Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Steven H, Green"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Spiral ganglion neurons (SGNs) transmit auditory information from cochlear hair cells to the brain. SGNs are thus not only important for normal hearing, but also for effective functioning of cochlear implants, which stimulate SGNs when hair cells are
Externí odkaz:
https://doaj.org/article/e28d457695bc4837b934a55f7f54f2c5
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
IntroductionCochlear afferent synapses connecting inner hair cells to spiral ganglion neurons are susceptible to excitotoxic trauma on exposure to loud sound, resulting in a noise-induced cochlear synaptopathy (NICS). Here we assessed the ability of
Externí odkaz:
https://doaj.org/article/35549f85a4494e3da446090bc0fc65a0
Autor:
Muhammad T. Rahman, Erin M. Bailey, Benjamin M. Gansemer, Andrew A. Pieper, J. Robert Manak, Steven H. Green
Publikováno v:
Neurotherapeutics. 20:578-601
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db8f353e1afd1dfd6b5b223c14b314df
https://doi.org/10.1007/s13311-022-01336-2
https://doi.org/10.1007/s13311-022-01336-2
Autor:
Steven H. Green, Sepand Bafti, Benjamin M. Gansemer, A. Eliot Shearer, Muhammad Taifur Rahman, Mark E. Warchol, Marlan R. Hansen
Publikováno v:
Hair Cell Regeneration ISBN: 9783031206603
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c17099f84dc74e7cff9ee3fad970279d
https://doi.org/10.1007/978-3-031-20661-0_7
https://doi.org/10.1007/978-3-031-20661-0_7
Publikováno v:
Proceedings of the National Academy of Sciences. 117:3828-3838
Exposure to loud sound damages the postsynaptic terminals of spiral ganglion neurons (SGNs) on cochlear inner hair cells (IHCs), resulting in loss of synapses, a process termed synaptopathy. Glutamatergic neurotransmission via α-amino-3-hydroxy-5-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf728babbdbc85afd3440085825f0833
https://doi.org/10.1073/pnas.1914247117
https://doi.org/10.1073/pnas.1914247117
Autor:
Eric Bouffet, Trent R. Hummel, Anne Isabelle Bertozzi, Violet Shen, Noelia Nebot, Ira J. Dunkel, Christine A. Pratilas, Andrew D.J. Pearson, James A. Whitlock, Mark W. Kieran, Kenneth J. Cohen, Steven H. Green, Darren Hargrave, Isabelle Aerts, Pooja Hingorani, Alberto Broniscer, Birgit Geoerger, Mark W. Russo, Lillian Tseng
Publikováno v:
Clinical Cancer Research. 25:7294-7302
Purpose: The 2-part, phase I/IIa, open-label study (NCT01677741) sought to determine the safety, tolerability, pharmacokinetics, and preliminary activity of dabrafenib in pediatric patients with advanced BRAF V600–mutated cancers. Patients and Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46f736978b8c920f3dced763dc75d9f4
https://doi.org/10.1158/1078-0432.ccr-17-3572
https://doi.org/10.1158/1078-0432.ccr-17-3572
Autor:
Muhammad T. Rahman, Erin M. Bailey, Benjamin M. Gansemer, Andrew Pieper, J. Robert Manak, Steven H. Green
Spiral ganglion neurons (SGNs) relay auditory information from cochlear hair cells to the central nervous system. After hair cells are destroyed by aminoglycoside antibiotics, SGNs gradually die. However, the reasons for this cochlear neurodegenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5980d2edd758bcb250cc03001df5d003
https://doi.org/10.1101/2021.12.03.470945
https://doi.org/10.1101/2021.12.03.470945
Publikováno v:
Proc Natl Acad Sci U S A
Exposure to loud sound damages the postsynaptic terminals of spiral ganglion neurons (SGNs) on cochlear inner hair cells (IHCs), resulting in loss of synapses, a process termed synaptopathy. Glutamatergic neurotransmission via α-amino-3-hydroxy-5-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e498f951cc85068edd7be52b7693c5a
https://pubmed.ncbi.nlm.nih.gov/32015128
https://pubmed.ncbi.nlm.nih.gov/32015128
Publikováno v:
Hearing Research. 364:48-58
CaBPs are a family of Ca(2+) binding proteins related to calmodulin. Two CaBP family members, CaBP1 and CaBP2, are highly expressed in the cochlea. Here, we investigated the significance of CaBP1 and CaBP2 for hearing in mice lacking expression of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b7cedf37bf593a9e9497c45b7da8f5
https://doi.org/10.1016/j.heares.2018.04.001
https://doi.org/10.1016/j.heares.2018.04.001
Autor:
Ronald A Merrill, Ruben K Dagda, Audrey S Dickey, J Thomas Cribbs, Steven H Green, Yuriy M Usachev, Stefan Strack
Publikováno v:
PLoS Biology, Vol 9, Iss 4, p e1000612 (2011)
Mitochondrial shape is determined by fission and fusion reactions catalyzed by large GTPases of the dynamin family, mutation of which can cause neurological dysfunction. While fission-inducing protein phosphatases have been identified, the identity o
Externí odkaz:
https://doaj.org/article/9416d933b26d4774ad931fda500fafb0