Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Steven E, Kirberger"'
Autor:
Jeffrey Y. K. Wong, Arunika I. Ekanayake, Serhii Kharchenko, Steven E. Kirberger, Ryan Qiu, Payam Kelich, Susmita Sarkar, Jiaqian Li, Kleinberg X. Fernandez, Edgar R. Alvizo-Paez, Jiayuan Miao, Shiva Kalhor-Monfared, J. Dwyer John, Hongsuk Kang, Hwanho Choi, John M. Nuss, John C. Vederas, Yu-Shan Lin, Matthew S. Macauley, Lela Vukovic, William C. K. Pomerantz, Ratmir Derda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Peptide-based therapeutics have gained attention as promising therapeutic modalities, however, their prevalent drawback is poor circulation half-life in vivo. In this paper, we report the selection of albumin-binding macrocyclic peptides fro
Externí odkaz:
https://doaj.org/article/70cf58a7e9004f0fbc1e0c30b3084ed6
Autor:
Jeffrey Y. K. Wong, Arunika I. Ekanayake, Serhii Kharchenko, Steven E. Kirberger, Ryan Qiu, Payam Kelich, Susmita Sarkar, Jiaqian Li, Kleinberg X. Fernandez, Edgar R. Alvizo-Paez, Jiayuan Miao, Shiva Kalhor-Monfared, J. Dwyer John, Hongsuk Kang, Hwanho Choi, John M. Nuss, John C. Vederas, Yu-Shan Lin, Matthew S. Macauley, Lela Vukovic, William C. K. Pomerantz, Ratmir Derda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/71139748923945fe95b7a358e1ee3960
Autor:
Wesley D. Frey, Anisha Chaudhry, Priscila F. Slepicka, Adam M. Ouellette, Steven E. Kirberger, William C.K. Pomerantz, Gregory J. Hannon, Camila O. dos Santos
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 23-31 (2017)
Chromatin remodeling is a key requirement for transcriptional control of cellular differentiation. However, the factors that alter chromatin architecture in mammary stem cells (MaSCs) are poorly understood. Here, we show that BPTF, the largest subuni
Externí odkaz:
https://doaj.org/article/67eb2c4ce2b741fdab98f03d0c6842ac
Autor:
Jeffrey Y.K. Wong, Steven E. Kirberger, Ryan Qiu, Arunika I. Ekanayake, Payam Kelich, Susmita Sarkar, Edgar R. Alvizo-Paez, Jiayuan Miao, Shiva Kalhor-Monfared, John J. Dwyer, John M. Nuss, Yu-Shan Lin, Matthew S. Macauley, Lela Vukovic, William C.K. Pomerantz, Ratmir Derda
In this paper, we report selection of albumin-binding macrocyclic peptides from genetically encoded libraries of peptides modified by perfluoroaryl-cysteine SNAr chemistry. Modification of phage-displayed libraries SXCXnC-phage, n=3–5, where X is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::645659c7fda621bd66245957c6c95240
https://doi.org/10.1101/2022.08.22.504611
https://doi.org/10.1101/2022.08.22.504611
Autor:
Christos A. Nicolaou, Haitao Hu, Steven E. Kirberger, Anil K. Pandey, Jorden A. Johnson, William C. K. Pomerantz
Publikováno v:
ACS Med Chem Lett
[Image: see text] Fragment-based ligand discovery has been successful in targeting diverse proteins. Despite drug-like molecules having more 3D character, traditional fragment libraries are largely composed of flat, aromatic fragments. The use of 3D-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedc7d52f6534f7b8d0d71e6c82b7637
https://doi.org/10.1021/acsmedchemlett.9b00414
https://doi.org/10.1021/acsmedchemlett.9b00414
Publikováno v:
Accounts of Chemical Research. 52:3407-3418
Inhibitor discovery for protein-protein interactions has proven difficult due to the large protein surface areas and dynamic interfaces involved. This is particularly the case when targeting transcription-factor-protein interactions. To address this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c4d52f46328e9ce672f8b416f0c12fe
https://doi.org/10.1021/acs.accounts.9b00377
https://doi.org/10.1021/acs.accounts.9b00377
Autor:
Steven E. Kirberger, Adam M. Ouellette, Priscila Ferreira Slepicka, Wesley D. Frey, Anisha Chaudhry, Gregory J. Hannon, William C. K. Pomerantz, Camila O. dos Santos
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 23-31 (2017)
Stem Cell Reports
Stem Cell Reports
Summary Chromatin remodeling is a key requirement for transcriptional control of cellular differentiation. However, the factors that alter chromatin architecture in mammary stem cells (MaSCs) are poorly understood. Here, we show that BPTF, the larges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341cec7b87db6f617ca8dc77ec1b1eca
http://www.sciencedirect.com/science/article/pii/S2213671117301856
http://www.sciencedirect.com/science/article/pii/S2213671117301856
Autor:
Steven E. Kirberger, Michael Garwood, Samuel A. Einstein, Joseph C. Manulik, William C. K. Pomerantz, Bradley P. Weegman, Sofia D. Maltseva
Publikováno v:
Angewandte Chemie. 129:6540-6544
19F MRI is valuable for in vivo imaging due to the only trace amounts of fluorine in biological systems. Because of the low sensitivity of MRI however, designing new fluorochemicals remains a significant challenge for achieving sufficient 19F signal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00dedf003e8df79521f1cb985455fe0
https://doi.org/10.1002/ange.201700426
https://doi.org/10.1002/ange.201700426
Autor:
Jennifer R Kimbrough, Jorden A. Johnson, Steven E. Kirberger, Anil K. Pandey, William C. K. Pomerantz, Danika K. D. Partridge
Publikováno v:
Organic Letters. 22:5271-5272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::173819c7e978044c4ea4329af2e6d201
https://doi.org/10.1021/acs.orglett.0c01848
https://doi.org/10.1021/acs.orglett.0c01848
Autor:
Alex Dickson, Hideki Aihara, Mohammed Kashani-Sabet, Junwei Shi, Jorden A. Johnson, Steven E. Kirberger, Ke Shi, Michael F. Ciccone, Peter D. Ycas, Andrew K. Urick, William C. K. Pomerantz, Rinette Woo, Camila O. dos Santos, Sean D. McAllister, Huda Zahid, Chen Chen
Publikováno v:
Organicbiomolecular chemistry. 17(7)
Bromodomain and PHD finger containing protein transcription factor (BPTF) is an epigenetic protein involved in chromatin remodelling and is a potential anticancer target. The BPTF bromodomain has one reported small molecule inhibitor (AU1, rac-1). He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c15fc8e76d4e955d7c055f91cdea57a
https://pubmed.ncbi.nlm.nih.gov/30706071
https://pubmed.ncbi.nlm.nih.gov/30706071