Parkinson's disease genetic risk in a midbrain neuronal cell line

Autor: Steven E. Pierce, Trevor Tyson, Alix Booms, Jordan Prahl, Gerhard A. Coetzee

Publikováno v: Neurobiology of Disease, Vol 114, Iss , Pp 53-64 (2018)

In genome-wide association studies of complex diseases, many risk polymorphisms are found to lie in non-coding DNA and likely confer risk through allele-dependent differences in gene regulatory elements. However, because distal regulatory elements ca

Externí odkaz: https://doaj.org/article/6a2cfec1199e409b94f45885fbc4ba2d

DNA strand asymmetry generated by CpG hemimethylation has opposing effects on CTCF binding

Autor: Stacey L Thomas, Ting-Hai Xu, Brittany L Carpenter, Steven E Pierce, Bradley M Dickson, Minmin Liu, Gangning Liang, Peter A Jones

Publikováno v: Nucleic Acids Research.

CpG methylation generally occurs on both DNA strands and is essential for mammalian development and differentiation. Until recently, hemimethylation, in which only one strand is methylated, was considered to be simply a transitory state generated dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bd48d1507345ac16b8d6e7aee2b95f7
https://doi.org/10.1093/nar/gkad293

Alpha-synuclein negatively controls cell proliferation in dopaminergic neurons

Autor: Jordan Prahl, Steven E. Pierce, Gerhard A. Coetzee, Trevor Tyson

Publikováno v: Molecular and cellular neurosciences. 119

As researchers grapple with the mechanisms and implications of alpha-synuclein (α-syn) in neuropathology, it is often forgotten that the function(s) of α-syn in healthy cells remain largely elusive. Previous work has relied on observing α-syn loca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc2479615cc15a98fa29f5a674aa8b0
https://pubmed.ncbi.nlm.nih.gov/35093507

Parkinson’s Disease Genetic Risk Evaluation in Microglia Highlights Autophagy and Lysosomal Genes

Autor: Steven E. Pierce, Gerhard A. Coetzee, Alix Booms

Genome-wide association studies (GWAS) have uncovered thousands of single nucleotide polymorphisms (SNPs) that are associated with Parkinson’s disease (PD) risk. The functions of most of these SNPs, including the cell type they influence, and how t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f66e5dfbc4566bcb5686ad07ad938e3f
https://doi.org/10.1101/2020.08.17.254276

Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

Autor: Emily Schulz, Lena Brundin, Martha L. Escobar Galvis, Nolwen L. Rey, Trevor A. Tyson, Zachary Madaj, Patrik Brundin, Sonia George, Corinne Esquibel, Steven E. Pierce, Amanda R. Burmeister, Jennifer A. Steiner, Lindsay Meyerdirk

Publikováno v: Molecular Neurodegeneration
Molecular Neurodegeneration, BioMed Central, 2019, 14, pp.34. ⟨10.1186/s13024-019-0335-3⟩
Molecular Neurodegeneration, 2019, 14, pp.34. ⟨10.1186/s13024-019-0335-3⟩
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-22 (2019)

Background Cell-to-cell propagation of α-synuclein (α-syn) aggregates is thought to contribute to the pathogenesis of Parkinson’s disease (PD) and underlie the spread of α-syn neuropathology. Increased pro-inflammatory cytokine levels and activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef1a46d6df331dd021eac255c0d5d56
http://europepmc.org/articles/PMC6697982