Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Steven E Bosinger"'
Autor:
Cordelia Manickam, Amit A Upadhyay, Griffin Woolley, Kyle W Kroll, Karen Terry, Courtney A Broedlow, Nichole R Klatt, Steven E Bosinger, R Keith Reeves
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012223 (2024)
Natural killer-like B (NKB) cells are unique innate immune cells expressing both natural killer (NK) and B cell receptors. As first responders to infection, they secrete IL-18 to induce a critical cascade of innate and adaptive immune cell infiltrati
Externí odkaz:
https://doaj.org/article/66bb7e6cf16643e8817768d7427341ee
Autor:
Rohini Mopuri, Sarah Welbourn, Tysheena Charles, Pooja Ralli-Jain, David Rosales, Samantha Burton, Areeb Aftab, Kirti Karunakaran, Kathryn Pellegrini, William Kilembe, Etienne Karita, Sandrasegaram Gnanakaran, Amit A Upadhyay, Steven E Bosinger, Cynthia A Derdeyn
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011717 (2023)
A protective HIV-1 vaccine has been hampered by a limited understanding of how B cells acquire neutralizing activity. Our previous vaccines expressing two different HIV-1 envelopes elicited robust antigen specific serum IgG titers in 20 rhesus macaqu
Externí odkaz:
https://doaj.org/article/1134d83f0e044f18b5105af8a940f58d
Autor:
Sarah J Byrnes, Kathleen Busman-Sahay, Thomas A Angelovich, Skyler Younger, Sol Taylor-Brill, Michael Nekorchuk, Stephen Bondoc, Rachel Dannay, Margaret Terry, Catherine R Cochrane, Trisha A Jenkins, Michael Roche, Claire Deleage, Steven E Bosinger, Mirko Paiardini, Bruce J Brew, Jacob D Estes, Melissa J Churchill
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011290 (2023)
HIV-associated neurocognitive disorders (HAND) affect ~40% of virally suppressed people with HIV (PWH), however, the precise viral dependent and independent changes to the brain are unclear. Here we characterized the CNS reservoir and immune environm
Externí odkaz:
https://doaj.org/article/a8b2d780e7df44039d495cd700b5e282
Autor:
Zachary Strongin, Timothy N Hoang, Gregory K Tharp, Andrew R Rahmberg, Justin L Harper, Kevin Nguyen, Lavinia Franchitti, Barbara Cervasi, Max Lee, Zhan Zhang, Eli A Boritz, Guido Silvestri, Vincent C Marconi, Steven E Bosinger, Jason M Brenchley, Deanna A Kulpa, Mirko Paiardini
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010723 (2022)
Despite the advent of effective antiretroviral therapy (ART), human immunodeficiency virus (HIV) continues to pose major challenges, with extensive pathogenesis during acute and chronic infection prior to ART initiation and continued persistence in a
Externí odkaz:
https://doaj.org/article/0d173f19d60843dc8264274e0962880c
Autor:
Sarah Welbourn, Srirupa Chakraborty, Jie E Yang, Anne S Gleinich, Sailaja Gangadhara, Salar Khan, Courtney Ferrebee, Bhrugu Yagnik, Samantha Burton, Tysheena Charles, S Abigail Smith, Danielle Williams, Rohini Mopuri, Amit A Upadhyay, Justin Thompson, Matt A Price, Shiyu Wang, Zhaohui Qin, Xiaoying Shen, LaTonya D Williams, Nathan Eisel, Tiffany Peters, Lu Zhang, William Kilembe, Etienne Karita, Georgia D Tomaras, Steven E Bosinger, Rama R Amara, Parastoo Azadi, Elizabeth R Wright, Sandrasegaram Gnanakaran, Cynthia A Derdeyn
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010488 (2022)
Transmitted/founder (T/F) HIV-1 envelope proteins (Envs) from infected individuals that developed neutralization breadth are likely to possess inherent features desirable for vaccine immunogen design. To explore this premise, we conducted an immuniza
