Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Steven G, Hughes"'
Autor:
Nhân Thị Hồ, Steven G. Hughes, Van Thanh Ta, Lân Trọng Phan, Quyết Đỗ, Thượng Vũ Nguyễn, Anh Thị Văn Phạm, Mai Thị Ngọc Đặng, Lượng Viết Nguyễn, Quang Vinh Trịnh, Hùng Ngọc Phạm, Mến Văn Chử, Toàn Trọng Nguyễn, Quang Chấn Lương, Vy Thị Tường Lê, Thắng Văn Nguyễn, Lý-Thi-Lê Trần, Anh Thi Van Luu, Anh Ngoc Nguyen, Nhung-Thi-Hong Nguyen, Hai-Son Vu, Jonathan M. Edelman, Suezanne Parker, Brian Sullivan, Sean Sullivan, Qian Ruan, Brenda Clemente, Brian Luk, Kelly Lindert, Dina Berdieva, Kat Murphy, Rose Sekulovich, Benjamin Greener, Igor Smolenov, Pad Chivukula, Vân Thu Nguyễn, Xuan-Hung Nguyen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Combination of waning immunity and lower effectiveness against new SARS-CoV-2 variants of approved COVID-19 vaccines necessitates new vaccines. We evaluated two doses, 28 days apart, of ARCT-154, a self-amplifying mRNA COVID-19 vaccine, comp
Externí odkaz:
https://doaj.org/article/78f337d895d0487e84e60fd454a0176c
Autor:
Jenny G. Low, Ruklanthi de Alwis, Shiwei Chen, Shirin Kalimuddin, Yan Shan Leong, Tania Ken Lin Mah, Natalene Yuen, Hwee Cheng Tan, Summer L. Zhang, Jean X. Y. Sim, Yvonne F. Z. Chan, Ayesa Syenina, Jia Xin Yee, Eugenia Z. Ong, Rose Sekulovich, Brian B. Sullivan, Kelly Lindert, Sean M. Sullivan, Pad Chivukula, Steven G. Hughes, Eng Eong Ooi
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Coronavirus disease-19 (Covid-19) pandemic have demonstrated the importantance of vaccines in disease prevention. Self-amplifying mRNA vaccines could be another option for disease prevention if demonstrated to be safe and immunogenic. Phase
Externí odkaz:
https://doaj.org/article/8f3f3b68e6d74f248a8f293e7fa6c66a
Autor:
Eugenia Z. Ong, Jia Xin Yee, Justin S. G. Ooi, Ayesa Syenina, Ruklanthi de Alwis, Shiwei Chen, Jean X. Y. Sim, Shirin Kalimuddin, Yan Shan Leong, Yvonne F. Z. Chan, Rose Sekulovich, Brian M. Sullivan, Kelly Lindert, Sean B. Sullivan, Pad Chivukula, Steven G. Hughes, Jenny G. Low, Eng Eong Ooi, Kuan Rong Chan
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Remarkable potency has been demonstrated for mRNA vaccines in reducing the global burden of the ongoing COVID-19 pandemic. An alternative form of the mRNA vaccine is the self-amplifying mRNA (sa-mRNA) vaccine, which encodes an alphavirus rep
Externí odkaz:
https://doaj.org/article/f164a1f335254aad9b2305f3200a7da5
Autor:
Matthew J. Reilley, Patricia McCoon, Carl Cook, Paul Lyne, Razelle Kurzrock, Youngsoo Kim, Richard Woessner, Anas Younes, John Nemunaitis, Nathan Fowler, Michael Curran, Qinying Liu, Tianyuan Zhou, Joanna Schmidt, Minji Jo, Samantha J. Lee, Mason Yamashita, Steven G. Hughes, Luis Fayad, Sarina Piha-Paul, Murali V. P. Nadella, Xiaokun Xiao, Jeff Hsu, Alexey Revenko, Brett P. Monia, A. Robert MacLeod, David S. Hong
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-10 (2018)
Abstract Background The Janus kinase (JAK) and signal transduction and activation of transcription (STAT) signaling pathway is an attractive target in multiple cancers. Activation of the JAK-STAT pathway is important in both tumorigenesis and activat
Externí odkaz:
https://doaj.org/article/f4f7c89c60164d3da2e398789b9d791f
Autor:
Eugene Schneider, Li-Jung Tai, Sebastien A. Burel, Padmakumar Narayanan, Joseph A. Tami, Lijiang Shen, Joseph L. Witztum, T. Jesse Kwoh, Scott P. Henry, Suzanne Paz, Brett P. Monia, Steven G. Hughes, Jeffery A Engelhardt, Sanford J. Shattil, Shuting Xia, Todd Machemer, Brian R. Curtis
Publikováno v:
Nucleic Acid Therapeutics. 30:94-103
Inotersen, a 2'-O-methoxyethyl (2'-MOE) phosphorothioate antisense oligonucleotide, reduced disease progression and improved quality of life in patients with hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) in the NEURO-TTR and NEU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3ffffb1daa283b051e7ec72a1e47a2
