Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Steven E. Quatela"'
2
Cytosolic Ras Supports Eye Development in Drosophila
Autor: Aloma B. Rodrigues, Pamela J. Sung, Erika A. Bach, Steven E. Quatela, Andrew Kleinberger, Mark R. Philips
Publikováno v: Molecular and Cellular Biology. 30:5649-5657
Ras proteins regulate numerous cellular processes, including growth and differentiation. Mutations in Ras genes are associated with human cancer more frequently than those of any other oncogene. Ras is the founding member of a class of proteins known
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab870702cba597171480bd244983d4e8
https://doi.org/10.1128/mcb.00635-10
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3
Sprouty Proteins Inhibit Receptor-mediated Activation of Phosphatidylinositol-specific Phospholipase C
Autor: Charuta Ambardekar, Simge Akbulut, Barbara Canciani, Steven E. Quatela, Priya Aggarwal, Mark Phillips, Alagarsamy Lakku Reddi, Tomas Vilimas, Jacqueline M. Mason, M. Albert Basson, Samuel L. Collins, Jonathan D. Licht, Jonathan D. Powell, Matthew Lovatt, Laura M. Hix, Marianne K.H. Kim
Publikováno v: Molecular Biology of the Cell
PLCγ03B3 binds Spry1 and Spry2. Overexpression of Spry decreased PLCγ03B3 activity and IP3 and DAG production, whereas Spry-deficient cells yielded more IP3. Spry overexpression inhibited T-cell receptor signaling and Spry1 null T-cells hyperprolif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdaeac129bf8099dce9425f92ace9be6
https://doi.org/10.1091/mbc.e10-02-0123
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4
Activated Kras, but Not Hras or Nras, May Initiate Tumors of Endodermal Origin via Stem Cell Expansion
Autor: Jeffrey Settleman, Mark R. Philips, Margaret P. Quinlan, Steven E. Quatela
Publikováno v: Molecular and Cellular Biology. 28:2659-2674
The three closely related human Ras genes, Hras, Nras, and Kras, are all widely expressed, engage a common set of downstream effectors, and can each exhibit oncogenic activity. However, the vast majority of activating Ras mutations in human tumors in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f90a529a52ef29041ec78e88c6f0b1
https://doi.org/10.1128/mcb.01661-07
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5
Agpat6—a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium
Autor: Mark R. Philips, Rosemary L. Walzem, Stephen G. Young, Karen Reue, Steven E. Quatela, Xin Qiao, Steven M. Watkins, Rosalind A. Coleman, Ryan Davis, Anne P. Beigneux, Laurent Vergnes
Publikováno v: Journal of Lipid Research, Vol 47, Iss 4, Pp 734-744 (2006)
In analyzing the sequence tags for mutant mouse embryonic stem (ES) cell lines in BayGenomics (a mouse gene-trapping resource), we identified a novel gene, 1-acylglycerol-3-phosphate O-acyltransferase (Agpat6), with sequence similarities to previousl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b0cb3d2d152121a41f9798d61d34cd
https://doi.org/10.1194/jlr.m500556-jlr200
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6
PKC Regulates a Farnesyl-Electrostatic Switch on K-Ras that Promotes its Association with Bcl-Xl on Mitochondria and Induces Apoptosis
Autor: Adam Mor, Ignacio Pérez de Castro, Chi Li, Brian O. Bodemann, Michael J. Soskis, Adrienne D. Cox, Shahryar G Saba, Duke Yim, John Miura, Ian M. Ahearn, Adam Fein, Trever G. Bivona, Mark R. Philips, Steven E. Quatela, Latasha Wright, Heidi H. Wiener, Craig B. Thompson
Publikováno v: Molecular Cell. 21:481-493
K-Ras associates with the plasma membrane (PM) through farnesylation that functions in conjunction with an adjacent polybasic sequence. We show that phosphorylation by protein kinase C (PKC) of S181 within the polybasic region promotes rapid dissocia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4062d8fb7cbc60779deffbc5253ed6c4
https://doi.org/10.1016/j.molcel.2006.01.012
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7
Analysis of K‐Ras Phosphorylation, Translocation, and Induction of Apoptosis
Autor: Mark R. Philips, Steven E. Quatela, Ian M. Ahearn, Trever G. Bivona, Pamela J. Sung
Publikováno v: Methods in Enzymology ISBN: 9780123743114
K-Ras is a member of a family of proteins that associate with the plasma membrane by virtue of a lipid modification that inserts into the membrane and a polybasic region that associates with the anionic head groups of inner leaflet phospholipids. In
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a42a36166afff300272c7fa35a111aea
https://doi.org/10.1016/s0076-6879(07)00407-7
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9
Ras signaling on the Golgi
Autor: Mark R. Philips, Steven E. Quatela
Publikováno v: Current opinion in cell biology. 18(2)
The discovery that Ras proteins are modified by enzymes restricted to the endoplasmic reticulum and Golgi apparatus and that, at steady state, a significant pool of Ras is localized on the Golgi has led to the hypothesis that Ras can become activated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e677656e9bb81bda09048ef03eb20c4
https://pubmed.ncbi.nlm.nih.gov/16488589
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10
Analysis of Ras Activation in Living Cells with GFP‐RBD
Autor: Mark R. Philips, Trever G. Bivona, Steven E. Quatela
Several genetically encoded fluorescent biosensors for Ras family GTPases have been developed that permit spatiotemporal analysis of the activation of these signaling molecules in living cells. We describe here the use of the simplest of these probes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35510081c69a1095798197c686f21358
https://doi.org/10.1016/s0076-6879(05)07012-6
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