Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Steven DellaRocca"'
Autor:
Jing Wang, Ali Fattaey, Jaye L. Viner, David P. Tuck, Troy Patterson, Guang-Xin Xu, Anna W. Ma, Maria Elena S. Samson, Steven Dellarocca, Mylissa A. Borek, Ruzanna Atoyan, Kaiming Sun
Supplement Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23bc19b6434feb007149d6b2bfe6b14d
https://doi.org/10.1158/1535-7163.22503454
https://doi.org/10.1158/1535-7163.22503454
Autor:
Jing Wang, Ali Fattaey, Jaye L. Viner, David P. Tuck, Troy Patterson, Guang-Xin Xu, Anna W. Ma, Maria Elena S. Samson, Steven Dellarocca, Mylissa A. Borek, Ruzanna Atoyan, Kaiming Sun
Supplemental Figure S1. Protein level changes induced by CUDC-907, panobinostat, or pictilisib in MYC-altered DLBCL cell lines; Supplemental Figure S2. CUDC-907 induced changes in WSU DLCL2 cells; Supplemental Figure S3. CUDC-907 changes the mRNA exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0819bb72cc77df80bf2d29af33bb24d0
https://doi.org/10.1158/1535-7163.22503451.v1
https://doi.org/10.1158/1535-7163.22503451.v1
Autor:
Maurizio Voi, Xiong Cai, Hai-Xiao Zhai, Mylissa Borek, Steven DellaRocca, Anna Wai See Ma, Brian Zifcak, Maria Samson, Ling Yin, Hui Qu, Ruzanna Atoyan, Guang-Xin Xu, Jing Wang, Da-Gong Wang, Rudi Bao, Cheng-Jung Lai, Changgeng Qian
PDF file, 348KB, Figure S1. Synergy between PI3K and HDAC pathway inhibition. Figure S2. CUDC-907 increases acetylation of histone H3 in cultured cancer cells. Figure S3. CUDC-907 increases tubulin acetylation in cultured cancer cells. Figure S4. CUD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32848b021e6bbc17f583b7bdf8d37c66
https://doi.org/10.1158/1078-0432.22445738.v1
https://doi.org/10.1158/1078-0432.22445738.v1
Autor:
Maurizio Voi, Xiong Cai, Hai-Xiao Zhai, Mylissa Borek, Steven DellaRocca, Anna Wai See Ma, Brian Zifcak, Maria Samson, Ling Yin, Hui Qu, Ruzanna Atoyan, Guang-Xin Xu, Jing Wang, Da-Gong Wang, Rudi Bao, Cheng-Jung Lai, Changgeng Qian
Purpose: Given that histone deacetylase (HDAC) inhibitors are known to induce multiple epigenetic modifications affecting signaling networks and act synergistically with phosphatidylinositol 3-kinase (PI3K) inhibitors, we developed a strategy to simu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57468279c708b76d5357a1cc33f8026e
https://doi.org/10.1158/1078-0432.c.6520553
https://doi.org/10.1158/1078-0432.c.6520553
Autor:
Guang-Xin Xu, Mylissa Borek, Anna W. Ma, Jing Wang, Steven DellaRocca, Maria Samson, Troy Patterson, Kaiming Sun, David Tuck, Ruzanna Atoyan, Jaye L. Viner, Ali Fattaey
Publikováno v:
Molecular Cancer Therapeutics. 16:285-299
Upregulation of MYC is a common driver event in human cancers, and some tumors depend on MYC to maintain transcriptional programs that promote cell growth and proliferation. Preclinical studies have suggested that individually targeting upstream regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38efec963ed8b4e3240d982b5006d6b
https://doi.org/10.1158/1535-7163.mct-16-0390
https://doi.org/10.1158/1535-7163.mct-16-0390
Autor:
Hongwei Wang, Anas Younes, Steven DellaRocca, Zhidong Zhang, David Tuck, Ruzanna Atoyan, Jefferson Parker, Matthew A. Lunning, Krish Patel, Maria Samson, Holly Modafferi, Guang-Xin Xu, Duncan Whitney, Mylissa Borek, Anna W. Ma, Robert N Booher, Grzegorz S. Nowakowski
