Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Steven Gygi"'
Publikováno v:
Bio-Protocol, Vol 12, Iss 3 (2022)
Cells sense and respond to mitogens by activating a cascade of signaling events, primarily mediated by tyrosine phosphorylation (pY). Because of its key roles in cellular homeostasis, deregulation of this signaling is often linked to oncogenesis. To
Externí odkaz:
https://doaj.org/article/d5bbbef2e9b446dcba9c3bf6893a3086
Autor:
Jonas Dutra Albarnaz, Marisa Oliveira, Joanne Kite, Joao Paulo, Robin Antrobus, Steven Gygi, Edward Huttlin, Geoffrey Smith, Michael Weekes
Modified vaccinia Ankara (MVA) immunisation is being deployed to curb the current outbreak of monkeypox in multiple countries1. Originally authorized for vaccination against smallpox, MVA is a vaccinia virus (VACV) strain that does not replicate in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b99cd52604ad6b9e3d835c402e3ec692
https://doi.org/10.21203/rs.3.rs-1850393/v1
https://doi.org/10.21203/rs.3.rs-1850393/v1
Autor:
Jaime Laurel Schneider, Kiran Kurmi, Ishita Dhiman, Roberta Colapietro, Shakchhi Joshi, Christian Johnson, Satoshi Yoda, Joao Paulo, Daniela Ruiz, Sylwia Stopka, Gerard Baquer, Jessica Lin, Kevin Haigis, Nathalie Agar, Steven Gygi, Aaron Hata, Marcia Haigis
Publikováno v:
Cancer Research. 83:1156-1156
There is a longstanding desire to take therapeutic advantage of dysregulated metabolic states in cancer. While it has been appreciated that lung tumors rewire their cellular metabolic networks to support unrestrained proliferation, metabolic vulnerab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::374e66b9c88cb6e1d2fd2ab32c1f4fcf
https://doi.org/10.1158/1538-7445.am2023-1156
https://doi.org/10.1158/1538-7445.am2023-1156
Autor:
Silvia Alvarez, Ana C. da Silva Almeida, Robert Albero, Mayukh Biswas, Angelica Barreto-Galvez, Thomas S. Gunning, Anam Shaikh, Tomas Aparicio, Agnieszka Wendorff, Erich Piovan, Pieter Van Vlierberghe, Steven Gygi, Jean Gautier, Advaitha Madireddy, Adolfo A. Ferrando
Publikováno v:
BLOOD
The Plant Homeodomain 6 gene (PHF6) encodes a nucleolar and chromatin-associated leukemia tumor suppressor with proposed roles in transcription regulation. However, specific molecular mechanisms controlled by PHF6 remain rudimentarily understood. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b8b51d72bff8ab2f97c067a8326c07
https://pubmed.ncbi.nlm.nih.gov/35679076
https://pubmed.ncbi.nlm.nih.gov/35679076
Autor:
Inga-Marie Schaefer, Meijun Z. Lundberg, Matthew L. Hemming, Sinem K. Saka, Matthew P. Serrata, Isabel Goldaracena, Ninning Liu, Peng Yin, Joao A. Paulo, Steven Gygi, George D. Demetri, Ewa Sicinska, Adrian Mariño-Enríquez, Jason L. Hornick, Chandrajit P. Raut, Wen-Bin Ou, Jonathan A. Fletcher
Publikováno v:
Cancer Research. 82:5648-5648
Gastrointestinal stromal tumor (GIST) is the most common GI sarcoma and is generally initiated by KIT or PDGFRA mutations which are compelling therapeutic targets for tyrosine kinase inhibitors (TKI). However, the emergence of secondary mutations res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7578e742f8444f94b6cccf6aeb739722
https://doi.org/10.1158/1538-7445.am2022-5648
https://doi.org/10.1158/1538-7445.am2022-5648
Autor:
Benjamin Cravatt, Yujia Wang, melissa dix, jarrett remsberg, hsin-yu lee, marian kalocsay, steven gygi, gregory vite, michael lawrence, Christopher Parker
A fundamental challenge in chemical biology and medicine is to understand and expand the fraction of the human proteome that can be targeted by small molecules. We recently described a strategy that integrates fragment-based ligand discovery with che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad065a927a8cd902fcd9c51fe95c014e
https://doi.org/10.26434/chemrxiv.7764638
https://doi.org/10.26434/chemrxiv.7764638