Genomics of protein folding in the endoplasmic reticulum, secretion stress and glycosylation in the aspergilli

Autor: Graham Whyteside, David B. Archer, Steven Geysens

Publikováno v: Fungal Genetics and Biology. 46:S121-S140

We review aspects of the process of protein secretion by Aspergillus niger and Aspergillus nidulans , based on analysis of their genome sequences. Where useful, we have taken a comparative approach with the yeasts Saccharomyces cerevisiae and Pichia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd63a3dd3ee98e01ad04cb9c3d0f23fa
https://doi.org/10.1016/j.fgb.2008.07.016

Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88

Autor: Marc J. E. C. van der Maarel, Marco A. van den Berg, Steven Geysens, Etienne Danchin, Rachel M. van der Kaaij, Hein Stam, Jibin Sun, Kaj Albermann, Maurien M.A. Olsthoorn, Arnold J. M. Driessen, Frans M. Klis, Monika Schmoll, Gerald Hofmann, K. Pal, Thomas Guillemette, Bernard Henrissat, Johannes H. de Winde, David B. Archer, Coenie Goosen, Pedro M. Coutinho, Richard Albang, Michael Cornell, Jens Nielsen, Johannes Andries Roubos, Harrie J. Kools, Peter J.J. Van De Vondervoort, Cornelis Maria Jacobus Sagt, Noël Nicolaas Maria Elisabeth Van Peij, Jannick Dyrløv Bendtsen, Alard Van Dijk, Marga Herweijer, Martin Mortimer, Ursula Rinas, An-Ping Zeng, Roland Contreras, Holger Wedler, Stephen G. Oliver, Cees A. M. J. J. van den Hondel, David W. Ussery, Gert S.P. Groot, Jaap Visser, Mikael Rørdam Andersen, Arthur F. J. Ram, Hildegard Henna Menke, René T. J. M. van der Heijden, Paul S. Dyer, Piet W. J. de Groot, Han A. B. Wösten, Alfons J. M. Debets, Jacques A.E. Benen, János Varga, Lubbert Dijkhuizen, Christian P. Kubicek, Peter J. T. Dekker, Albert J. J. van Ooyen, Johannes Petrus Theodorus Wilhelmus Van Den Hombergh, Ronald P. de Vries, Rogier Meulenberg, Jürgen Lauber, Mark X. Caddick, Geoffrey Turner, Xin Lu, Patricia Ann van Kuyk, Wouter Vervecken, Peter J. Schaap, Piet W.M. van Dijck, Stefaan Breestraat, Herman Jan Pel, Christophe d'Enfert

Publikováno v: Nature Biotechnology, 25(2), 221-231
Nature Biotechnology
Nature Biotechnology, Nature Publishing Group, 2007, 25 (2), pp.221-231. ⟨10.1038/nbt1282⟩
Nature Biotechnology, 25(2), 221-231. Nature Publishing Group
Nature Biotechnology, 2007, 25 (2), pp.221-231. ⟨10.1038/nbt1282⟩
Nature Biotechnology 25 (2007)
Nature Biotechnology, 25, 221-31
Nature Biotechnology, 25, 2, pp. 221-31
Nature Biotechnology, 25, 221-231
Nature Biotechnology, 25(2), 221. Nature Publishing Group
Technical University of Denmark Orbit

Contains fulltext : 51722.pdf (Publisher’s version ) (Closed access) The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3d8832d6c3443d190409999a1cdf16
https://doi.org/10.1038/nbt1282

Factors influencing glycosylation of Trichoderma reesei cellulases. I: Postsecretorial changes of the O- and N-glycosylation pattern of Cel7A

Autor: Marc Claeyssens, Koen Sandra, Roland Contreras, Ingeborg Stals, Steven Geysens, Jozef Van Beeumen

Publikováno v: Glycobiology. 14:713-724

The glycosylation of Cel7A (CBH I) from Trichoderma reeseivaries considerably when the fungus is grown under differentconditions. As shown by ESI-MS and PAG-IEF analyses ofboth intact protein and the isolated catalytic core module, themicroheterogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba3a5771be87919f5a8ca6e9108b485
https://doi.org/10.1093/glycob/cwh080

A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes

Autor: Franck Fudalej, Jan Robert Ludo Stout, Paco Hulpiau, Han Remaut, Annelies Van Hecke, Simon Tännler, Kathleen Piens, Petra Tiels, Ekatarina Baranova, Wim Nerinckx, Nico Callewaert, Albena Vergilieva Valevska, Steven Geysens, Gwenda Noella Pynaert, Charlotte De Visscher, Wouter Vervecken

Publikováno v: Vrije Universiteit Brussel

Lysosomal storage diseases are treated with human lysosomal enzymes produced in mammalian cells. Such enzyme therapeutics contain relatively low levels of mannose-6-phosphate, which is required to target them to the lysosomes of patient cells. Here w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a75a9849f164cd433e7868061e77b26
https://biblio.vub.ac.be/vubir/a-bacterial-glycosidase-enables-mannose6phosphate-modification-and-improved-cellular-uptake-of-yeastproduced-recombinant-human-lysosomal-enzymes(8692e185-c6f1-41c3-ae58-b7e3ac80e98c).html

Pichia surface display: display of proteins on the surface of glycoengineered Pichia pastoris strains

Autor: Roland Contreras, Steven Geysens, Pieter P. Jacobs, Stefan Ryckaert, Kristof De Vusser, Nico Callewaert

Publikováno v: Biotechnology letters. 30(12)

Expression of proteins on the surface of yeasts has a wide range of applications in biotechnology, such as directed evolution of proteins for increased affinity and thermal stability, screening of antibody libraries, epitope mapping, and use as whole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defe579428868e48742bfe46a849f0e7
https://pubmed.ncbi.nlm.nih.gov/18679585