Výsledky vyhledávání - "Steven England"

In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists

Autor: William A. Million, Pauline Carnell, Gareth W. Harbottle, Russell Monhemius, Simon A. Osborne, Cedric Poinsard, Maw Graham Nigel, Ben S. Greener, Karl Richard Gibson, Rebecca L. Prime, Steven England, Peter G. Dodd, Simon John Mantell, Alison Betts, Huw Rees

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:2190-2194

The SAR of a series of novel pyrido[3,4-d]pyramid-4-ylamine mGluR1 antagonists is described. The multiple of the unbound K(i) in cerebrospinal fluid necessary to give morphine like analgesic effects in an electromyograph pinch model in rodents is det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedc2e644ebe905bda97f0d735bbb991
https://doi.org/10.1016/j.bmcl.2009.02.106

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Identification of the α 2 -δ-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin

Autor: Steve Bramwell, Emma Stott, Heather L. Melrose, Joanna S Winks, Ross A. Kinloch, Laura Corradini, Dic Williams, Jan Hendrich, Ti-Zhi Su, Peter J. Cox, James Offord, Tony Webb, Steven England, Annette C. Dolphin, Mark J. Field

Publikováno v: Proceedings of the National Academy of Sciences. 103:17537-17542

Neuropathic pain is a debilitating condition affecting millions of people around the world and is defined as pain that follows a lesion or dysfunction of the nervous system. This type of pain is difficult to treat, but the novel compounds pregabalin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674330ad32d2321e8bb4bff2eb886676
https://doi.org/10.1073/pnas.0409066103

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The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

Autor: Anthony H. Dickenson, Nobukuni Ogata, Kenji Okuse, Armen N. Akopian, Bradley J. Kerr, Veronika Souslova, Louise C. Stanfa, Sue Boyce, Jan Ure, Raymond G. Hill, Andrew J.H. Smith, Steven England, John N. Wood, Steven B. McMahon

Publikováno v: Nature Neuroscience. 2:541-548

Many damage-sensing neurons express tetrodotoxin (TTX)-resistant voltage-gated sodium channels. Here we examined the role of the sensory-neuron-specific (SNS) TTX-resistant sodium channel alpha subunit in nociception and pain by constructing sns-null

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a892fcabad4ed1182b335e12780e31d6
https://doi.org/10.1038/9195

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Trans-splicing of a voltage-gated sodium channel is regulated by nerve growth factor

Autor: Veronika Souslova, Steven England, Armen N. Akopian, Kenji Okuse, Nobukino Ogata, John N. Wood

Publikováno v: FEBS Letters. 445:177-182

Mammalian sensory neurons express a voltage-gated sodium channel named SNS. Here we report the identification of an SNS transcript (SNS-A) that contains an exact repeat of exons 12, 13 and 14 encoding a partial repeat of domain II. Because the exons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3cb00d9e61c6fdacd97fdfc8d9b41ab
https://doi.org/10.1016/s0014-5793(99)00126-x

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A sensory neuron-specific, proton-gated ion channel

Autor: Chih-Cheng Chen, Steven England, John N. Wood, Armen N. Akopian

Proton-gated channels expressed by sensory neurons are of particular interest because low pH causes pain. Two proton-gated channels, acid-sensing ionic channel (ASIC) and dorsal root ASIC (DRASIC), that are members of the amiloride-sensitive ENaC/Deg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240e36ae417effd481bfb8b6f74e50b0
https://europepmc.org/articles/PMC21492/

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Assay Development And Screening For Modulators Of The Human Two-pore Domain Potassium Channel, TASK-3, Using Automated Electrophysiology

Autor: Rebecca Prime, Matthew Gardener, Andrew Southan, Scott A. Maidment, Tristana von Will, Steven England, Gary Clark, Edward Stevens, Elizabeth Payne

Publikováno v: Biophysical Journal. (3):672a

The advent of high-throughput electrophysiology utilizing Population Patch Clamp™ (PPC) technology has allowed the screening of large compound libraries against ion channels representing novel targets in a variety of disease states. Here we report

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