Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Steven E. Cwirla"'
Autor:
William J Dower, Angie Inkyung Park, Alice V Bakker, Steven E Cwirla, Praechompoo Pongtornpipat, Blake M Williams, Prarthana Joshi, Bryan A Baxter, Michael C Needels, Ronald W Barrett
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0286834 (2023)
Interleukin (IL)-7 is broadly active on T-cell populations, and modified versions have been clinically evaluated for a variety of therapeutic applications, including cancer, lymphopenia, and infectious diseases; and found to be relatively well-tolera
Externí odkaz:
https://doaj.org/article/3bd59ccdb97e4f0fb8a0e9145823542e
Autor:
William J. Dower, Angie Inkyung Park, Alice V. Bakker, Steven E. Cwirla, Praechompoo Pongtornpipat, Blake M. Williams, Prarthana Joshi, Bryan A. Baxter, Michael C. Needels, Ronald W. Barrett
Interleukin (IL)-7 is broadly active on T-cell populations, and modified versions have been clinically evaluated for a variety of therapeutic applications, including cancer, lymphopenia and infectious diseases; and found to be relatively well-tolerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ff65917a24a1a813fbc673b68412542
https://doi.org/10.1101/2023.05.24.542196
https://doi.org/10.1101/2023.05.24.542196
Autor:
William J. Dower, Steven E. Cwirla, Bakker Alice, Prarthana Joshi, Ronald W. Barrett, Michael C. Needels, Praechompoo Pongtornpipat, Blake Williams
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundRecent reports demonstrate that directing a “non-alpha” IL-2 mutant to a PD-1high CD8+ stem-like population induces proliferation, and differentiation into a highly functional cytotoxic phenotype. We previously reported small synthetic
Autor:
Angie I. Park, Steven E. Cwirla, Alice V. Bakker, Blake M. Williams, Prarthana Joshi, Praechompoo Pongtornpipat, Sandra M. Wang, Bryan Baxter, Michael C. Needels, Ronald W. Barrett, William J. Dower
Publikováno v:
Cancer Research. 82:2066-2066
Background: IL-7 receptor activation is essential for the proper development and homeostasis of T-cell subpopulations, and maintenance of the TCR clonal repertoire. Emerging evidence indicates potential clinical utility of IL-7 for immunotherapy of l
Autor:
Ronald W. Barrett, Bakker Alice, Praechompoo Pongtornpipat, Blake Williams, Michael C. Needels, Steven E. Cwirla, Prarthana Joshi, William J. Dower, Sandra Wang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background IL-7 receptor activation is essential for the proper development and homeostasis of T-cell subpopulations, and maintenance of the TCR clonal repertoire. Emerging evidence indicates potential clinical utility of IL-7 for immunotherapy of ly
Autor:
Sandra Wang, Bakker Alice, Steven E. Cwirla, Praechompoo Pongtornpipat, Ronald W. Barrett, Blake Williams, Michael C. Needels, William J. Dower, Prarthana Joshi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Efforts to modify IL-2 for immuno-oncology applications focus on modifying the receptor selectivity of IL-2 to bias effects on immune cells; in particular, to reduce Rα interaction via mutation, chemical modification, complexation with an
Autor:
Ronald W. Barrett, Steven E. Cwirla, Michael C. Needels, Prarthana Joshi, William J. Dower, Sandra Wang, Praechompoo Pongtornpipat, Bakker Alice, Blake Williams
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Activation of IL-2/15Rβγc or IL-7R on immune cells using modified versions of IL-2 or IL-7 is under investigation as monotherapy, or in combination with checkpoint inhibitors, engineered T or NK cells, or neo-antigen vaccines. We previou
Autor:
Steven E. Cwirla, Palaniappan Balasubramanian, Ronald W. Barrett, Nicholas C. Wrighton, Peter J. Schatz, Wagstrom Christopher R, Duffin David J, David P. Baccanari, Robert L. Tansik, Sara C. Singer, Ann M. Davis, Chris M. Boytos, Christian M. Gates, William J. Dower, Larry C. Mattheakis
Publikováno v:
Science. 276:1696-1699
Two families of small peptides that bind to the human thrombopoietin receptor and compete with the binding of the natural ligand thrombopoietin (TPO) were identified from recombinant peptide libraries. The sequences of these peptides were not found i
Autor:
Ronald W. Barrett, Erik A. Whitehorn, Jason P. Chinn, John H. Butler, Steven E. Cwirla, Ann L. Akeson, Frank Holden, Palaniappan Balasubramanian, William J. Dower, Jeffrey W. Jacobs, Elizabeth Peters-Bhatt, David N. Baldwin, Terry L. Bowlin, Emily Tate, Stephen Yanofsky
Publikováno v:
Proceedings of the National Academy of Sciences. 93:7381-7386
Two families of peptides that specifically bind the extracellular domain of the human type I interleukin I (IL-1) receptor were identified from recombinant peptide display libraries. Peptides from one of these families blocked binding of IL-lalpha to
Autor:
Christine L. Martens, Steven E. Cwirla, Rozanne Y.-W. Lee, Erik Whitehorn, Esther Y.-F. Chen, Alice Bakker, Edith L. Martin, Christopher Wagstrom, Priya Gopalan, C. Wayne Smith, Emily Tate, Kerry J. Koller, Peter J. Schatz, William J. Dower, Ronald W. Barrett
Publikováno v:
Journal of Biological Chemistry. 270:21129-21136
E-selectin is an inducible cell adhesion molecule which mediates rolling of neutrophils on the endothelium, an early event in the development of an inflammatory response. Inhibition of selectin-mediated rolling is a possible means for controlling inf