Externí odkaz:
https://doaj.org/article/57b66c8bac8a49fbb543e6148e785893
Autor:
Jacqueline Corry, Gwenddolen Kettenburg, Amit A Upadhyay, Megan Wallace, Michelle M Marti, Elizabeth R Wonderlich, Stephanie J Bissel, Kyndal Goss, Timothy J Sturgeon, Simon C Watkins, Douglas S Reed, Steven E Bosinger, Simon M Barratt-Boyes
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010395 (2022)
Severe influenza kills tens of thousands of individuals each year, yet the mechanisms driving lethality in humans are poorly understood. Here we used a unique translational model of lethal H5N1 influenza in cynomolgus macaques that utilizes inhalatio
Externí odkaz:
https://doaj.org/article/158a2ae8d6714870a76bb7c76eda7ece
Autor:
Michelle Y-H Lee, Amit A Upadhyay, Hasse Walum, Chi N Chan, Reem A Dawoud, Christine Grech, Justin L Harper, Kirti A Karunakaran, Sydney A Nelson, Ernestine A Mahar, Kyndal L Goss, Diane G Carnathan, Barbara Cervasi, Kiran Gill, Gregory K Tharp, Elizabeth R Wonderlich, Vijayakumar Velu, Simon M Barratt-Boyes, Mirko Paiardini, Guido Silvestri, Jacob D Estes, Steven E Bosinger
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009674 (2021)
HIV associated immune activation (IA) is associated with increased morbidity in people living with HIV (PLWH) on antiretroviral therapy, and remains a barrier for strategies aimed at reducing the HIV reservoir. The underlying mechanisms of IA have no
Externí odkaz:
https://doaj.org/article/23f45ec77beb4055b59259a74d913d13
Autor:
Radhakrishna Muttineni, Nagamani Kammili, Thrilok Chander Bingi, Raja Rao M, Kalyani Putty, Pankaj Singh Dholaniya, Ravi Kumar Puli, Sunitha Pakalapati, Saritha S, Shekar K, Mallikarjuna Reddy Doodipala, Amit A Upadhyay, Steven E Bosinger, Rama R Amara, Anand K Kondapi
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246173 (2021)
We report clinical profile of hundred and nine patients with SARS CoV-2 infection, and whole genome sequences (WGS) of seven virus isolates from the first reported cases in India, with various international travel histories. Comorbidities such as dia
Externí odkaz:
https://doaj.org/article/625c4fc214b547b98d6cb04fa3a06ba7
Autor:
Michelle Zanoni, David Palesch, Claudia Pinacchio, Maura Statzu, Gregory K Tharp, Mirko Paiardini, Ann Chahroudi, Steven E Bosinger, Jack Yoon, Bryan Cox, Guido Silvestri, Deanna A Kulpa
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008821 (2020)
MHC-I-restricted, virus-specific cytotoxic CD8+ T cells (CTLs) may control human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication via the recognition and killing of productively infected CD4+ T cells. Several studies i
Externí odkaz:
https://doaj.org/article/88b19171596b48d391661c9c882ff045
Autor:
Krystelle Nganou-Makamdop, James M Billingsley, Zachary Yaffe, Gregory O'Connor, Gregory K Tharp, Amy Ransier, Farida Laboune, Rodrigo Matus-Nicodemos, Andrea Lerner, Lavina Gharu, Jennifer M Robertson, Mandy L Ford, Martin Schlapschy, Nadine Kuhn, Alexandra Lensch, Jeffrey Lifson, Martha Nason, Arne Skerra, Gideon Schreiber, Steven E Bosinger, Daniel C Douek
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007246 (2018)
Chronic activation of the immune system in HIV infection is one of the strongest predictors of morbidity and mortality. As such, approaches that reduce immune activation have received considerable interest. Previously, we demonstrated that administra
Externí odkaz:
https://doaj.org/article/222e9d607de04416ad02ccb59781e2f1