Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Steven G, Booth"'
Autor:
Khiyam Hussain, Rena Liu, Rosanna C. G. Smith, Kri T. J. Müller, Mohammadmersad Ghorbani, Sofia Macari, Kirstie L. S. Cleary, Robert J. Oldham, Russell B. Foxall, Sonya James, Steven G. Booth, Tom Murray, Lekh N. Dahal, Chantal E. Hargreaves, Robert S. Kemp, Jemma Longley, James Douglas, Hannah Markham, Serena J. Chee, Richard J. Stopforth, Ali Roghanian, Matthew J. Carter, Christian H. Ottensmeier, Bjorn Frendéus, Ramsey I. Cutress, Ruth R. French, Martin J. Glennie, Jonathan C. Strefford, Stephen M. Thirdborough, Stephen A. Beers, Mark S. Cragg
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-32 (2022)
Abstract Background Hypoxia is a hallmark of the tumor microenvironment (TME) and in addition to altering metabolism in cancer cells, it transforms tumor-associated stromal cells. Within the tumor stromal cell compartment, tumor-associated macrophage
Externí odkaz:
https://doaj.org/article/4a2581bb496d4f649850cb54190883b9
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2022)
Bacterial infections are a common cause of morbidity and mortality in the elderly, and particularly in individuals with a neurodegenerative disease. Experimental models of neurodegeneration have shown that LPS-induced systemic inflammation increases
Externí odkaz:
https://doaj.org/article/21943c04dc8b43a6bbb51cbcc4b7e8c6
Autor:
C Ian Mockridge, H T Claude Chan, Mark S Cragg, Jinny Kim, Tatyana Inzhelevskaya, Jane E Willoughby, Julia Moreno-Vicente, Martin C Taylor, Steven G Booth, Vikki L English, Emily L Williams, Christine A Penfold, Juliet C Gray, Stephen A Beers
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/0d95105e612946869ce83db4c68db191
Autor:
Christian M. Orr, Hayden Fisher, Xiaojie Yu, Claude H.-T. Chan, Yunyun Gao, Patrick J. Duriez, Steven G. Booth, Isabel Elliott, Tatyana Inzhelevskaya, Ian Mockridge, Christine A. Penfold, Armin Wagner, Martin J. Glennie, Ann L. White, Jonathan W. Essex, Arwen R. Pearson, Mark S. Cragg, Ivo Tews
Publikováno v:
Science Immunology
Antibodies protect from infection, underpin successful vaccines and elicit therapeutic responses in otherwise untreatable cancers and autoimmune conditions. The human IgG2 isotype displays a unique capacity to undergo disulfide shuffling in the hinge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f26559ffaad774e3100f8f5c38f54b
https://pubmed.ncbi.nlm.nih.gov/35857582
https://pubmed.ncbi.nlm.nih.gov/35857582
Autor:
Julia Moreno-Vicente, Jane E Willoughby, Martin C Taylor, Steven G Booth, Vikki L English, Emily L Williams, Christine A Penfold, C Ian Mockridge, Tatyana Inzhelevskaya, Jinny Kim, H T Claude Chan, Mark S Cragg, Juliet C Gray, Stephen A Beers
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundDespite extensive clinical use, the mechanisms that lead to therapeutic resistance to anti-programmed cell-death (PD)-1 monoclonal antibodies (mAbs) remain elusive. Here, we sought to determine how interactions between the Fc region of anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc1d40f038ae30462935179ccdb7a35
https://jitc.bmj.com/content/10/1/e003735.full
https://jitc.bmj.com/content/10/1/e003735.full
Autor:
Xiaojie, Yu, H T Claude, Chan, Christian M, Orr, Osman, Dadas, Steven G, Booth, Lekh N, Dahal, Christine A, Penfold, Lyn, O'Brien, C Ian, Mockridge, Ruth R, French, Patrick, Duriez, Leon R, Douglas, Arwen R, Pearson, Mark S, Cragg, Ivo, Tews, Martin J, Glennie, Ann L, White
