Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Steven G Rozen"'
Autor:
Gabriella Assante, Sriram Chandrasekaran, Stanley Ng, Aikaterini Tourna, Carolina H. Chung, Kowsar A. Isse, Jasmine L. Banks, Ugo Soffientini, Celine Filippi, Anil Dhawan, Mo Liu, Steven G. Rozen, Matthew Hoare, Peter Campbell, J. William O. Ballard, Nigel Turner, Margaret J. Morris, Shilpa Chokshi, Neil A. Youngson
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Background The incidence of non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing worldwide, but the steps in precancerous hepatocytes which lead to HCC driver mutations are not well understood. He
Externí odkaz:
https://doaj.org/article/4c59d9255acd4dbe97a0e6aee280b26c
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Mutational signatures are characteristic patterns of mutations generated by exogenous mutagens or by endogenous mutational processes. Mutational signatures are important for research into DNA damage and repair, aging, cancer biology, genetic
Externí odkaz:
https://doaj.org/article/1a915049c41a4a2fa8366715e23d7dca
Autor:
Gabriella Assante, Sriram Chandrasekaran, Stanley Ng, Aikaterini Tourna, Carolina H. Chung, Kowsar A. Isse, Jasmine L. Banks, Ugo Soffientini, Celine Filippi, Anil Dhawan, Mo Liu, Steven G. Rozen, Matthew Hoare, Peter Campbell, J. William O. Ballard, Nigel Turner, Margaret J. Morris, Shilpa Chokshi, Neil A. Youngson
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/eb93debd63754739be2c1d678c35747f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Protein binding microarrays provide comprehensive information about the DNA binding specificities of transcription factors (TFs), and can be used to quantitatively predict the effects of DNA sequence variation on TF binding. There has also b
Externí odkaz:
https://doaj.org/article/bf8428da735448df9592fa79a3a34db2
Autor:
Lai Fun Thean, Christopher Blöcker, Hui Hua Li, Michelle Lo, Michelle Wong, Choong Leong Tang, Emile K. W. Tan, Steven G. Rozen, Peh Yean Cheah
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Up-regulation of long non-coding RNAs (lncRNAs), colon-cancer associated transcript (CCAT) 1 and 2, was associated with worse prognosis in colorectal cancer (CRC). Nevertheless, their role in predicting metastasis in early-stage CRC is uncle
Externí odkaz:
https://doaj.org/article/217f5e9dbc8c4b8c9d80fdec8923ab21
Autor:
Sarinya Kongpetch, Apinya Jusakul, Jing Quan Lim, Cedric Chuan Young Ng, Jason Yongsheng Chan, Vikneswari Rajasegaran, Tse Hui Lim, Kiat Hon Lim, Su Pin Choo, Simona Dima, Irinel Popescu, Dan G. Duda, Veerapol Kukongviriyapan, Narong Khuntikeo, Chawalit Pairojkul, Steven G. Rozen, Patrick Tan, Bin Tean Teh
Publikováno v:
JCO Global Oncology, Vol , Iss 6, Pp 628-638 (2020)
PURPOSE Cholangiocarcinoma (CCA) remains a disease with poor prognosis and limited therapeutic options. Identification of driver genetic alterations may lead to the discovery of more effective targeted therapies. CCAs harboring FGFR2 fusions have rec
Externí odkaz:
https://doaj.org/article/10fa1389d83040b8a3bd96d6fb1d277e
SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events
Autor:
Erik N. Bergstrom, Mi Ni Huang, Uma Mahto, Mark Barnes, Michael R. Stratton, Steven G. Rozen, Ludmil B. Alexandrov
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Cancer genomes are peppered with somatic mutations imprinted by different mutational processes. The mutational pattern of a cancer genome can be used to identify and understand the etiology of the underlying mutational processes.
Externí odkaz:
https://doaj.org/article/15d692f5dc384868a0328f08ea0f4215
Autor:
Yew Chung Tang, Szu-Chi Ho, Elisabeth Tan, Alvin Wei Tian Ng, John R. McPherson, Germaine Yen Lin Goh, Bin Tean Teh, Frederic Bard, Steven G. Rozen
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-16 (2018)
Abstract Background Phosphatase and tensin homolog (PTEN) is one of the most frequently inactivated tumor suppressors in breast cancer. While PTEN itself is not considered a druggable target, PTEN synthetic-sick or synthetic-lethal (PTEN-SSL) genes a
Externí odkaz:
https://doaj.org/article/d5206bb396b84eb29668b60694b3e136
Autor:
Patrick Tan, Bin Tean Teh, Chawalit Pairojkul, Tatsuhiro Shibata, Steven G. Rozen, Raluca Gordân, Ludmil B. Alexandrov, Young Nyun Park, Hyungjin Rhee, André Luiz Vettore, André Lopes Carvalho, Di-Xian Luo, Jiaming Lai, Aldo Scarpa, Ming-Chin Yu, Sen-Yung Hsieh, Philippe Broet, Irinel Popescu, Dan G. Duda, Simona Dima, Kiat Hon Lim, London Lucien Peng Jin Ooi, Alexander Yaw Fui Chung, Pierce Kah-Hoe Chow, Satoshi Yamasaki, Yasuhito Arai, Hiromi Nakamura, Yasushi Totoki, Sopit Wongkham, Puangrat Yongvanit, Vajaraphongsa Bhudhisawasdi, Narong Khuntikeo, John R. McPherson, Jia Liang Loh, Jing Tan, Tse Hui Lim, Alvin Soon Tiong Lim, Stefanus Lie, Vikneswari Rajasegaran, Choon Kiat Ong, Mo Liu, Arnoud Boot, Cedric Chuan Young Ng, Weng Khong Lim, Sanjanaa Nagarajan, Raynoo Thanan, Swe Swe Myint, Su Pin Choo, Ley Moy Ng, Alvin Wei Tian Ng, Sarinya Kongpetch, Vishwa Nellore, Nisha Padmanabhan, Mi Ni Huang, Jing Quan Lim, Chern Han Yong, Ioana Cutcutache, Apinya Jusakul
Summary of Patients and Clinical Data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31eb3f353835bcfd1c8a3cf3c52e2f9d
https://doi.org/10.1158/2159-8290.22532000.v1
https://doi.org/10.1158/2159-8290.22532000.v1
Autor:
Patrick Tan, Bin Tean Teh, Jim R. Hughes, Gertrud Steger, Alexander Lezhava, David Lawrence Silver, Puay Hoon Tan, Kenneth Tou En Chang, Shang Li, Christopher Wai Sam Cheng, Iain Bee Huat Tan, Qiang Yu, Steven G. Rozen, Bryan C. Tan, Gary Loh, Jian Yuan Goh, James O. J. Davies, Swe Swe Myint, Chang Xu, Aditi Qamra, Tannistha Nandi, Joyce Suling Lin, Cassandra Zhengxuan He, Michelle Shu Wen Ng, Peiyong Guan, Ai Ping Lee-Lim, Jing Han Hong, Yue Ning Lam, Giovani Wijaya, Su Ting Tay, James Zhengzhong Qu, Yang Sun Chan, Manjie Xing, Dachuan Huang, Zhimei Li, Wen Fong Ooi, Joanna Koh, Kevin Junliang Lim, Jing Tan, Xiaosai Yao
Supplementary tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c483f4796a51a74e512b695e9ee4ed
https://doi.org/10.1158/2159-8290.22531964.v1
https://doi.org/10.1158/2159-8290.22531964.v1