Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Steven G Clarke"'
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0296291 (2023)
The methionine addiction of cancer cells is known as the Hoffman effect. While non-cancer cells in culture can utilize homocysteine in place of methionine for cellular growth, most cancer cells require exogenous methionine for proliferation. It has b
Externí odkaz:
https://doaj.org/article/028a12d643d74df0a971ec94632fa16b
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285812 (2023)
Mammalian protein arginine methyltransferase 7 (PRMT7) has been shown to target substrates with motifs containing two arginine residues separated by one other residue (RXR motifs). In particular, the repression domain of human histone H2B (29-RKRSR-3
Externí odkaz:
https://doaj.org/article/21513c637b304d3eabb26d725d9c91d7
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65967 (2013)
Protein phosphatase 2A (PP2A), the major serine/threonine phosphatase in eukaryotic cells, is a heterotrimeric protein composed of structural, catalytic, and targeting subunits. PP2A assembly is governed by a variety of mechanisms, one of which is ca
Externí odkaz:
https://doaj.org/article/c2d67fc8b69d4097b4a96fbbb085cd2d
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46719 (2012)
L-isoaspartyl (D-aspartyl) O-methyltransferase deficient mice (Pcmt1(-/-)) accumulate isomerized aspartyl residues in intracellular proteins until their death due to seizures at approximately 45 days. Previous studies have shown that these mice have
Externí odkaz:
https://doaj.org/article/4e7b3c28318d4105a4284ff5380ca8b0
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29984 (2012)
The nematode Caenorhabditis elegans arrests development at the first larval stage if food is not present upon hatching. Larvae in this stage provide an excellent model for studying stress responses during development. We found that supplementing star
Externí odkaz:
https://doaj.org/article/1b1ac5761b3746e49fb2b262a2828b21
Autor:
Elena Lissina, Brian Young, Malene L Urbanus, Xue Li Guan, Jonathan Lowenson, Shawn Hoon, Anastasia Baryshnikova, Isabelle Riezman, Magali Michaut, Howard Riezman, Leah E Cowen, Markus R Wenk, Steven G Clarke, Guri Giaever, Corey Nislow
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002332 (2011)
Using small molecule probes to understand gene function is an attractive approach that allows functional characterization of genes that are dispensable in standard laboratory conditions and provides insight into the mode of action of these compounds.
Externí odkaz:
https://doaj.org/article/e357c09cbbfb4e029aa124f35878e3ef
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20850 (2011)
The protein L-isoaspartyl-O-methyltransferase functions to initiate the repair of isomerized aspartyl and asparaginyl residues that spontaneously accumulate with age in a variety of organisms. Caenorhabditis elegans nematodes lacking the pcm-1 gene e
Externí odkaz:
https://doaj.org/article/3b206b39e77e4c57bea68df1798a4154
Autor:
Jun Yamamoto, Sachiko Inubushi, Qinghong Han, Yoshihiko Tashiro, Norihiko Sugisawa, Kazuyuki Hamada, Yusuke Aoki, Kentaro Miyake, Ryusei Matsuyama, Michael Bouvet, Steven G. Clarke, Itaru Endo, Robert M. Hoffman
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104162- (2022)
Summary: Methionine addiction, found in all types of cancer investigated, is because of the overuse of methionine by cancer cells for excess transmethylation reactions. In the present study, we compared the histone H3 lysine-methylation status and de
Externí odkaz:
https://doaj.org/article/406428cf8097463ba54fc0fc565fe04d
Autor:
Mei-Ling Yang, Sean E. Connolly, Renelle J. Gee, TuKiet T. Lam, Jean Kanyo, Jian Peng, Perrin Guyer, Farooq Syed, Hubert M. Tse, Steven G. Clarke, Catherine F. Clarke, Eddie A. James, Cate Speake, Carmella Evans-Molina, Peter Arvan, Kevan C. Herold, Li Wen, Mark J. Mamula
Publikováno v:
Diabetes. 71:1979-1993
Inflammation and oxidative stress in pancreatic islets amplify the appearance of various posttranslational modifications to self-proteins. In this study, we identified a select group of carbonylated islet proteins arising before the onset of hypergly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67a360622f1aba1f9c3f3e1caa19f49
https://doi.org/10.2337/db21-0989
https://doi.org/10.2337/db21-0989
Autor:
Rebeccah A. Warmack, Eric Z. Pang, Esther Peluso, Jonathan D. Lowenson, Joseph Y. Ong, Jorge Z. Torres, Steven G. Clarke
Publikováno v:
Biochemistry
The spontaneous L-isoaspartate protein modification has been observed to negatively affect protein function. However, this modification can be reversed in many proteins in reactions initiated by the protein-L-isoaspartyl (D-aspartyl) O-methyltransfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb4d40718752685f8d461498a77a9a2
https://doi.org/10.1021/acs.biochem.2c00130
https://doi.org/10.1021/acs.biochem.2c00130