https://doi.org/10.1089/nat.2019.0829
https://doi.org/10.1089/nat.2019.0829
Autor:
Yvonne Fu Zi Chan, Eugenia Z. Ong, Yan Shan Leong, Kelly Lindert, Brian B Sullivan, Eng Eong Ooi, Ruklanthi de Alwis, Rose Sekulovich, Jia Xin Yee, Jenny G. Low, Shiwei Chen, Jean Siim, Summer L. Zhang, Shirin Kalimuddin, Pad Chivukula, Ayesa Syenina, Tania Mah, Hwee Cheng Tan, Sean M. Sullivan, Steven G Hughes, Natalene Yuen
BackgroundThe pandemic of coronavirus disease-19 (Covid-19) continues to afflict the lives and livelihoods of many as global demand for vaccine supply remains unmet.MethodsPhase 1 of this trial (N=42) assessed the safety, tolerability and immunogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00fc3b0dcf4a231ed451fc5c33ea2672
https://doi.org/10.1101/2021.07.01.21259831
https://doi.org/10.1101/2021.07.01.21259831
Autor:
Brett P. Monia, Steven G. Hughes, Marshelle S. Warren, Jason D. Ferrone, Gwendolyn E. Kaeser, Eugene Schneider, A. Robert MacLeod, Nicholas J. Viney, Brenda F. Baker, Alexey S. Revenko, Frederick Derosier, Gourab Bhattacharjee, Nguyen C. Pham, Thomas A. Zanardi
Publikováno v:
Nucleic Acid Therapeutics. 29:82-91
Kallikrein is the key contact system mediator responsible for the conversion of high-molecular-weight kininogen into the inflammatory vasodilator peptide bradykinin, a process regulated by C1-esterase inhibitor (C1-INH). In hereditary angioedema (HAE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969051625899292f6463ecc560f45748
https://doi.org/10.1089/nat.2018.0754
https://doi.org/10.1089/nat.2018.0754
Autor:
Asia Sikora Kessler, Thomas H. Brannagan, Laura Obici, Sami Khella, Andrew Lovley, Hartmut Schmidt, Steven G. Hughes, Michelle K. White, Michael Polydefkis, Teresa Coelho, Morie A. Gertz, Giampaolo Merlini, Michael L. Pollock, Spencer D. Guthrie, John L. Berk, P. James B. Dyck, Aaron Yarlas, Chafic Karam, Márcia Waddington-Cruz, Elizabeth J. Ackermann, Isabel Conceição, Merrill D. Benson
Publikováno v:
Journal of Neurology
Objective To examine the impact on quality of life (QOL) of patients with hATTR amyloidosis with polyneuropathy treated with inotersen (Tegsedi™) versus placebo. Methods Data were from the NEURO-TTR trial (ClinicalTrials.gov Identifier: NCT01737398
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea301c4808ed94febe373f953d68a57b
https://hdl.handle.net/10400.16/2665
https://hdl.handle.net/10400.16/2665
Autor:
Marcus V. Pinto, Márcia Waddington-Cruz, Linde E. Gove, Steven G. Hughes, Bryan M. McCauley, P. James B. Dyck, Elizabeth J. Ackermann, Peter J. Dyck
Publikováno v:
Journal of the Neurological Sciences. 394:78-83
Objective Report on the kind and distribution of somatotopic sensation loss and its utility in assessing severity of sensation loss in study of a large international cohort of patients with hereditary transthyretin amyloidosis with polyneuropathy (hA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae1f1b47e6a2ad8890b9de63fb37c5e
https://doi.org/10.1016/j.jns.2018.08.031
https://doi.org/10.1016/j.jns.2018.08.031
Autor:
T. Jesse Kwoh, Merrill D. Benson, Teresa Coelho, Brett P. Monia, Steven G. Hughes, John L. Berk, Annabel K. Wang, Stephen B. Heitner, Peter J. Dyck, Michael Polydefkis, Elizabeth J. Ackermann, Shiangtung W. Jung, Fabio Barroso, Li Tai, Morie A. Gertz, P. James B. Dyck, Márcia Waddington-Cruz
Publikováno v:
Amyloid. 25:180-188
Hereditary transthyretin (ATTRm) amyloidosis is a rare, progressive and fatal disease with a range of clinical manifestations.This study comprehensively evaluates disease characteristics in a large, diverse cohort of patients with ATTRm amyloidosis.A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9c81cd08803b7cb196351d4559093d
https://doi.org/10.1080/13506129.2018.1503593
https://doi.org/10.1080/13506129.2018.1503593