Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Steven Estus"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Traumatic brain injury (TBI) increases gastrointestinal morbidity and associated mortality. Clinical and preclinical studies implicate gut dysbiosis as a consequence of TBI and an amplifier of brain damage. However, little is known about the
Externí odkaz:
https://doaj.org/article/961f185d97ab437cba8613e2aa448413
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Apolipoprotein E (APOE) alleles impact pathogenesis and risk for multiple human diseases, making them primary targets for disease treatment and prevention. Previously, we and others reported an association between APOE alleles and the gut mi
Externí odkaz:
https://doaj.org/article/912cb66cf2f246248f163c42787ddf53
Autor:
Pierre De Rossi, Virginie Buggia-Prévot, Benjamin L. L. Clayton, Jared B. Vasquez, Carson van Sanford, Robert J. Andrew, Ruben Lesnick, Alexandra Botté, Carole Deyts, Someya Salem, Eshaan Rao, Richard C. Rice, Angèle Parent, Satyabrata Kar, Brian Popko, Peter Pytel, Steven Estus, Gopal Thinakaran
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/ddafc8cc4fce4f2296415a22e72b3b17
Autor:
Diana J. Zajac, Benjamin C. Shaw, David J. Braun, Stefan J. Green, Joshua M. Morganti, Steven Estus
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Elucidating the impact of the gut microbiome on Alzheimer’s Disease (AD) is an area of intense interest. Short chain fatty acids (SCFAs) are major microbiota metabolites that have been implicated as a mediator of gut microbiome effects in the brain
Externí odkaz:
https://doaj.org/article/0e0f9a3173cb4dbe9d911738d6da7bba
Autor:
Juan Maldonado Weng, Ishita Parikh, Ankur Naqib, Jason York, Stefan J. Green, Steven Estus, Mary Jo LaDu
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-9 (2019)
Abstract Background Alzheimer’s disease (AD) is a fatal neurodegenerative disease. APOE4 is the greatest genetic risk factor for AD, increasing risk up to 15-fold compared to the common APOE3. Importantly, female (♀) APOE4 carriers have a greater
Externí odkaz:
https://doaj.org/article/d8eeb3b3e50d46efa93f3f0cf1e2e7f6
Autor:
Ishita J. Parikh, Janice L. Estus, Diana J. Zajac, Manasi Malik, Juan Maldonado Weng, Leon M. Tai, George E. Chlipala, Mary Jo LaDu, Stefan J. Green, Steven Estus
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: Since APOE alleles represent the most impactful genetic risk factors for Alzheimer's disease (AD), their differential mechanism(s) of action are under intense scrutiny. APOE4 is robustly associated with increased AD risk compared to the n
Externí odkaz:
https://doaj.org/article/26645987dc4d42a28f6af9e70b58d52c
Autor:
Jitbanjong Tangpong, Marsha P. Cole, Rukhsana Sultana, Gururaj Joshi, Steven Estus, Mary Vore, William St. Clair, Suvina Ratanachaiyavong, Daret K. St. Clair, D. Allan Butterfield
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 1, Pp 127-139 (2006)
The clinical effectiveness of adriamycin (ADR), a potent chemotherapeutic, is known to be limited by severe cardiotoxic side effects. However, the effect of ADR on brain tissue is not well understood. It is generally thought that ADR is not toxic to
Externí odkaz:
https://doaj.org/article/0a3912b7faeb49c4b884838944348268
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91242 (2014)
Novel Alzheimer's disease (AD) risk factors have been identified by genome-wide association studies. Elucidating the mechanism underlying these factors is critical to the validation process and, by identifying rate-limiting steps in AD risk, may yiel
Externí odkaz:
https://doaj.org/article/539952d6005c419a81a4841fa17cbc73
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e33923 (2012)
The minor allele of rs11136000 within CLU is strongly associated with reduced Alzheimer's disease (AD) risk. The mechanism underlying this association is unclear. Here, we report that CLU1 and CLU2 are the two primary CLU isoforms in human brain; CLU
Externí odkaz:
https://doaj.org/article/99ee7dac0e6d4d618827f496ed6cc3a5
Autor:
Sangderk Lee, Holden C. Williams, Amy A. Gorman, Nicholas A. Devanney, Douglas A. Harrison, Adeline E. Walsh, Danielle S. Goulding, Tony Tuck, James L. Schwartz, Diana J. Zajac, Shannon L. Macauley, Steven Estus, TCW Julia, Lance A. Johnson, Josh M. Morganti
Publikováno v:
bioRxiv
SummaryApolipoprotein E4 (APOE4) is the strongest risk allele associated with the development of late onset Alzheimer’s disease (AD). Across the CNS, astrocytes are the predominant expressor ofAPOEwhile also being critical mediators of neuroinflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbb7b96ff691f012d4c3107889a13e7
https://europepmc.org/articles/PMC9934552/
https://europepmc.org/articles/PMC9934552/