-approved a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e20928c6d4c36414584e27f8148311
https://pubmed.ncbi.nlm.nih.gov/30077739
https://pubmed.ncbi.nlm.nih.gov/30077739
Publikováno v:
Journal of Cell Science.
Mitochondria play essential roles in cellular energy processes, including ATP production, control of reactive oxygen species (ROS) and apoptosis. While mitochondrial function is regulated by the dynamics of fusion and fission, mitochondrial homeostas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0759004e9e21212597fa2418c612c49
https://doi.org/10.1242/jcs.204537
https://doi.org/10.1242/jcs.204537
Publikováno v:
Biomolecular NMR Assignments. 8:263-267
The C-terminal Eps15 homology (EH) domain 3 (EHD3) belongs to a eukaryotic family of endocytic regulatory proteins and is involved in the recycling of various receptors from the early endosome to the endocytic recycling compartment or in retrograde t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4701f815ccba610003ccd66044851493
https://doi.org/10.1007/s12104-013-9497-z
https://doi.org/10.1007/s12104-013-9497-z
Autor:
Steven H Caplan
Publikováno v:
Journal of Biological Chemistry. 292:7283-7284
The Rab family of small GTPases functions in multiple aspects of cellular membrane trafficking. Proteins bearing a differentially expressed in normal and neoplastic cells (DENN) domain have emerged as the largest family of Rab-activating guanine nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6557eb23dd14ae90fded3b66059cc5
https://doi.org/10.1074/jbc.h116.772434
https://doi.org/10.1074/jbc.h116.772434
Publikováno v:
The Journal of Neuroscience. 30:16485-16497
In neurons, the endosomal system is essential for membrane receptor trafficking to dendrites and axons and thereby participates in various neuronal functions, such as neurite outgrowth and synaptic plasticity. A multitude of regulators coordinates tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7086e43f40923ee334cc0ade7477c7
https://doi.org/10.1523/jneurosci.3127-10.2010
https://doi.org/10.1523/jneurosci.3127-10.2010
Publikováno v:
Experimental Cell Research. 316:859-874
In several invertebrate organisms, the Sec1p/Munc18-like protein Vps45 interacts with the divalent Rab4/Rab5 effector, Rabenosyn-5 and carries out multiple functions in the endocytic/secretory pathways. In mammalian cells, Vps45 and Rabenosyn-5 also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5d4279e8cbb3e374eec1ca5dd5e929
https://doi.org/10.1016/j.yexcr.2009.11.007
https://doi.org/10.1016/j.yexcr.2009.11.007