Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Steven F, Dowdy"'
Autor:
Manuel Kaulich, Verena M. Link, John D. Lapek, Yeon J. Lee, Christopher K. Glass, David J. Gonzalez, Steven F. Dowdy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract During early G1 phase, Rb is exclusively mono-phosphorylated by cyclin D:Cdk4/6, generating 14 different isoforms with specific binding patterns to E2Fs and other cellular protein targets. While mono-phosphorylated Rb is dispensable for earl
Externí odkaz:
https://doaj.org/article/d7d64e91293648eb929fa5c8632d7b65
Autor:
Ryan L. Setten, Steven F. Dowdy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 133-134 (2022)
Externí odkaz:
https://doaj.org/article/1f2f8fff984d47c0a305def405079a9e
Publikováno v:
Nucleic Acid Therapeutics. 32:361-368
RNA therapeutics, including siRNAs, antisense oligonucleotides, and other oligonucleotides, have great potential to selectively treat a multitude of human diseases, from cancer to COVID to Parkinson's disease. RNA therapeutic activity is mechanistica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e2b637a317791783e4bef2db2604f3
https://doi.org/10.1089/nat.2022.0004
https://doi.org/10.1089/nat.2022.0004
Autor:
Ari Melnick, Steven F. Dowdy, Randy D. Gascoyne, Rita Shaknovich, Pedro Farinha, Gustavo F. Da Silva, Jose M. Polo, Leandro C. Cerchietti
Supplementary Materials from Sequential Transcription Factor Targeting for Diffuse Large B-Cell Lymphomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fefd41ad181a581cfb95663d4450f31
https://doi.org/10.1158/0008-5472.22376628
https://doi.org/10.1158/0008-5472.22376628
Autor:
Naohisa Yoshioka, Steven F Dowdy
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0182018 (2017)
We previously devised a polycistronic, synthetic self-replicating RNA (srRNA) to generate human induced Pluripotent Stem Cells (iPSCs) that simultaneously expresses four reprogramming factors (4F). However, while the best 4F srRNA efficiently generat
Externí odkaz:
https://doaj.org/article/edf32290e518463bbe570bdfb86685d4
Autor:
Ian J. Huggins, Carlos A. Medina, Aaron D. Springer, Arjen van den Berg, Satish Jadhav, Xianshu Cui, Steven F. Dowdy
Publikováno v:
Molecules, Vol 24, Iss 18, p 3287 (2019)
Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy an
Externí odkaz:
https://doaj.org/article/6bc3e3a97c074421a5e994cf803fcfd5
Autor:
Ronald K. June, Martin Lotz, Steven F. Dowdy, Akiko Eguchi, Sabrina E. Dinkel, Sarah E. Mailhiot, Matthew A. Thompson
Publikováno v:
Cartilage
Objective Intra-articular drug delivery holds great promise for the treatment of joint diseases such as osteoarthritis. The objective of this study was to evaluate the TAT peptide transduction domain (TAT-PTD) as a potential intra-articular drug deli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2753b8351abc66c60db2a1b9e6d93eb8
https://doi.org/10.1177/1947603520959392
https://doi.org/10.1177/1947603520959392
Autor:
Alexander S. Hamil, Linda Vidarsdottir, Oksana Goroshchuk, Steven F. Dowdy, Ann-Charlotte Björklund, Caroline Palm-Apergi, Iryna Kolosenko
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
B-cell acute lymphoblastic leukemia (B-ALL) accounts for nearly one fifth of all childhood cancers and current challenges in B-ALL treatment include resistance, relapse and late-onset side effects due to the chemotherapy. To overcome these hurdles, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac426e2e93072b4dc807e1cd9454963f
http://link.springer.com/article/10.1038/s41598-020-59653-5
http://link.springer.com/article/10.1038/s41598-020-59653-5
Autor:
Jonathan D. Geiger, Nabab Khan, Koffi L. Lakpa, Nicole M. Miller, Zahra Afghah, Peter W. Halcrow, Xuesong Chen, Steven F. Dowdy
Publikováno v:
The FASEB Journal
HIV‐1 Tat is essential for HIV‐1 replication and appears to play an important role in the pathogenesis of HIV‐associated neurological complications. Secreted from infected or transfected cells, Tat has the extraordinary ability to cross the pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b898e13c769d964d4d066dd3e2205e7a
https://doi.org/10.1096/fj.201902534r
https://doi.org/10.1096/fj.201902534r
Autor:
Satish Jadhav, Steven F. Dowdy
Publikováno v:
Nature Materials. 20:575-577
Ionizable phospholipids have been developed to enhance the delivery of mRNA and sgRNA for gene editing by selective organ targeting and endosomal membrane destabilization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d6ad263231309a830dd16adb925605c
https://doi.org/10.1038/s41563-021-00988-3
https://doi.org/10.1038/s41563-021-00988-3