Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Steven F. Abcouwer"'
Autor:
Steven F. Abcouwer, Bruna Miglioranza Scavuzzi, Phillip E. Kish, Dejuan Kong, Sumathi Shanmugam, Xuan An Le, Jingyu Yao, Heather Hager, David N Zacks
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract The retinal pigment epithelium (RPE) maintains photoreceptor viability and function, completes the visual cycle, and forms the outer blood-retinal barrier (oBRB). Loss of RPE function gives rise to several monogenic retinal dystrophies and c
Externí odkaz:
https://doaj.org/article/487206ebf56c47e6aeee4f489f4822ae
Autor:
Jérémie Canonica, Richard Foxton, Marina Garcia Garrido, Cheng-Mao Lin, Sabine Uhles, Sumathi Shanmugam, David A. Antonetti, Steven F. Abcouwer, Peter D. Westenskow
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionClinical trials demonstrated that co-targeting angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF-A) with faricimab controls anatomic outcomes and maintains vision improvements, with strong durability, through 2 years in
Externí odkaz:
https://doaj.org/article/eb987d4d51b2489f96e27b6a29635f5b
Autor:
Steven F. Abcouwer, Sumathi Shanmugam, Arivalagan Muthusamy, Cheng-mao Lin, Dejuan Kong, Heather Hager, Xuwen Liu, David A. Antonetti
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-26 (2021)
Abstract Background Several retinal pathologies exhibit both inflammation and breakdown of the inner blood-retinal barrier (iBRB) resulting in vascular permeability, suggesting that treatments that trigger resolution of inflammation may also promote
Externí odkaz:
https://doaj.org/article/419a66017cea427f86b1db8572b6afb8
Autor:
Patrice E. Fort, Thekkelnaycke M. Rajendiran, Tanu Soni, Jaeman Byun, Yang Shan, Helen C. Looker, Robert G. Nelson, Matthias Kretzler, George Michailidis, Jerome E. Roger, Thomas W. Gardner, Steven F. Abcouwer, Subramaniam Pennathur, Farsad Afshinnia
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
BACKGROUND This study systematically investigated circulating and retinal tissue lipid determinants of human diabetic retinopathy (DR) to identify underlying lipid alterations associated with severity of DR.METHODS Retinal tissues were retrieved from
Externí odkaz:
https://doaj.org/article/dbaa7f52a5e1422898c64c6489cc2f2b
Autor:
Kelli M. Sas, Jiahe Lin, Thekkelnaycke M. Rajendiran, Tanu Soni, Viji Nair, Lucy M. Hinder, Hosagrahar V. Jagadish, Thomas W. Gardner, Steven F. Abcouwer, Frank C. Brosius, III, Eva L. Feldman, Matthias Kretzler, George Michailidis, Subramaniam Pennathur
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 173-183 (2018)
Lipids are ubiquitous metabolites with diverse functions; abnormalities in lipid metabolism appear to be related to complications from multiple diseases, including type 2 diabetes. Through technological advances, the entire lipidome has been characte
Externí odkaz:
https://doaj.org/article/ba85df96d23e4dfc9895cf6bfd30b5d5
Autor:
Bing X. Ross, Lin Jia, Dejuan Kong, Tiantian Wang, Heather M. Hager, Steven F. Abcouwer, David N. Zacks
Publikováno v:
Cells, Vol 10, Iss 8, p 2010 (2021)
After retinal detachment (RD), the induction of autophagy protects photoreceptors (PR) from apoptotic cell death. The cytoplasmic high-mobility group box 1 (HMGB1) promotes autophagy. We previously demonstrated that the deletion of HMGB1 from rod PRs
Externí odkaz:
https://doaj.org/article/53b1126dcf584204b32b40395a0911cf
Autor:
Stephanie A. Eid, Phillipe D. O’Brien, Lucy M. Hinder, John M. Hayes, Faye E. Mendelson, Hongyu Zhang, Lixia Zeng, Katharina Kretzler, Samanthi Narayanan, Steven F. Abcouwer, Frank C. Brosius, Subramaniam Pennathur, Masha G. Savelieff, Eva L. Feldman
Publikováno v:
Biology, Vol 9, Iss 11, p 347 (2020)
Microvascular complications account for the significant morbidity associated with diabetes. Despite tight glycemic control, disease risk remains especially in type 2 diabetes (T2D) patients and no therapy fully prevents nerve, retinal, or renal damag
Externí odkaz:
https://doaj.org/article/ae980c3ab17d496ca000323a2cc2eade
Autor:
Bing X, Ross, Lin, Jia, Dejuan, Kong, Tiantian, Wang, Jingyu, Yao, Heather M, Hager, Steven F, Abcouwer, David N, Zacks
Publikováno v:
Investigative Opthalmology & Visual Science. 63:7
Following retinal detachment (RD) photoreceptors (PRs) sustain hypoxic stress and eventually die. Hypoxia-inducible factor-1α (HIF-1α) plays a central role in cellular adaptation to hypoxia. The purpose of this study is to determine the necessity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c9ea056f4cbfa3a52562d008dc2d24
https://doi.org/10.1167/iovs.63.11.7
https://doi.org/10.1167/iovs.63.11.7
Autor:
Patrice E. Fort, Mandy K. Losiewicz, Lynda Elghazi, Dejuan Kong, Corentin Cras-Méneur, Diane C. Fingar, Scot R. Kimball, Raju V.S. Rajala, Alexander J. Smith, Robin R. Ali, Steven F. Abcouwer, Thomas W. Gardner
Publikováno v:
The Journal of biological chemistry. 298(6)
Mechanistic target of rapamycin (mTOR) and mTOR complex 1 (mTORC1), linchpins of the nutrient sensing and protein synthesis pathways, are present at relatively high levels in the ganglion cell layer (GCL) and retinal ganglion cells (RGCs) of rodent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72e56c86d0cfd71cc78e0799efc3085
https://pubmed.ncbi.nlm.nih.gov/35447116
https://pubmed.ncbi.nlm.nih.gov/35447116
Autor:
Eva L. Feldman, Patrice Fort, Steven F. Abcouwer, Kelli M. Sas, Thomas W. Gardner, Stephanie Eid, Subramaniam Pennathur
Publikováno v:
Diabetologia
Diabetes adversely affects multiple organs, including the kidney, eye and nerve, leading to diabetic kidney disease, diabetic retinopathy and diabetic neuropathy, respectively. In both type 1 and type 2 diabetes, tissue damage is organ specific and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc86fff7975c96e9c3ce0a7174dfe90f
https://doi.org/10.1007/s00125-019-4959-1
https://doi.org/10.1007/s00125-019-4959-1