Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Steven F. Oliver"'
Autor:
Ji Qi, Yu-hong Lam, Adrian Goodyear, Jie Wang, Ed Cleator, Mahbub Alam, Mariko Morimoto, Andy Kirtley, Andrew D. Gibb, Steven F. Oliver, Stephen P. Keen, Matthew L. Maddess, Lingzhu Kong, Alejandro Dieguez-Vazquez, Xin Wen
Publikováno v:
Organic Process Research & Development. 26:640-647
Autor:
Steven F. Oliver, Eric R. Ashley, Christopher Wise, Robert K. Orr, Eric B. Sirota, Rebecca T. Ruck, Joseph F. Leone, Jamie M. McCabe Dunn, Andrew Nolting, Andrew W. Gibson, Alan M. Hyde, Jon A. Jurica
Publikováno v:
Green Chemistry. 20:2519-2525
Herein we describe the route scouting and process development efforts toward a green and sustainable synthesis of the HCV NS5b cyclic prodrug nucleoside (CPN) 1. Through the discovery and development of a crystallization-induced dynamic resolution an
Publikováno v:
Organic Process Research & Development. 21:1547-1556
A practical synthesis and detailed development process of 2H-1,3-benzoxazine derivatives catalyzed by aldimine and trifluoromethanesulfonic acid is described. A broad range of substrates with diverse steric and electronic properties were explored. Al
Autor:
David A. Nicewicz, Amruta Joshi-Pangu, Daniel A. DiRocco, Hudson G. Roth, Louis-Charles Campeau, Steven F. Oliver, François Lévesque
Publikováno v:
The Journal of Organic Chemistry. 81:7244-7249
The emergence of visible light photoredox catalysis has enabled the productive use of lower energy radiation, leading to highly selective reaction platforms. Polypyridyl complexes of iridium and ruthenium have served as popular photocatalysts in rece
Autor:
Andrew Nolting, Daniel Zewge, Jacob M. Janey, Zhiguo J. Song, David M. Tellers, Paul N. Devine, Steven F. Oliver, David M. Tschaen, Dietrich Steinhuebel, Peter G. Dormer
Publikováno v:
Organic Process Research & Development. 18:423-430
A practical synthesis of a macrocyclic HCV protease inhibitor, MK-1220, is described. The key features are a new synthesis of the trisubstituted isoquinoline, Sonogashira fragment coupling, and a high-yielding, 18-membered macrolactam formation.
Autor:
Steven F. Oliver, Alison Jo-Anne Woolford, Rebecca M. Myers, Søren Brøgger Christensen, Emily P. Balskus, Alessandra Antonello, Martin D. Smith, Oliver Simic, Steven V. Ley, David T. Booth, Udo Hünger, Ed Cleator, Helmer Søhoel, Helen Gold, Klemens Högenauer
The thapsigargins are a family of complex guaianolides with potent and selective Ca 2+ -modulating properties. This article documents the evolution of a synthetic route through several iterations to a final practical and scaleable synthetic route cap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6c2d778b3d4eb9ef819bebf61f921f
https://doi.org/10.1073/pnas.0403300101
https://doi.org/10.1073/pnas.0403300101
Autor:
Alan M. Hyde, Matthew T. Tudge, Qinghao Chen, Kevin R. Campos, Kevin M. Belyk, Jingjun Yin, Yining Ji, Louis-Charles Campeau, Steven F. Oliver, Hongming Li
Publikováno v:
ChemInform. 47
A novel approach to hemiaminal synthesis via palladium-catalyzed C–N coupling with chiral bisphosphine mono-oxides is described. This efficient new method exhibits a broad scope, provides a highly efficient synthesis of HCV drug candidate elbasvir,
Autor:
Robert D. Wilson, George Zhou, Antony J. Davies, Gavin W. Stewart, Karel M. J. Brands, David Hands, Steven F. Oliver, Michael S. Ashwood, Robert A. Reamer, Ed Cleator, Matthew M. Bio, Ulf-H. Dolling, Khateeta M. Emerson, Faye J. Sheen, Arlene E. Mckeown, Andrew D. Gibb
Publikováno v:
Organic Process Research & Development. 13:543-547
A practical and efficient synthesis of 1,4,5,6-tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole, 1, is described. A new one-pot process has been developed, starting from the commercially availa...
Autor:
Ulf-H. Dolling, Khateeta M. Emerson, Adrian Goodyear, Debra J. Wallace, Karel M. J. Brands, Steven F. Oliver, Cameron J. Cowden, Sarah E. Brewer, Michael S. Ashwood, Gavin W. Stewart, Jeremy P. Scott, Andrew D. Gibb
Publikováno v:
Organic Process Research & Development. 12:723-730
A practical asymmetric synthesis of the estrogen receptor beta selective agonist (7β-9aβ)-1,4-dichloro-2-hydroxygibba-1(10a),2,4,4b-tetraen-6-one (1), proceeding by way of six isolated intermediates and without recourse to chromatography, is descri
Autor:
Alan M. Hyde, Matthew T. Tudge, Kevin M. Belyk, Yining Ji, Qinghao Chen, Louis-Charles Campeau, Jingjun Yin, Steven F. Oliver, Hongming Li, Kevin R. Campos
Publikováno v:
Journal of the American Chemical Society. 137(43)
A novel approach to hemiaminal synthesis via palladium-catalyzed C–N coupling with chiral bisphosphine mono-oxides is described. This efficient new method exhibits a broad scope, provides a highly efficient synthesis of HCV drug candidate elbasvir,