Zobrazeno 1 - 10
of 489
pro vyhledávání: '"Steven G, Gray"'
Autor:
Bandar Alharbi, Husam Qanash, Naif K. Binsaleh, Salem Alharthi, Abdulbaset M. Elasbali, Chandranil H. Gharekhan, Muhammad Mahmoud, Emmanouil Lioudakis, John J. O’Leary, Derek G. Doherty, Bashir M. Mohamed, Steven G. Gray
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Immunotherapies, including immune checkpoint inhibitors, have limitations in their effective treatment of malignancies. The immunosuppressive environment associated with the tumor microenvironment may prevent the achievement of optimal outco
Externí odkaz:
https://doaj.org/article/4178c51b295b40ccaac6b2f92dd5807d
Autor:
Tomer Meirson, Valerio Nardone, Francesca Pentimalli, Gal Markel, David Bomze, Maria D’Apolito, Pierpaolo Correale, Antonio Giordano, Luigi Pirtoli, Camillo Porta, Steven G Gray, Luciano Mutti
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-9 (2022)
Abstract In this commentary, using existing clinical trial data and FDA approvals we propose that there is currently a critical need for an appropriate balancing between the financial impact of new cancer drugs and their actual benefit for patients.
Externí odkaz:
https://doaj.org/article/31b55a1ccc204e26bbba66e8945e4d5e
Autor:
Luciano Mutti, Steven G. Gray
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/aa518c0a2569414bb99364c5efb36c98
Autor:
Jane S. Y. Sui, Petra Martin, Anna Keogh, Pierre Murchan, Lisa Ryan, Siobhan Nicholson, Sinead Cuffe, Pilib Ó Broin, Stephen P. Finn, Gerard J. Fitzmaurice, Ronan Ryan, Vincent Young, Steven G. Gray
Publikováno v:
BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-21 (2022)
Abstract Peroxisomes are organelles that play essential roles in many metabolic processes, but also play roles in innate immunity, signal transduction, aging and cancer. One of the main functions of peroxisomes is the processing of very-long chain fa
Externí odkaz:
https://doaj.org/article/6fa26683d81c4590aa498ee3f8dfdc69
Autor:
Ciara Murphy, Glòria Gornés Pons, Anna Keogh, Lisa Ryan, Lorraine McCarra, Chris Maria Jose, Shagun Kesar, Siobhan Nicholson, Gerard J. Fitzmaurice, Ronan Ryan, Vincent Young, Sinead Cuffe, Stephen P. Finn, Steven G. Gray
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2576 (2023)
The JADE family comprises three members encoded by individual genes and roles for these proteins have been identified in chromatin remodeling, cell cycle progression, cell regeneration and the DNA damage response. JADE family members, and in particul
Externí odkaz:
https://doaj.org/article/9c242364063e4fab8a70e318c7e0ee2b
Autor:
Steven G. Gray
Publikováno v:
BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-24 (2021)
Abstract Background The role of immunotherapy in cancer is now well-established, and therapeutic options such as checkpoint inhibitors are increasingly being approved in many cancers such as non-small cell lung cancer (NSCLC). Malignant pleural mesot
Externí odkaz:
https://doaj.org/article/98dc578fc01044e1aaa1564c0ab0a801
Autor:
Ezgi Oner, Mustafa Kotmakci, Anne-Marie Baird, Steven G. Gray, Bilge Debelec Butuner, Emir Bozkurt, Ayse Gulten Kantarci, Stephen P. Finn
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Background siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, and effective carrier
Externí odkaz:
https://doaj.org/article/dfd69785a72643ba9dfc925960946367
Autor:
Martin P. Barr, Anne-Marie Baird, Sophia Halliday, Petra Martin, Emma H. Allott, James Phelan, Greg Korpanty, Linda Coate, Cathal O’Brien, Steven G. Gray, Jane S. Y. Sui, Brian Hayes, Sinead Cuffe, Stephen P. Finn
Publikováno v:
Diagnostics, Vol 12, Iss 10, p 2360 (2022)
The liquid biopsy has the potential to improve patient care in the diagnostic and therapeutic setting in non-small cell lung cancer (NSCLC). Consented patients with epidermal growth factor receptor (EGFR) positive disease (n = 21) were stratified int
Externí odkaz:
https://doaj.org/article/57653e20063243da8a3fe1ac5629d75d
Autor:
Lauren MacDonagh, Rhyla Mae Santiago, Steven G. Gray, Eamon Breen, Sinead Cuffe, Stephen P. Finn, Kenneth J. O'Byrne, Martin P. Barr
Publikováno v:
Translational Oncology, Vol 14, Iss 4, Pp 101025- (2021)
Despite advances in personalised medicine and the emerging role of immune checkpoints in directing treatment decisions in subsets of lung cancer patients, non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related deaths world
Externí odkaz:
https://doaj.org/article/d6db2e7a64e74a76a7ad8670b42262fb
Autor:
John Greene, Anne-Marie Baird, Marvin Lim, Joshua Flynn, Ciara McNevin, Lauren Brady, Orla Sheils, Steven G. Gray, Raymond McDermott, Stephen P. Finn
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Circular RNAs (circRNAs), a recently discovered non-coding RNA, have a number of functions including the regulation of miRNA expression. They have been detected in a number of malignancies including prostate cancer (PCa). The differential expression
Externí odkaz:
https://doaj.org/article/c4da96b5b2c84ffeb845fcc574948456