Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Steven G Grinnell"'
Autor:
Rajendra Uprety, Tao Che, Saheem A Zaidi, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, András Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, Jonathan A Javitch, Jay P McLaughlin, Bryan L Roth, Gavril W Pasternak, Vsevolod Katritch, Susruta Majumdar
Publikováno v:
eLife, Vol 10 (2021)
Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal
Externí odkaz:
https://doaj.org/article/dc31183697a3454e95268139bbe3d9fd
Autor:
Andrew C. Kruegel, Rajendra Uprety, Steven G. Grinnell, Cory Langreck, Elizabeth A. Pekarskaya, Valerie Le Rouzic, Michael Ansonoff, Madalee M. Gassaway, John E. Pintar, Gavril W. Pasternak, Jonathan A. Javitch, Susruta Majumdar, Dalibor Sames
Publikováno v:
ACS Central Science, Vol 5, Iss 6, Pp 992-1001 (2019)
Externí odkaz:
https://doaj.org/article/971cb77fff204fd6a76409176ec31011
Autor:
Ying-Xian Pan, Andras Varadi, Gavril W. Pasternak, Joan J. Subrath, Amanda Hunkele, Susruta Majumdar, Rajendra Uprety, Steven G. Grinnell
Publikováno v:
Cell Mol Neurobiol
Mu opioid receptors (MOR-1) mediate the biological actions of clinically used opioids such as morphine, oxycodone, and fentanyl. The mu opioid receptor gene, OPRM1, undergoes extensive alternative splicing, generating multiple splice variants. One ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd285a387e4ab2ac4374c638883eab5a
https://doi.org/10.1007/s10571-020-00867-6
https://doi.org/10.1007/s10571-020-00867-6
Autor:
John E. Pintar, Brigitte L. Kieffer, Cory Langreck, Elizabeth A. Pekarskaya, Alexander Z. Harris, Steven G. Grinnell, Katherine M. Nautiyal, Florence Allain, Jaena Han, Valerie M. Magalong, Valentine Andreu, Jonathan A. Javitch, René Hen
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021, ⟨10.1038/s41386-021-01192-2⟩
Neuropsychopharmacology
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021, ⟨10.1038/s41386-021-01192-2⟩
Neuropsychopharmacology
Tianeptine is an atypical antidepressant used in Europe to treat patients who respond poorly to selective serotonin reuptake inhibitors (SSRIs). The recent discovery that tianeptine is a mu opioid receptor (MOR) agonist has provided a potential avenu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f43c2ef1072141f27ceffaf631c574
https://hal.archives-ouvertes.fr/hal-03408174
https://hal.archives-ouvertes.fr/hal-03408174
Autor:
John E. Pintar, Andrew C. Kruegel, Gavril W. Pasternak, Jonathan A. Javitch, Steven G. Grinnell, Madalee M. Gassaway, Dalibor Sames, Rajendra Uprety, Elizabeth A. Pekarskaya, Valerie Le Rouzic, Susruta Majumdar, Michael Ansonoff, Cory Langreck
Publikováno v:
ACS Central Science, Vol 5, Iss 6, Pp 992-1001 (2019)
Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction. Recently, growing use of the plant in the United
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::debf496a60baf3a050c65173399a74b3
https://doaj.org/article/971cb77fff204fd6a76409176ec31011
https://doaj.org/article/971cb77fff204fd6a76409176ec31011
Autor:
Samuel T. Slocum, Vsevolod Katritch, Rajendra Uprety, Joan J. Subrath, Jay P. McLaughlin, Gavril W. Pasternak, Ying Xian Pan, Amanda Hunkele, Valerie Le Rouzic, Melissa Nelson, Steven G. Grinnell, Abdelfattah Faouzi, András Váradi, Saheem A. Zaidi, Bryan L. Roth, Shainnel O. Eans, Balázs Varga, Elizaveta Kulko, Abdullah Allaoa, Tao Che, Susruta Majumdar, Sarah M Bernhard, Jonathan A. Javitch, Chloe A. Simons
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94dd6471e3351c062c3cc8a9d52004b
http://europepmc.org/articles/PMC7909954
http://europepmc.org/articles/PMC7909954
Autor:
Gavril W. Pasternak, Abdelfattah Faouzi, Bryan L. Roth, Amanda Hunkele, Steven G. Grinnell, Susruta Majumdar, Valerie Le Rouzic, Melissa Nelson, Sarah M Bernhard, Chloe A. Simons, Shainnel O. Eans, Samuel T. Slocum, Rajendra Uprety, Joan J. Subrath, András Váradi, Tao Che, Ying Xian Pan, Jonathan A. Javitch, Elizaveta Kulko, Vsevolod Katritch, Abdullah Allaoa, Saheem A. Zaidi, Balázs Varga, Jay P. McLaughlin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acf306e63c447f91f658560d8a55c64b
https://doi.org/10.7554/elife.56519.sa2
https://doi.org/10.7554/elife.56519.sa2
Autor:
Jessica M. Medina, Joan J. Subrath, Márton Richárd Szabó, Jay P. McLaughlin, Susruta Majumdar, Steven G. Grinnell, Gina F. Marrone, Sanjay Kalra, András Váradi, Jeremy Pagirsky, Ying-Xian Pan, Attila Borics, Jin Xu, Travis C. Palmer, Gavril W. Pasternak, Ankita Narayan, Valerie Le Rouzic, Shainnel O. Eans, Evelyn Warner, Amanda Hunkele
Publikováno v:
Journal of Medicinal Chemistry. 59:8381-8397
Natural products found in Mitragyna speciosa, commonly known as kratom, represent diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing opportunities to better understand opioid pharmacology. Herein, we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94a35e55b45ec92a90c2a69f4766534
https://doi.org/10.1021/acs.jmedchem.6b00748
https://doi.org/10.1021/acs.jmedchem.6b00748
Autor:
Ying-Xian Pan, Grace C. Rossi, John E. Pintar, Michael Ansonoff, Zhigang Lu, Ankita Narayan, Daniel L. Bassoni, Steven G. Grinnell, Jin Xu, Gina F. Marrone, Gavril W. Pasternak, Susruta Majumdar
Publikováno v:
Synapse. 70:395-407
Buprenorphine has long been classified as a mu analgesic, although its high affinity for other opioid receptor classes and the orphanin FQ/nociceptin ORL1 receptor may contribute to its other actions. The current studies confirmed a mu mechanism for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4248c6c20628aa06bc5af32bbc812a94
https://doi.org/10.1002/syn.21914
https://doi.org/10.1002/syn.21914
Autor:
Grace C. Rossi, Valerie Le Rouzic, Jin Xu, Susruta Majumdar, Gavril W. Pasternak, Gina F. Marrone, Zhigang Lu, Ying-Xian Pan, Steven G. Grinnell
Publikováno v:
Proceedings of the National Academy of Sciences. 113:3663-3668
The clinical management of severe pain depends heavily on opioids acting through mu opioid receptors encoded by the Oprm1 gene, which undergoes extensive alternative splicing. In addition to generating a series of prototypic seven transmembrane domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b085808aba5e6f0c887ead0d50b0e4
https://doi.org/10.1073/pnas.1523894113
https://doi.org/10.1073/pnas.1523894113