Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Steven Edward Lenicek"'
Autor:
Ronald C. Bernotas, Guo Ming Zhang, Lee E. Schechter, Schuyler Adam Antane, Steven Edward Lenicek, Deborah L. Smith, Boyd L. Harrison, Simon Haydar, Joseph Coupet, Albert J. Robichaud
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6935-6938
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which 6f and 6g showed high affinity for 5-HT6 receptors with Ki = 3.9 and 1.7 nM, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa35da68335dd080eacffafc9ecca94
https://doi.org/10.1016/j.bmcl.2009.10.067
https://doi.org/10.1016/j.bmcl.2009.10.067
Autor:
Deborah L. Smith, Lee E. Schechter, Michael Z. Kagan, Nicole T. Hatzenbuhler, Amedeo Arturo Failli, Deborah Ann Evrard, Zhang Minsheng, Jeannette Golembieski, Richard Eric Mewshaw, Margaret Lai, Steven Edward Lenicek, Michael Chlenov, Jean Sze, Terrance H. Andree, Dahui Zhou, Annmarie L. Saab, Geoffrey Hornby, Reinhardt Bernhard Baudy, Boyd L. Harrison, Uresh Shantilal Shah, Kelly Sullivan
Publikováno v:
Journal of Medicinal Chemistry. 51:6980-7004
Novel compounds combining a 5-HT 1A moiety (3-aminochroman scaffold) and a 5-HT transporter (indole analogues) linked through a common basic nitrogen via an alkyl chain attached at the 1- or 3-position of the indole were evaluated for dual affinity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0888e59808afb3d9088f68290cf3d60e
https://doi.org/10.1021/jm8007097
https://doi.org/10.1021/jm8007097
Autor:
Ronald C. Bernotas, Ping Li, Guo Ming Zhang, Deborah L. Smith, Lee E. Schechter, Boyd L. Harrison, Qian Lin, Derek C. Cole, Schuyler Adam Antane, Chad E. Beyer, Joseph Coupet, Albert J. Robichaud, Brian J. Platt, Steven Edward Lenicek, Sharon Rosenzweig-Lipson
Publikováno v:
Bioorganicmedicinal chemistry. 17(14)
A series of 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines 10a–z was prepared as novel 5-HT6 ligands. The best compounds were high affinity, full agonists at 5-HT6 receptors. Several agonists demonstrated good selectivity over other seroton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76955d2e7f3779550afa42e70ab53051
https://pubmed.ncbi.nlm.nih.gov/19523834
https://pubmed.ncbi.nlm.nih.gov/19523834
Autor:
Ronald C. Bernotas, Joseph Coupet, Guo Ming Zhang, Boyd L. Harrison, Schuyler Adam Antane, Steven Edward Lenicek, Deborah L. Smith, Lee E. Schechter
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(22)
Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1 H -indoles were prepared. Binding assays indicated they are 5-HT 6 receptor ligands, among which N , N -dimethyl- N -{2-[3-(1-naphthylsulfonyl)-1 H -indol-1-yl]ethyl}amine 8t and N -methyl- N -{2-[3-(1-naphth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6f8f13fb0292bed3e89231b544c60c
https://pubmed.ncbi.nlm.nih.gov/15482912
https://pubmed.ncbi.nlm.nih.gov/15482912