Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Steven Fikes"'
Autor:
George L Drusano, Michael Neely, Michael Van Guilder, Alan Schumitzky, David Brown, Steven Fikes, Charles Peloquin, Arnold Louie
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101311 (2014)
RationaleTuberculosis remains a worldwide problem, particularly with the advent of multi-drug resistance. Shortening therapy duration for Mycobacterium tuberculosis is a major goal, requiring generation of optimal kill rate and resistance-suppression
Externí odkaz:
https://doaj.org/article/1256c6075bff4f35aa29eb4d2784a757
Autor:
Haley Conde, Brian VanScoy, Sujata M. Bhavnani, Nicole E. Scangarella-Oman, Steven Fikes, Elizabeth A Lakota, Philippa Elefante, Paul G. Ambrose
Publikováno v:
Antimicrobial Agents and Chemotherapy
Gepotidacin is a novel, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by a distinct mechanism of action with an in vitro spectrum of activity that includes Escherichia coli. Our objectives herein were the foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead370c8c615c7bc3e543b21e5520054
https://doi.org/10.1128/aac.00122-21
https://doi.org/10.1128/aac.00122-21
Autor:
Sujata M. Bhavnani, Sharon Min, Nicole E. Scangarella-Oman, Karen A. Ingraham, Haley Conde, Jianzhong Huang, Paul G. Ambrose, Brian VanScoy, Steven Fikes
Publikováno v:
Antimicrobial Agents and Chemotherapy. 64
Multidrug-resistant Neisseria gonorrhoeae has emerged as a threat to global health. The relationship between gepotidacin exposure and prevention of on-therapy amplification of drug-resistant N. gonorrhoeae was examined using a 7-day hollow-fiber in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::987d495a268b632a6225f4205f428cf7
https://doi.org/10.1128/aac.00521-20
https://doi.org/10.1128/aac.00521-20
Autor:
Brian D, VanScoy, Nicole E, Scangarella-Oman, Steven, Fikes, Sharon, Min, Jianzhong, Huang, Karen, Ingraham, Sujata M, Bhavnani, Haley, Conde, Paul G, Ambrose
Publikováno v:
Antimicrobial agents and chemotherapy. 64(10)
Multidrug-resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b06876418d6d63dcce3f720f6312b2d
https://pubmed.ncbi.nlm.nih.gov/32661002
https://pubmed.ncbi.nlm.nih.gov/32661002
Autor:
Thomas R. Parr, Paul G. Ambrose, Brian VanScoy, Steven Fikes, Christopher M. Rubino, Ian A. Critchley, Sujata M. Bhavnani, Nicole Cotroneo
Publikováno v:
Open Forum Infectious Diseases
Background Tebipenem pivoxil hydrobromide (tebipenem HBr), an orally (PO) bioavailable prodrug of tebipenem, is a carbapenem with broad-spectrum activity against Gram-positive and -negative bacteria that is being developed for the treatment of patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb3abcf935a2a5e72fe92be2b6fcfa5
https://doi.org/10.1093/ofid/ofaa439.1487
https://doi.org/10.1093/ofid/ofaa439.1487
Autor:
Brian VanScoy, Paul G. Ambrose, John H. Adams, Christopher M. Rubino, Steven Fikes, Justin C Bader, Sujata M. Bhavnani
We previously demonstrated that the rate and extent of an antimicrobial agent's bactericidal effects were coupled to the bacterial replication rate, the latter of which was modulated with the sodium chloride concentration. Herein, we describe the res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca388d7f19f6ae8c0c038598dc26568
https://europepmc.org/articles/PMC5914008/
https://europepmc.org/articles/PMC5914008/
Autor:
Alan Schumitzky, Michael Neely, Steven Fikes, David Brown, Michael VanGuilder, Dodge Baluya, Arnold Louie, Roger W. Jelliffe, Stephanie Kurhanewicz, George L. Drusano, Weiguo Liu, Nichole Robbins
Publikováno v:
The Journal of Infectious Diseases. 211:1326-1333
Background. Meropenem plus levofloxacin treatment was shown to be a promising combination in our in vitro hollow fiber infection model. We strove to validate this finding in a murine Pseudomonas pneumonia model. Methods. A dose-ranging study with mer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0ca777c8a1f932945fba7387e50bf4
https://doi.org/10.1093/infdis/jiu603
https://doi.org/10.1093/infdis/jiu603
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:2788-2792
Pseudomonas aeruginosa pneumonia remains a difficult therapeutic problem. Optimal doses and modes of administration of single agents often do not result in acceptable outcomes. Further, emergence of resistance occurs frequently in this setting with s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483b4cf4a82fdf7d94f03fbcb5acbfd8
https://doi.org/10.1128/aac.02624-12
https://doi.org/10.1128/aac.02624-12
Autor:
Nadzeya Bahniuk, Brian VanScoy, Robert A. Bonomo, Robert Kulawy, Jürgen B. Bulitta, David Brown, George L. Drusano, Sarah M. Drawz, Arnold Louie, Holland DeFiglio, Steven Fikes
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:231-242
The panoply of resistance mechanisms in Pseudomonas aeruginosa makes resistance suppression difficult. Defining optimal regimens is critical. Cefepime is a cephalosporin whose 3′ side chain provides some stability against AmpC β-lactamases. We exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64a61312d427122499c5a0725c6c475
https://doi.org/10.1128/aac.05252-11
https://doi.org/10.1128/aac.05252-11
Autor:
Martina Kinzig-Schippers, Steven Fikes, Arnold Louie, Weiguo Liu, George L. Drusano, Brian VanScoy, David L. Brown, Fritz Sörgel, A. Eichas, K. Files, Henry S. Heine
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:822-830
Yersinia pestis , the causative agent of bubonic, septicemic, and pneumonic plague, is classified as a CDC category A bioterrorism pathogen. Streptomycin and doxycycline are the “gold standards” for the treatment of plague. However, streptomycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6183529459259a73a2b8c191f00abd
https://doi.org/10.1128/aac.00818-10
https://doi.org/10.1128/aac.00818-10