Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Steven Einheber"'
Autor:
Gerard Fejes-Toth, Aniko Naray Fejes-Toth, Florian Lang, Steven Einheber, James L. Salzer, Grant Morahan, Maria Laura Feltri, Luba Kalaydjieva, Ethan M. Grund, Bradley A. Heller, Monica Ghidinelli, Ryan Smith, Jakob Voelkl, Rosalind H.M. King, David Chandler, Filippo G. Giancotti
Publikováno v:
The Journal of Cell Biology
Functionally and spatially distinct PI 3-K pathways act either early to promote myelination downstream of axonal Neuregulin1 or late to inhibit myelination downstream of α6β4 integrin and Sgk1.
The PI 3-kinase (PI 3-K) signaling pathway is ess
The PI 3-kinase (PI 3-K) signaling pathway is ess
Autor:
Peter Shrager, Patrice Maurel, Xiaosong Meng, Joseph L. Kissil, Isabel Lam, Narla Mohandas, Xiuli An, Steven Einheber, James L. Salzer, Marina Rubin
Publikováno v:
Glia. 61:240-253
Myelinated axons are organized into specialized domains critical to their function in saltatory conduction, i.e. nodes, paranodes, juxtaparanodes, and internodes. Here, we describe the distribution and role of the 4.1B protein in this organization. 4
Autor:
Katrin Deinhardt, Jeff Dupree, Yanqing Zhang, Enric Domènech-Estévez, Xiaosong Meng, Hasna Baloui, Roman Chrast, Steven Einheber, James L. Salzer
The signaling pathways that regulate myelination in the PNS remain poorly understood. Phosphatidylinositol-4,5-bisphosphate 3-kinase 1A, activated in Schwann cells by neuregulin and the extracellular matrix, has an essential role in the early events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090aa705c3727965015244e3d6833639
https://eprints.soton.ac.uk/390807/
https://eprints.soton.ac.uk/390807/
Autor:
James L. Salzer, Ambika Tewari, Ellen M. Leitman, Meryl E Horn, Carmen V. Melendez-Vasquez, Primal de Lanerolle, Evangelos Damanakis, Mateusz Urbanski, Steven Einheber
Publikováno v:
Journal of Cell Science. 124:3784-3796
Signaling through cyclic AMP (cAMP) has been implicated in the regulation of Schwann cell (SC) proliferation and differentiation. In quiescent SCs, elevation of cAMP promotes the expression of proteins associated with myelination such as Krox-20 and
Publikováno v:
Journal of Neuroscience Research. 89:310-319
The polarized domains of myelinated axons are specifically organized to maximize the efficiency of saltatory conduction. The paranodal region is directly adjacent to the node of Ranvier and contains specialized septate-like junctions that provide adh
Autor:
Steven S. Scherer, David H. Gutmann, Marina Rubin, Steven Einheber, James L. Salzer, Jolanta Galinska, Patrice Maurel, Pratik Thaker, Isabel Lam, Yoshinuri Murakami
Publikováno v:
The Journal of Cell Biology
Axon–glial interactions are critical for the induction of myelination and the domain organization of myelinated fibers. Although molecular complexes that mediate these interactions in the nodal region are known, their counterparts along the interno
Autor:
Gareth R. John, Cedric S. Raine, Carla Taveggia, Yueting Zhang, Steven Einheber, James L. Salzer, Celia F. Brosnan, Carmen V. Melendez-Vasquez
Publikováno v:
The Journal of Neuroscience. 26:12174-12185
Mechanisms that regulate oligodendrocyte survival and myelin formation are an intense focus of research into myelin repair in the lesions of multiple sclerosis (MS). Although demyelination and oligodendrocyte loss are pathological hallmarks of the di
Autor:
Gregory Dolganov, Dezhi Mu, Rodney Collins, Jun Araya, Stephanie E. Gline, Nancy Boudreau, Stephen L. Nishimura, Stephanie Cambier, Steven Einheber
Publikováno v:
The American Journal of Pathology. 166:1883-1894
Brain hemorrhage is a severe complication of both neoplastic and nonneoplastic brain disease. Mice deficient in the αvβ8 integrin display defective brain vessel formation resulting in hemorrhage and perinatal death, but the mechanism of brain hemor
Publikováno v:
Experimental Neurology. 179:200-209
The hippocampal formation is a brain region sensitive to seizure development, a phenomenon thought to be mediated in part by μ-opioid receptor (MOR) activation. Previous studies have found a delayed increase in MOR immunoreactivity (IR) in the inner
Autor:
James L. Salzer, George Zanazzi, Mark A. Marchionni, Melanie-Jane Hannocks, Steven Einheber, Richard Westreich, Debra Bedell-Hogan
Publikováno v:
The Journal of Cell Biology
During development, neuregulin-1 promotes Schwann cell proliferation and survival; its role in later events of Schwann cell differentiation, including myelination, is poorly understood. Accordingly, we have examined the effects of neuregulin-1 on mye