Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Steven D. Salhanick"'
Autor:
Jessica Peck, Steven D. Salhanick
Publikováno v:
Toxicology Communications, Vol 5, Iss 1, Pp 82-84 (2021)
AbstractMidodrine is a prodrug metabolized to the peripheral acting alpha agonist desglymidodrine and is used to treat orthostatic hypotension. Reports of overdose are rare, consequently there is little guidance regarding treatment of overdose. We re
Externí odkaz:
https://doaj.org/article/fb1c22e72be54238953bab5e0f6afa3a
Autor:
Patrick Lee, Steven D. Salhanick
Publikováno v:
Clinical Practice and Cases in Emergency Medicine, Vol 4, Iss 1 (2020)
Carbon monoxide (CO) poisoning is typically treated by administration of oxygen via non-rebreather mask (NRB). High-flow nasal cannula (HFNC) is an alternative to NRB in a variety of disease states. We report a case of the novel use of HFNC in the tr
Externí odkaz:
https://doaj.org/article/fc9c3c8a6d124e2fb71f4dad341a3150
Publikováno v:
Clinical toxicology (Philadelphia, Pa.). 58(8)
Introduction: This study examines the metabolomic profile in humans following acetaminophen (APAP) induced subclinical hepatoxicity in the presence and absence of propylene glycol (PG), a cytochrom...
Publikováno v:
Journal of clinical pharmacology. 59(1)
Acetaminophen (APAP)-induced liver injury is initiated by metabolism of APAP by the cytochrome P-450 (CYP) system, primarily CYP2E1. We previously demonstrated CYP inhibition following administration of a liquid APAP formulation containing propylene
Publikováno v:
Journal of Medical Toxicology. 11:132-136
A 24-year-old female with idiopathic end-stage renal disease (ESRD) for the past 8 months, currently on home peritoneal dialysis, presented to an outside hospital with progressive confusion, tremulousness, clumsiness and a sensation of being “outsi
Effect of Excipients on Acetaminophen Metabolism and Its Implications for Prevention of Liver Injury
Autor:
Shiva Guatam, Steven D. Salhanick, Michael Ganetsky, Mark Böhlke, Luis R. Pereira, David A. Williams, Barbara LeDuc
Publikováno v:
The Journal of Clinical Pharmacology. 53:413-420
Acetaminophen poisoning is the most frequent cause of acute hepatic failure in the US. Toxicity requires reductive metabolism of acetaminophen, primarily via CYP2E1. Liquid acetaminophen preparations contain propylene glycol, a common excipient that
Autor:
Moritz Schmelzle, Wolfram T. Knoefel, Eva Csizmadia, Martina Nowak, Steven D. Salhanick, Shu Bian, Günter Fürst, Simon C. Robson, Yan Wu, Vasilis Toxavidis, Constanze Duhme, Lihui Han, Wolfgang G. Junger, Yu Chen, Seth J. Karp, Jan Schulte am Esch
Publikováno v:
Annals of Surgery. 257:693-701
To study molecular mechanisms involved in hematopoietic stem cell (HSC) mobilization after liver resection and determine impacts on liver regeneration.Extracellular nucleotide-mediated cell signaling has been shown to boost liver regeneration. Ectonu
Autor:
Steven D. Salhanick, Jan am Schulte Esch, Martina Nowak, Katrin Splith, Vasilis Toxavidis, Simon C. Robson, Sven Jonas, Miroslaw Kornek, Detlef Schuppan, Michael W. Donnino, Caitlin Jones-Bamman, Moritz Schmelzle, Lihui Han, Lars W. Andersen
Publikováno v:
Schmelzle, M, Splith, K, Wiuff Andersen, L, Kornek, M, Schuppan, D, Jones-Bamman, C, Nowak, M, Toxavidis, V, D. Salhanick, S, Han, L, am Schulte Esch, J, Jonas, S, W. Donnino, M & C. Robson, S 2013, ' Increased plasma levels of microparticles expressing CD39 and CD133 in acute liver injury ', Transplantation, bind 95, nr. 1, s. 62-9 . https://doi.org/10.1097/TP.0b013e318278d3cd
BACKGROUND:We have previously demonstrated that CD133 and CD39 are expressed by hematopoietic stem cells (HSC), which are mobilized after liver injury and target sites of injury, limit vascular inflammation, and boost hepatic regeneration. Plasma mic
Publikováno v:
The Journal of Emergency Medicine. 44:116-121
Background Diagnosis and management of Amanita mushroom poisoning is a challenging problem for physicians across the United States. With 5902 mushroom exposures and two resultant deaths directly linked to Amanita ingestion in 2009, it is difficult fo
Publikováno v:
Journal of Medical Toxicology. 7:281-287
Dabigatran (Pradaxa) is a competitive direct thrombin inhibitor approved by the US FDA for prevention of embolic stroke in patients with nonvalvular atrial fibrillation. Dabigatran has a pharmacokinetic profile that produces predictable anticoagulati