Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Steven G Widen"'
Autor:
Minato Hirano, Gaddiel Galarza-Muñoz, Chloe Nagasawa, Geraldine Schott, Liuyang Wang, Alejandro L Antonia, Vaibhav Jain, Xiaoying Yu, Steven G Widen, Farren BS Briggs, Simon G Gregory, Dennis C Ko, William S Fagg, Shelton Bradrick, Mariano A Garcia-Blanco
Publikováno v:
eLife, Vol 12 (2023)
Genes associated with increased susceptibility to multiple sclerosis (MS) have been identified, but their functions are incompletely understood. One of these genes codes for the RNA helicase DExD/H-Box Polypeptide 39B (DDX39B), which shows genetic an
Externí odkaz:
https://doaj.org/article/c38f1aa37a0a4f6ba7bae9127557c87f
Autor:
Harris A Weisz, Deborah R Boone, William S Coggins, Gabrielle A Edwards, Hannah E Willey, Steven G Widen, Dionicio Siegel, Andrew T Nelson, Donald S Prough, Helen L Hellmich
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0267682 (2022)
Evaluating novel compounds for neuroprotective effects in animal models of traumatic brain injury (TBI) is a protracted, labor-intensive and costly effort. However, the present lack of effective treatment options for TBI, despite decades of research,
Externí odkaz:
https://doaj.org/article/c2f4f29b9cff4e3cb31ba283ea008f79
Autor:
Elizabeth Jaworski, Rose M Langsjoen, Brooke Mitchell, Barbara Judy, Patrick Newman, Jessica A Plante, Kenneth S Plante, Aaron L Miller, Yiyang Zhou, Daniele Swetnam, Stephanea Sotcheff, Victoria Morris, Nehad Saada, Rafael RG Machado, Allan McConnell, Steven G Widen, Jill Thompson, Jianli Dong, Ping Ren, Rick B Pyles, Thomas G Ksiazek, Vineet D Menachery, Scott C Weaver, Andrew L Routh
Publikováno v:
eLife, Vol 10 (2021)
High-throughput genomics of SARS-CoV-2 is essential to characterize virus evolution and to identify adaptations that affect pathogenicity or transmission. While single-nucleotide variations (SNVs) are commonly considered as driving virus adaption, RN
Externí odkaz:
https://doaj.org/article/4d7ebe7fd8ba48a3ba01181583b2b50c
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234185 (2020)
Early, ideally pre-symptomatic, recognition of common diseases (e.g., heart disease, cancer, diabetes, Alzheimer's disease) facilitates early treatment or lifestyle modifications, such as diet and exercise. Sensitive, specific identification of disea
Externí odkaz:
https://doaj.org/article/85797929f9244618b125b17893ca7d87
Autor:
Miguel A Saldaña, Kayvan Etebari, Charles E Hart, Steven G Widen, Thomas G Wood, Saravanan Thangamani, Sassan Asgari, Grant L Hughes
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005760 (2017)
Zika virus (ZIKV), a flavivirus transmitted primarily by Aedes aegypti, has recently spread globally in an unprecedented fashion, yet we have a poor understanding of host-microbe interactions in this system. To gain insights into the interplay betwee
Externí odkaz:
https://doaj.org/article/791b44c7340b439f98ea9c1de25347ad
Autor:
Nikita Sahadeo, Hamish Mohammed, Orchid M Allicock, Albert J Auguste, Steven G Widen, Kimberly Badal, Krishna Pulchan, Jerome E Foster, Scott C Weaver, Christine V F Carrington
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 12, p e0004305 (2015)
Externí odkaz:
https://doaj.org/article/cf1f9b62776348cf865352408b775a54
Autor:
Nikita Sahadeo, Hamish Mohammed, Orchid M Allicock, Albert J Auguste, Steven G Widen, Kimberly Badal, Krishna Pulchan, Jerome E Foster, Scott C Weaver, Christine V F Carrington
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 11, p e0004199 (2015)
Local transmission of Chikungunya virus (CHIKV) was first documented in Trinidad and Tobago (T&T) in July 2014 preceding a large epidemic. At initial presentation, it is difficult to distinguish chikungunya fever (CHIKF) from other acute undifferenti
Externí odkaz:
https://doaj.org/article/f1c571fcca7c4e0eac83b7c05016e677
Autor:
Peter J Walker, Cadhla Firth, Steven G Widen, Kim R Blasdell, Hilda Guzman, Thomas G Wood, Prasad N Paradkar, Edward C Holmes, Robert B Tesh, Nikos Vasilakis
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004664 (2015)
RNA viruses exhibit substantial structural, ecological and genomic diversity. However, genome size in RNA viruses is likely limited by a high mutation rate, resulting in the evolution of various mechanisms to increase complexity while minimising geno
Externí odkaz:
https://doaj.org/article/e5d6de170173494e86bec5bceed3a640
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 1, p e0003386 (2015)
Mosquito borne pathogens are transmitted to humans via saliva during blood feeding. Mosquito saliva is a complex concoction of many secretory factors that modulate the feeding foci to enhance pathogen infection and establishment. Multiple salivary pr
Externí odkaz:
https://doaj.org/article/7428553dd6cd4d54984d66e29622e38f
Autor:
Rasmussen, Ted G. Graber, Rosario Maroto, Jill K. Thompson, Steven G. Widen, Zhaohui Man, Megan L. Pajski, Blake B.
Publikováno v:
Journal of Ageing and Longevity; Volume 3; Issue 2; Pages: 159-178
One inevitable consequence of aging is the gradual deterioration of physical function and exercise capacity, driven in part by the adverse effect of age on muscle tissue. We hypothesized that relationships exist between age-related differentially exp