Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Steven F Dowdy"'
Autor:
Naohisa Yoshioka, Steven F Dowdy
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0182018 (2017)
We previously devised a polycistronic, synthetic self-replicating RNA (srRNA) to generate human induced Pluripotent Stem Cells (iPSCs) that simultaneously expresses four reprogramming factors (4F). However, while the best 4F srRNA efficiently generat
Externí odkaz:
https://doaj.org/article/edf32290e518463bbe570bdfb86685d4
Autor:
Anil M Narasimha, Manuel Kaulich, Gary S Shapiro, Yoon J Choi, Piotr Sicinski, Steven F Dowdy
Publikováno v:
eLife, Vol 3 (2014)
The widely accepted model of G1 cell cycle progression proposes that cyclin D:Cdk4/6 inactivates the Rb tumor suppressor during early G1 phase by progressive multi-phosphorylation, termed hypo-phosphorylation, to release E2F transcription factors. Ho
Externí odkaz:
https://doaj.org/article/eee3aeb5715d4b63a87c2a1863752d05
Autor:
Michelle V Wagner, Marcus B Smolka, Rob A M de Bruin, Huilin Zhou, Curt Wittenberg, Steven F Dowdy
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4300 (2009)
The Whi5 transcriptional repressor is a negative regulator of G1 cell cycle progression in Saccharomyces cerevisiae and is functionally equivalent to the Retinoblastoma (Rb) tumor suppressor protein in mammals. In early G1, Whi5 binds to and inhibits
Externí odkaz:
https://doaj.org/article/91f47ffab85c4cb5a6a1668e3bab7c94
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3314 (2008)
Transmissible spongiform encephalopathies, including variant-Creutzfeldt-Jakob disease (vCJD) in humans and bovine spongiform encephalopathies in cattle, are fatal neurodegenerative disorders characterized by protein misfolding of the host cellular p
Externí odkaz:
https://doaj.org/article/eae95a23e6e443c9a3161a5ec9850fb2
Publikováno v:
PLoS Biology, Vol 2, Iss 2, p E36 (2004)
Advanced-stage peritoneal carcinomatosis is resistant to current chemotherapy treatment and, in the case of metastatic ovarian cancer, results in a devastating 15%-20% survival rate. Therapeutics that restore genes inactivated during oncogenesis are
Externí odkaz:
https://doaj.org/article/fab6022f0c6447b483b25ec9c98521cf
Publikováno v:
Nucleic Acid Therapeutics. 32:361-368
RNA therapeutics, including siRNAs, antisense oligonucleotides, and other oligonucleotides, have great potential to selectively treat a multitude of human diseases, from cancer to COVID to Parkinson's disease. RNA therapeutic activity is mechanistica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e2b637a317791783e4bef2db2604f3
https://doi.org/10.1089/nat.2022.0004
https://doi.org/10.1089/nat.2022.0004
Autor:
Ari Melnick, Steven F. Dowdy, Randy D. Gascoyne, Rita Shaknovich, Pedro Farinha, Gustavo F. Da Silva, Jose M. Polo, Leandro C. Cerchietti
Supplementary Materials from Sequential Transcription Factor Targeting for Diffuse Large B-Cell Lymphomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fefd41ad181a581cfb95663d4450f31
https://doi.org/10.1158/0008-5472.22376628
https://doi.org/10.1158/0008-5472.22376628
Autor:
Ryan L. Setten, Steven F. Dowdy
Publikováno v:
Molecular Therapy - Nucleic Acids. 29:133-134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f53aad365e374f91e0ba6a75a4f3a7
https://doi.org/10.1016/j.omtn.2022.06.013
https://doi.org/10.1016/j.omtn.2022.06.013
Autor:
Ronald K. June, Martin Lotz, Steven F. Dowdy, Akiko Eguchi, Sabrina E. Dinkel, Sarah E. Mailhiot, Matthew A. Thompson
Publikováno v:
Cartilage
Objective Intra-articular drug delivery holds great promise for the treatment of joint diseases such as osteoarthritis. The objective of this study was to evaluate the TAT peptide transduction domain (TAT-PTD) as a potential intra-articular drug deli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2753b8351abc66c60db2a1b9e6d93eb8
https://doi.org/10.1177/1947603520959392
https://doi.org/10.1177/1947603520959392
Autor:
Alexander S. Hamil, Linda Vidarsdottir, Oksana Goroshchuk, Steven F. Dowdy, Ann-Charlotte Björklund, Caroline Palm-Apergi, Iryna Kolosenko
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
B-cell acute lymphoblastic leukemia (B-ALL) accounts for nearly one fifth of all childhood cancers and current challenges in B-ALL treatment include resistance, relapse and late-onset side effects due to the chemotherapy. To overcome these hurdles, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac426e2e93072b4dc807e1cd9454963f
http://link.springer.com/article/10.1038/s41598-020-59653-5
http://link.springer.com/article/10.1038/s41598-020-59653-5