Publikováno v:
Cancer cell. 33(4)
Anti-CD40 monoclonal antibodies (mAbs) that promote or inhibit receptor function hold promise as therapeutics for cancer and autoimmunity. Rules governing their diverse range of functions, however, are lacking. Here we determined characteristics of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32a6fca115b636323fb246c1334d2566
https://pubmed.ncbi.nlm.nih.gov/29634942
https://pubmed.ncbi.nlm.nih.gov/29634942
Autor:
Björn Frendéus, Christine A. Penfold, Monika Semmrich, Emily L Williams, Steven G. Booth, Mats Jernetz, Anne Rogel, Ingrid Teige, Lekh N. Dahal, Jane E. Willoughby, Lang Dou, C. Ian Mockridge, J. Sjef Verbeek, Stuart N. Dunn, Kirstie L. S. Cleary, Juliet C. Gray, Chester Lai, Aymen Al-Shamkhani, Linda Mårtensson, Sarah L. Buchan, H.T. Claude Chan, Mark S. Cragg, Stephen A. Beers, Peter Johnson, Marcus Remer, Eugene Healy, Sonya James, Päivi Kannisto, Martin J. Glennie
Publikováno v:
Immunity. 49:958-970.e7
The costimulatory receptor 4-1BB is expressed on activated immune cells, including activated T cells. Antibodies targeting 4-1BB enhance the proliferation and survival of antigen-stimulated T cells in vitro and promote CD8 T cell-dependent anti-tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2971578b5fb5a1c4b51417d4ea86ef84
https://doi.org/10.1016/j.immuni.2018.09.014
https://doi.org/10.1016/j.immuni.2018.09.014
Autor:
Cherie L. Butts, Aymen Al-Shamkhani, Ann L. White, Ruth R. French, Mark S. Cragg, Emily L Williams, Stephen A. Beers, Peter Johnson, Martin J. Glennie, Elizabeth A. Potter, J. Sjef Verbeek, Lang Dou, Steven G. Booth, C. Ian Mockridge, Kane Moss, Vikki L Field, H.T. Claude Chan
Publikováno v:
Journal of Immunology, 193(4), 1828-1835
Immunomodulatory mAbs, led by the anti-CTLA4 mAb ipilimumab, are an exciting new class of drugs capable of promoting anticancer immunity and providing durable control of some tumors. Close analysis of a number of agents has revealed a critical yet va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e82a207940b88f0c8c8e92783ded68
https://hdl.handle.net/1887/104737
https://hdl.handle.net/1887/104737
Autor:
Ann L, White, H T Claude, Chan, Ruth R, French, Jane, Willoughby, C Ian, Mockridge, Ali, Roghanian, Christine A, Penfold, Steven G, Booth, Ali, Dodhy, Marta E, Polak, Elizabeth A, Potter, Michael R, Ardern-Jones, J Sjef, Verbeek, Peter W M, Johnson, Aymen, Al-Shamkhani, Mark S, Cragg, Stephen A, Beers, Martin J, Glennie
Publikováno v:
Cancer cell. 27(1)
Monoclonal antibody (mAb) drugs that stimulate antitumor immunity are transforming cancer treatment but require optimization for maximum clinical impact. Here, we show that, unlike other immunoglobulin isotypes, human IgG2 (h2) imparts FcγR-independ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d94f78d3c0795628bc3e7b74268cd617
https://pubmed.ncbi.nlm.nih.gov/25584890
https://pubmed.ncbi.nlm.nih.gov/25584890
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 9, Iss 1, p 146 (2012)
Journal of Neuroinflammation, Vol 9, Iss 1, p 146 (2012)
Background Systemic infection leads to generation of inflammatory mediators that result in metabolic and behavioural changes. Repeated or chronic systemic inflammation leads to a state of innate immune tolerance: a protective mechanism against overac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6135be6b08cfad79bddcb3ae323828
https://doi.org/10.1186/1742-2094-9-146
https://doi.org/10.1186/1742-2094-9-146