Zobrazeno 1 - 10
of 512
pro vyhledávání: '"Steven E Arnold"'
Autor:
Ruth Luthi-Carter, Sara Cappelli, Morgan Le Roux-Bourdieu, Noemie Tentillier, James P. Quinn, Tiziana Petrozziello, Lathika Gopalakrishnan, Purva Sethi, Himanshi Choudhary, Giorgia Bartolini, Elias Gebara, Cristiana Stuani, Laure Font, Jiyan An, Vanessa Ortega, Jessica Sage, Edina Kosa, Bianca A. Trombetta, Roberto Simeone, Tamara Seredenina, Tariq Afroz, James D. Berry, Steven E. Arnold, Becky C. Carlyle, Oskar Adolfsson, Ghazaleh Sadri-Vakili, Emanuele Buratti, Robert Bowser, Abdulbaki Agbas
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The TAR DNA Binding Protein 43 (TDP-43) has been implicated in the pathogenesis of human neurodegenerative diseases and exhibits hallmark neuropathology in amyotrophic lateral sclerosis (ALS). Here, we explore its tractability as a plasma bi
Externí odkaz:
https://doaj.org/article/a0db3bccec97456caa51182a2870d211
Autor:
Bianca A Trombetta, Becky C Carlyle, Aaron M Koenig, Leslie M Shaw, John Q Trojanowski, David A Wolk, Joseph J Locascio, Steven E Arnold
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193707 (2018)
Alzheimer's disease (AD) is a complex neurodegenerative disease driven by multiple interacting pathophysiological processes that ultimately results in synaptic loss, neuronal death, and dementia. We implemented a fit-for-purpose modeled approach to q
Externí odkaz:
https://doaj.org/article/9f12bf63a7ef4310b58a6a0ca0f6d16e
Autor:
Han Tong, Ana W. Capuano, Rupal I. Mehta, Ajay Sood, David A. Bennett, Rexford S. Ahima, Steven E. Arnold, Zoe Arvanitakis
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 8, Pp 2112-2122 (2024)
Abstract Objective To examine the associations of renin–angiotensin system (RAS) inhibitor use with postmortem brain insulin signaling and neuropathology. Methods Among Religious Orders Study participants, 150 deceased and autopsied older individua
Externí odkaz:
https://doaj.org/article/7557244e39174b8fabf06adc744b5a05
Autor:
Dean Ornish, Catherine Madison, Miia Kivipelto, Colleen Kemp, Charles E. McCulloch, Douglas Galasko, Jon Artz, Dorene Rentz, Jue Lin, Kim Norman, Anne Ornish, Sarah Tranter, Nancy DeLamarter, Noel Wingers, Carra Richling, Rima Kaddurah-Daouk, Rob Knight, Daniel McDonald, Lucas Patel, Eric Verdin, Rudolph E. Tanzi, Steven E. Arnold
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Evidence links lifestyle factors with Alzheimer’s disease (AD). We report the first randomized, controlled clinical trial to determine if intensive lifestyle changes may beneficially affect the progression of mild cognitive impa
Externí odkaz:
https://doaj.org/article/88f3200bfb0542db8b347084c5b976dd
Autor:
Lauren Breithaupt, Laura M. Holsen, Chunni Ji, Jie Hu, Felicia Petterway, Megan Rosa-Caldwell, Ida A.K. Nilsson, Jennifer J. Thomas, Kyle A. Williams, Regine Boutin, Meghan Slattery, Cynthia M. Bulik, Steven E. Arnold, Elizabeth A. Lawson, Madhusmita Misra, Kamryn T. Eddy
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 5, Pp 100332- (2024)
Background: Proteomics offers potential for detecting and monitoring anorexia nervosa (AN) and its variant, atypical AN (atyp-AN). However, research has been limited by small protein panels, a focus on adult AN, and lack of replication. Methods: In t
Externí odkaz:
https://doaj.org/article/5e8ec272db2e4c6dbf96303e4cff090a
Publikováno v:
SAGE Open Medicine, Vol 4 (2016)
Objective: The Latino/Hispanic community in the United States is at higher risk of developing Alzheimer’s disease than other ethnic groups. Specifically, Caribbean Hispanics showed a more severe Alzheimer’s disease symptomatology than any other e
Externí odkaz:
https://doaj.org/article/6af35cd2396e42efbbe31dffdf9f1e89
Autor:
Simon J. Pelletier, Mickaël Leclercq, Florence Roux-Dalvai, Matthijs B. de Geus, Shannon Leslie, Weiwei Wang, TuKiet T. Lam, Angus C. Nairn, Steven E. Arnold, Becky C. Carlyle, Frédéric Precioso, Arnaud Droit
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Liquid Chromatography Mass Spectrometry (LC-MS) is a powerful method for profiling complex biological samples. However, batch effects typically arise from differences in sample processing protocols, experimental conditions, and data acquisit
Externí odkaz:
https://doaj.org/article/f411488984d94091a9e476c56116f06f
Autor:
Mahesh Chandra Kodali, Jerry Antone, Eric Alsop, Rojashree Jayakumar, Khushi Parikh, Aude Chiot, Paula Sanchez-Molina, Bahareh Ajami, Steven E. Arnold, Kendall Jensen, Sudeshna Das, Marc S. Weinberg
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract Cerebrospinal fluid (CSF) matrix biomarkers have become increasingly valuable surrogate markers of neuropsychiatric diseases in research and clinical practice. In contrast, CSF cells have been rarely investigated due to their relative scarci
Externí odkaz:
https://doaj.org/article/e8d2d891434e4ed1ae5ac3f2d46be021
Publikováno v:
Frontiers in Aging Neuroscience, Vol 5 (2013)
Episodic memory loss is the hallmark cognitive dysfunction associated with Alzheimer’s Disease (AD). Amnestic Mild Cognitive Impairment (a-MCI) frequently represents a transitional stage between normal aging and early AD. A better understanding of
Externí odkaz:
https://doaj.org/article/8f17b10489904f9ba982c7ded1765fff
Autor:
Steven E. Arnold, Suzanne Hendrix, Jessie Nicodemus‐Johnson, Newman Knowlton, Victoria J. Williams, Jeffrey M. Burns, Monica Crane, Alison J. McManus, Sanjeev N. Vaishnavi, Zoe Arvanitakis, Judith Neugroschl, Karen Bell, Bianca A. Trombetta, Becky C. Carlyle, Pia Kivisäkk, Hiroko H. Dodge, Rudolph E. Tanzi, Patrick D. Yeramian, Kent Leslie
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 3, Pp n/a-n/a (2024)
Abstract INTRODUCTION Sodium phenylbutyrate and taurursodiol (PB and TURSO) is hypothesized to mitigate endoplasmic reticulum stress and mitochondrial dysfunction, two of many mechanisms implicated in Alzheimer's disease (AD) pathophysiology. METHODS
Externí odkaz:
https://doaj.org/article/094dc11770e44f12a0e5cddf65670bfc