Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Steven E, Jacobsen"'
Publikováno v:
eLife, Vol 12 (2024)
Silencing pathways prevent transposable element (TE) proliferation and help to maintain genome integrity through cell division. Silenced genomic regions can be classified as either euchromatic or heterochromatic, and are targeted by genetically separ
Externí odkaz:
https://doaj.org/article/f173910d7dd743d1b0e8d98004df95ca
Autor:
Zhen Wang, Claudia M. Castillo-González, Changjiang Zhao, Chun-Yip Tong, Changhao Li, Songxiao Zhong, Zhiyang Liu, Kaili Xie, Jiaying Zhu, Zhongshou Wu, Xu Peng, Yannick Jacob, Scott D. Michaels, Steven E. Jacobsen, Xiuren Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract The H3 methyltransferases ATXR5 and ATXR6 deposit H3.1K27me1 to heterochromatin to prevent genomic instability and transposon re-activation. Here, we report that atxr5 atxr6 mutants display robust resistance to Geminivirus. The viral resista
Externí odkaz:
https://doaj.org/article/8592bad5b0d24d13a6cc15d3c8d43320
Publikováno v:
Epigenomes, Vol 8, Iss 3, p 33 (2024)
Proteins are localized and concentrated at cellular and genomic locations for specific and efficient functions. Efforts to understand protein accumulation in eukaryotic organisms have primarily focused on multivalent interactions between intrinsicall
Externí odkaz:
https://doaj.org/article/c7b00d65d115467d8cb824a51a560439
Autor:
Zheng Li, Ming Wang, Zhenhui Zhong, Javier Gallego-Bartolomé, Suhua Feng, Yasaman Jami-Alahmadi, Xinyi Wang, James Wohlschlegel, Sylvain Bischof, Jeff A. Long, Steven E. Jacobsen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract MORPHEUS’ MOLECULE1 (MOM1) is an Arabidopsis factor previously shown to mediate transcriptional silencing independent of major DNA methylation changes. Here we find that MOM1 localizes with sites of RNA-directed DNA methylation (RdDM). Tet
Externí odkaz:
https://doaj.org/article/a9ef9968972e4c4d834f28a8b57d10d9
Autor:
Zhenhui Zhong, Yan Xue, C. Jake Harris, Ming Wang, Zheng Li, Yunqing Ke, Mukun Liu, Jessica Zhou, Yasaman Jami-Alahmadi, Suhua Feng, James A. Wohlschlegel, Steven E. Jacobsen
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background The microrchidia (MORC) proteins are a family of evolutionarily conserved GHKL-type ATPases involved in chromatin compaction and gene silencing. Arabidopsis MORC proteins act in the RNA-directed DNA methylation (RdDM) pathway, whe
Externí odkaz:
https://doaj.org/article/36717267e0554e1a8f34782f596b8a07
Autor:
Ming Wang, Zhenhui Zhong, Javier Gallego-Bartolomé, Suhua Feng, Yuan-Hsin Shih, Mukun Liu, Jessica Zhou, John Curtis Richey, Charmaine Ng, Yasaman Jami-Alahmadi, James Wohlschlegel, Keqiang Wu, Steven E. Jacobsen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
TRB proteins have been shown to recruit PRC2 for H3K27me3 deposition. This work shows that TRBs also recruit JMJ14 to remove H3K4me3, demonstrating that TRBs silence the target genes via a combinatorial histone modification mechanism.
Externí odkaz:
https://doaj.org/article/bc9ef621c18d4d34ba18699e910259e6
Autor:
Kira M. Veley, Kiona Elliott, Greg Jensen, Zhenhui Zhong, Suhua Feng, Marisa Yoder, Kerrigan B. Gilbert, Jeffrey C. Berry, Zuh-Jyh Daniel Lin, Basudev Ghoshal, Javier Gallego-Bartolomé, Joanna Norton, Sharon Motomura-Wages, James C. Carrington, Steven E. Jacobsen, Rebecca S. Bart
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Activating the expression of host susceptibility (S) genes is one of the strategies plant pathogens employed to promote infection of their host. Here, the authors show that targeted methylation at the TAL20 effector binding element of the cassava SWE
Externí odkaz:
https://doaj.org/article/e7d105312d684276a6638467e05b4c57
Autor:
Zhenhui Zhong, Yafei Wang, Ming Wang, Fan Yang, Quentin Angelo Thomas, Yan Xue, Yaxin Zhang, Wanlu Liu, Yasaman Jami-Alahmadi, Linhao Xu, Suhua Feng, Sebastian Marquardt, James A. Wohlschlegel, Israel Ausin, Steven E. Jacobsen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Histone chaperones and chromatin remodelers control nucleosome dynamics. Here the authors show that the Arabidopsis ASF1 chaperone primarily supplies histone variants to the HIRA complex to ensure proper epigenetic gene regulation.
Externí odkaz:
https://doaj.org/article/48f202d094e446e09e9606a9f5b188d8
Autor:
Yi-Wen Lim, Ben N. Mansfeld, Pascal Schläpfer, Kerrigan B. Gilbert, Narayanan N. Narayanan, Weihong Qi, Qi Wang, Zhenhui Zhong, Adam Boyher, Jackson Gehan, Getu Beyene, Zuh-Jyh Daniel Lin, Williams Esuma, Suhua Feng, Christelle Chanez, Nadine Eggenberger, Gerald Adiga, Titus Alicai, Steven E. Jacobsen, Nigel J. Taylor, Wilhelm Gruissem, Rebecca S. Bart
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Cassava mosaic disease is caused by geminiviruses and suppresses cassava yields throughout the tropics. Here, the authors show that mutations in MePOLD1, encoding DNA polymerase δ subunit 1, co-segregate with CMD2, the major source of genetic resist
Externí odkaz:
https://doaj.org/article/0325f4ce39364271a1f8c5b5c121c20c
Autor:
Jorge Hernández-García, Borja Diego-Martin, Peggy Hsuanyu Kuo, Yasaman Jami-Alahmadi, Ajay A. Vashisht, James Wohlschlegel, Steven E. Jacobsen, Miguel A. Blázquez, Javier Gallego-Bartolomé
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
The ancestral history of SWI/SNF subunits, responsible for nucleosome positioning, are explored in this work, revealing a plant SWI/SNF complex similar to the animal BAF subclass.
Externí odkaz:
https://doaj.org/article/67661939e7134b0f832753801a3f1631