Publikováno v:
Blood. 132:4168-4168
Background: IRAK4 kinase activity is required for toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling in a variety of myeloid and lymphoid cell types. Recruitment of IRAK4 to these receptors and its subsequent activation is facilita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae928a5d63168393130cbba0eaae5383
https://doi.org/10.1182/blood-2018-99-117383
https://doi.org/10.1182/blood-2018-99-117383
Autor:
Steven DellaRocca, Maria Samson, Mitchell Keegan, Rudi Bao, Carmen V. Pepicelli, Dagong Wang, Haixiao Zhai, Guang-Xin Xu, Brian Zifcak, Jing Wang, Cheng-Jung Lai, Changgeng Qian, Xu Tao, Xiong Cai, Ruzanna Atoyan, William E. Munger, Ling Yin, Jeffrey Forrester, Hui Qu
Publikováno v:
Cancer Research. 70:3647-3656
Receptor tyrosine kinase inhibitors have recently become important therapeutics for a variety of cancers. However, due to the heterogeneous and dynamic nature of tumors, the effectiveness of these agents is often hindered by poor response rates and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e793bf56c0a8ec647e9fa9ebb0eab0ec
https://doi.org/10.1158/0008-5472.can-09-3360
https://doi.org/10.1158/0008-5472.can-09-3360
Autor:
Garrett W. Rhyasen, Mylissa Borek, David Tuck, Ali Fattaey, Kaiming Sun, Steven DellaRocca, Ruzanna Atoyan
Publikováno v:
Blood. 128:4184-4184
CUDC-907 is a first-in-class, oral, dual inhibitor of Class I and II HDAC, as well as Class I PI3K enzymes. Specifically, CUDC-907 is designed to inhibit HDACs 1, 2, 3, 6 and 10 and PI3K-alpha, delta and beta isoform. Preclinical studies demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9311bacfea5c1fe788296e616fa03e25
https://doi.org/10.1182/blood.v128.22.4184.4184
https://doi.org/10.1182/blood.v128.22.4184.4184
Autor:
Mylissa Borek, Maria Samson, Ali Fattaey, Ruzanna Atoyan, Guang-Xin Xu, David Tuck, Troy Patterson, Jing Wang, Anna W. Ma, Jaye L. Viner, Steven DellaRocca, Kaiming Sun
Publikováno v:
Cancer Research. 76:4634-4634
MYC family genes are among the most frequently deregulated oncogenic drivers in human cancer. Pharmacologic inhibition of HDAC activity and blockade of the PI3K pathway have both been shown to suppress MYC-induced transcription. HDAC activity is crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcfc7f9b77f049796114f3cd4e01086e
https://doi.org/10.1158/1538-7445.am2016-4634
https://doi.org/10.1158/1538-7445.am2016-4634
Autor:
Maurizio Voi, Guang-Xin Xu, Brian Zifcak, Anna Wai See Ma, Dagong Wang, Steven DellaRocca, Rudi Bao, Maria Samson, Cheng-Jung Lai, Hui Qu, Mylissa Borek, Haixiao Zhai, Ling Yin, Xiong Cai, Ruzanna Atoyan, Changgeng Qian, Jing Wang
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 18(15)
Purpose: Given that histone deacetylase (HDAC) inhibitors are known to induce multiple epigenetic modifications affecting signaling networks and act synergistically with phosphatidylinositol 3-kinase (PI3K) inhibitors, we developed a strategy to simu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30856ca7850cffb57cfbf533291632a
https://pubmed.ncbi.nlm.nih.gov/22693356
https://pubmed.ncbi.nlm.nih.gov/22693356