Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Steven G. Widen"'
Autor:
Ted G. Graber, Rosario Maroto, Jill K. Thompson, Steven G. Widen, Zhaohui Man, Megan L. Pajski, Blake B. Rasmussen
Publikováno v:
Journal of Ageing and Longevity, Vol 3, Iss 2, Pp 159-178 (2023)
One inevitable consequence of aging is the gradual deterioration of physical function and exercise capacity, driven in part by the adverse effect of age on muscle tissue. We hypothesized that relationships exist between age-related differentially exp
Externí odkaz:
https://doaj.org/article/1b08a17837f44e75b8e7572f5c2f07ce
Autor:
Hongjie Xia, Jason Yeung, Birte Kalveram, Cody J. Bills, John Yun-Chung Chen, Chaitanya Kurhade, Jing Zou, Steven G. Widen, Brian R. Mann, Rebecca Kondor, C. Todd Davis, Bin Zhou, David E. Wentworth, Xuping Xie, Pei-Yong Shi
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 1 (2023)
ABSTRACTThe rapid evolution of SARS-CoV-2 Omicron sublineages mandates a better understanding of viral replication and cross-neutralization among these sublineages. Here we used K18-hACE2 mice and primary human airway cultures to examine the viral fi
Externí odkaz:
https://doaj.org/article/47204c3dfe2f402294bba8cbafe7c13a
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Severe burn results in muscle wasting affecting quality of life in both children and adults. Biologic metabolic profiles are noticeably distinctive in childhood. We posit that muscle gene expression profiles are differentially regulated in r
Externí odkaz:
https://doaj.org/article/ae7ee0d5e0a345e6b76720388bd91dbe
Autor:
Philipp A. Ilinykh, Sivakumar Periasamy, Kai Huang, Natalia A. Kuzmina, Palaniappan Ramanathan, Michelle N. Meyer, Chad E. Mire, Ivan V. Kuzmin, Preeti Bharaj, Jessica R. Endsley, Maria Chikina, Stuart C. Sealfon, Steven G. Widen, Mark A. Endsley, Alexander Bukreyev
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-16 (2022)
Abstract Respiratory tract vaccination has an advantage of needle-free delivery and induction of mucosal immune response in the portal of SARS-CoV-2 entry. We utilized human parainfluenza virus type 3 vector to generate constructs expressing the full
Externí odkaz:
https://doaj.org/article/f7f896e4aff94be8a7c13063d10aa8bd
Autor:
Javier I. Sanchez-Villamil, Daniel Tapia, Nittaya Khakhum, Steven G. Widen, Alfredo G. Torres
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Melioidosis is a disease caused by the Gram-negative bacillus Burkholderia pseudomallei (Bpm), commonly found in soil and water of endemic areas. Naturally acquired human melioidosis infections can result from either exposure through percutaneous ino
Externí odkaz:
https://doaj.org/article/dddcfd285488452187310ce488357872
Autor:
Emily H. Davis, Andrew S. Beck, Li Li, Mellodee M. White, Marianne Banks Greenberg, Jill K. Thompson, Steven G. Widen, Alan D. T. Barrett, Nigel Bourne
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract Japanese encephalitis virus (JEV) is the etiological agent of Japanese encephalitis (JE). The most commonly used vaccine used to prevent JE is the live-attenuated strain SA14-14-2, which was generated by serial passage of the wild-type (WT)
Externí odkaz:
https://doaj.org/article/76c97446ba9048d6a3eb3659558a8afe
Autor:
Yang Liu, Jianying Liu, Bryan A. Johnson, Hongjie Xia, Zhiqiang Ku, Craig Schindewolf, Steven G. Widen, Zhiqiang An, Scott C. Weaver, Vineet D. Menachery, Xuping Xie, Pei-Yong Shi
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110829- (2022)
Summary: We report that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta spike mutation P681R plays a key role in the Alpha-to-Delta variant replacement during the coronavirus disease 2019 (COVID-19) pandemic. Delta SARS-CoV-2 effic
Externí odkaz:
https://doaj.org/article/3196edde95424f02b77af3d57ed3c673
Autor:
Awadalkareem Adam, Camila R. Fontes-Garfias, Vanessa V. Sarathy, Yang Liu, Huanle Luo, Emily Davis, Wenqian Li, Antonio E. Muruato, Binbin Wang, Renat Ahatov, Yoseph Mahmoud, Chao Shan, Samantha R. Osman, Steven G. Widen, Alan D. T. Barrett, Pei-Yong Shi, Tian Wang
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract Although live attenuated vaccines (LAVs) have been effective in the control of flavivirus infections, to date they have been excluded from Zika virus (ZIKV) vaccine trials due to safety concerns. We have previously reported two ZIKV mutants,
Externí odkaz:
https://doaj.org/article/f28c37c48ce34bfaad88626bc97d5974
Autor:
Adam Hage, Preeti Bharaj, Sarah van Tol, Maria I. Giraldo, Maria Gonzalez-Orozco, Karl M. Valerdi, Abbey N. Warren, Leopoldo Aguilera-Aguirre, Xuping Xie, Steven G. Widen, Hong M. Moulton, Benhur Lee, Jeffrey R. Johnson, Nevan J. Krogan, Adolfo García-Sastre, Pei-Yong Shi, Alexander N. Freiberg, Ricardo Rajsbaum
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110434- (2022)
Summary: Type I interferons (IFN-I) are essential to establish antiviral innate immunity. Unanchored (or free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses. However, few unanchored poly-Ub interactors are known. To identify fact
Externí odkaz:
https://doaj.org/article/1021a0c2a2e14ca9810fefd46e1864bc
Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States
Autor:
Jennifer Harcourt, Azaibi Tamin, Xiaoyan Lu, Shifaq Kamili, Senthil K. Sakthivel, Janna Murray, Krista Queen, Ying Tao, Clinton R. Paden, Jing Zhang, Yan Li, Anna Uehara, Haibin Wang, Cynthia Goldsmith, Hannah A. Bullock, Lijuan Wang, Brett Whitaker, Brian Lynch, Rashi Gautam, Craig Schindewolf, Kumari G. Lokugamage, Dionna Scharton, Jessica A. Plante, Divya Mirchandani, Steven G. Widen, Krishna Narayanan, Shinji Makino, Thomas G. Ksiazek, Kenneth S. Plante, Scott C. Weaver, Stephen Lindstrom, Suxiang Tong, Vineet D. Menachery, Natalie J. Thornburg
Publikováno v:
Emerging Infectious Diseases, Vol 26, Iss 6, Pp 1266-1273 (2020)
The etiologic agent of an outbreak of pneumonia in Wuhan, China, was identified as severe acute respiratory syndrome coronavirus 2 in January 2020. A patient in the United States was given a diagnosis of infection with this virus by the state of Wash
Externí odkaz:
https://doaj.org/article/63ef0d21351e4e50abc9601ae3d9d991