Zobrazeno 1 - 10 of 84 pro vyhledávání: '"Steven E, Mutsaers"'
1
Akademický článek
The contribution of animal models to understanding the role of the immune system in human idiopathic pulmonary fibrosis
Autor: Tylah Miles, Gerard F Hoyne, Darryl A Knight, Mark W Fear, Steven E Mutsaers, Cecilia M Prêle
Publikováno v: Clinical & Translational Immunology, Vol 9, Iss 7, Pp n/a-n/a (2020)
Abstract Pulmonary fibrosis occurs in a heterogeneous group of lung disorders and is characterised by an excessive deposition of extracellular matrix proteins within the pulmonary interstitium, leading to impaired gas transfer and a loss of lung func
Externí odkaz: https://doaj.org/article/c4411332b0ed47deac6487b7ba36ef37
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2
Akademický článek
A Senescence Bystander Effect in Human Lung Fibroblasts
Autor: David W. Waters, Michael Schuliga, Prabuddha S. Pathinayake, Lan Wei, Hui-Ying Tan, Kaj E. C. Blokland, Jade Jaffar, Glen P. Westall, Janette K. Burgess, Cecilia M. Prêle, Steven E. Mutsaers, Christopher L. Grainge, Darryl A. Knight
Publikováno v: Biomedicines, Vol 9, Iss 9, p 1162 (2021)
Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterised by a dense fibrosing of the lung parenchyma. An association between IPF and cellular senescence is well established and several studies now describe a higher abundance of senescen
Externí odkaz: https://doaj.org/article/9b887b3e6a684a2cbaf59851201b3ebd
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3
Akademický článek
Reduced SOCS1 Expression in Lung Fibroblasts from Patients with IPF Is Not Mediated by Promoter Methylation or Mir155
Autor: Cecilia M. Prêle, Thomas Iosifidis, Robin J. McAnulty, David R. Pearce, Bahareh Badrian, Tylah Miles, Sarra E. Jamieson, Matthias Ernst, Philip J. Thompson, Geoffrey J. Laurent, Darryl A. Knight, Steven E. Mutsaers
Publikováno v: Biomedicines, Vol 9, Iss 5, p 498 (2021)
The interleukin (IL)-6 family of cytokines and exaggerated signal transducer and activator of transcription (STAT)3 signaling is implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis, but the mechanisms regulating STAT3 expression and functi
Externí odkaz: https://doaj.org/article/f48fa198e8004c7484e59b7e0c37a1fd
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4
Akademický článek
Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing
Autor: Kaj E. C. Blokland, David W. Waters, Michael Schuliga, Jane Read, Simon D. Pouwels, Christopher L. Grainge, Jade Jaffar, Glen Westall, Steven E. Mutsaers, Cecilia M. Prêle, Janette K. Burgess, Darryl A. Knight
Publikováno v: Pharmaceutics, Vol 12, Iss 4, p 389 (2020)
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease marked by excessive accumulation of lung fibroblasts (LFs) and collagen in the lung parenchyma. The mechanisms that underlie IPF pathophysiology are thought to reflect repeated alveola
Externí odkaz: https://doaj.org/article/c78d3268b80d43e7a397a1b9abe04195
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6
A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: A potential drug target in IPF
Autor: Cecilia M. Prêle, Claire Thomson, Darryl A. Knight, Steven E. Mutsaers, Amama Kanwal, Kaj E C Blokland, Jane Read, Michael Schuliga, Janette K. Burgess, Christopher Grainge, Nathan W. Bartlett, Allen James
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology, 321(5), L859-L871. AMER PHYSIOLOGICAL SOC
Alveolar epithelial cell (AEC) senescence is implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Mitochondrial dysfunction including release of mitochondrial DNA (mtDNA) is a feature of senescence, which led us to investigate the r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c5aa3b2b498def3fbda3c8f9e1ee71
https://research.rug.nl/en/publications/556d48b1-48e1-4762-9dc7-e55a4f14cabd
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7
STAT3 Regulates the Onset of Oxidant-induced Senescence in Lung Fibroblasts
Autor: Lan Wei, Steven E. Mutsaers, Christopher Grainge, Jade Jaffar, Michael Schuliga, Prabuddha S. Pathinayake, Janette K. Burgess, Glen P. Westall, Philip M. Hansbro, Darryl A. Knight, Kaj E C Blokland, Nathan W. Bartlett, Cecilia M. Prêle, David W Waters
Publikováno v: American Journal of Respiratory Cell and Molecular Biology, 61(1), 61-73. AMER THORACIC SOC
American Journal of Respiratory Cell and Molecular Biology
Copyright © 2019 by the American Thoracic Society. Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of unknown cause with a median survival of only 3 years. Other investigators and we have shown that fibroblasts derived from IPF lungs d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848e0235d134b3996913761b4bbfccac
https://research.rug.nl/en/publications/e147dfea-db16-4264-9ee4-99109337ae60
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8
Plasma cell but not CD20-mediated B-cell depletion protects from bleomycin-induced lung fibrosis
Autor: Cecilia M. Prêle, Tylah Miles, David R. Pearce, Robert J. O'Donoghue, Chris Grainge, Lucy Barrett, Kimberly Birnie, Andrew D. Lucas, Svetlana Baltic, Matthias Ernst, Catherine Rinaldi, Geoffrey J. Laurent, Darryl A. Knight, Mark Fear, Gerard Hoyne, Robin J. McAnulty, Steven E. Mutsaers
Publikováno v: European Respiratory Journal. 60:2101469
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease associated with chronic inflammation and tissue remodelling leading to fibrosis, reduced pulmonary function, respiratory failure and death. Bleomycin (Blm)-induced lung fibrosis in m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0379165739a949815746194e682651
https://doi.org/10.1183/13993003.01469-2021
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9
Reduced SOCS1 Expression in Lung Fibroblasts from Patients with IPF Is Not Mediated by Promoter Methylation or Mir155
Autor: Geoffrey J. Laurent, Philip J. Thompson, David R. Pearce, Sarra E. Jamieson, Matthias Ernst, Tylah Miles, Cecilia M Prêle, Robin J. McAnulty, Darryl A. Knight, Bahareh Badrian, Steven E. Mutsaers, Thomas Iosifidis
Publikováno v: Biomedicines, Vol 9, Iss 498, p 498 (2021)
Biomedicines
Volume 9
Issue 5
The interleukin (IL)-6 family of cytokines and exaggerated signal transducer and activator of transcription (STAT)3 signaling is implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis, but the mechanisms regulating STAT3 expression and functi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cda7d3b343c9dd9bd66e01e90ae55aa
https://www.mdpi.com/2227-9059/9/5/498
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10
Akademický článek
Mutational analysis of hedgehog signaling pathway genes in human malignant mesothelioma.
Autor: Chuan Bian Lim, Cecilia M Prêle, Hui Min Cheah, Yuen Yee Cheng, Sonja Klebe, Glen Reid, D Neil Watkins, Svetlana Baltic, Philip J Thompson, Steven E Mutsaers
Publikováno v: PLoS ONE, Vol 8, Iss 6, p e66685 (2013)
BACKGROUND: The Hedgehog (HH) signaling pathway is critical for embryonic development and adult homeostasis. Recent studies have identified regulatory roles for this pathway in certain cancers with mutations in the HH pathway genes. The extent to whi
Externí odkaz: https://doaj.org/article/8fb1acf1b01742ddb64b80e1669bc29c
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