Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Steven D. Klaassen"'
Publikováno v:
Toxicology Letters. 324:86-94
Organophosphorus nerve agents (NA) inhibit acetylcholinesterase (AChE) which results in the over-stimulation of both the central and peripheral nervous systems, creating a toxic syndrome that can be lethal if left untreated (Cannard, 2006). It is sta
Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigs
Autor:
Jeff D. Shearer, Marloes J.A. Joosen, Alex S. Cornelissen, Elwin Verheij, Steven D. Klaassen, Mario H. Skiadopoulos, Laura Cochrane, Tomas van Groningen
Publikováno v:
Chemico-Biological Interactions. 296:34-42
The efficacy and pharmacokinetics of the aqueous co-formulation contents of the Trobigard™ (atropine sulfate, obidoxime chloride) auto-injector were evaluated in a sarin exposed guinea pig model. Two subcutaneous (sc) sarin challenge doses were eva
Autor:
Timo Wille, Marloes J.A. Joosen, Steven D. Klaassen, Florian Nachon, Hans M. de Bruijn, Duurt P. W. Alkema, Franz Worek, Martijn C. de Koning, Marco van Grol
Publikováno v:
Journal of Medicinal Chemistry. 60:9376-9392
Recently, a new class of reactivators of chemical warfare agent inhibited acetylcholinesterase (AChE) with promising in vitro potential was developed by the covalent linkage of an oxime nucleophile and a peripheral site ligand. However, the complexit
Autor:
Marloes J.A. Joosen, Sara Bohnert, Steven D. Klaassen, Tomas van Groningen, Alex S. Cornelissen, Laura Cochrane, Vladimir Savransky, John Barry, Jiska Kentrop
Publikováno v:
Regulatory Toxicology and Pharmacology. 119:104823
Nerve agent exposure is generally treated by an antidote formulation composed of a muscarinic antagonist, atropine sulfate (ATR), and a reactivator of acetylcholinesterase (AChE) such as pralidoxime, obidoxime (OBI), methoxime, trimedoxime or HI-6 an
Autor:
Marloes J.A. Joosen, Tomas van Groningen, Steven D. Klaassen, Alex S. Cornelissen, Sara Bohnert
Publikováno v:
Toxicology and Applied Pharmacology. 396:114994
Anticholinergic treatment is key for effective medical treatment of nerve agent exposure. Atropine is included at a 2 mg intramuscular dose in so-called autoinjectors designed for self- and buddy-aid. As patient cohorts are not available, predicting
Autor:
Steven D. Klaassen, Alex S. Cornelissen, Peter Hesseling, Gideon F. Meerhoff, Marloes J.A. Joosen, Paul J. Lucassen, Stefanie M. Vester
Publikováno v:
Journal Neurotoxology, 68, 167-176
Neurotoxicology, 68, 167-176. Elsevier
Neurotoxicology, 68, 167-176. Elsevier
Organophosphate (OP) induced seizures are commonly treated with anticholinergics, oximes and anticonvulsants. Inhibition of P-glycoprotein (PgP) has been shown to enhance the efficacy of nerve agent treatment in soman exposed rats. In the present stu
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http://resolver.tudelft.nl/uuid:1156eb78-3135-4a6a-917d-a346fbdeee86
http://resolver.tudelft.nl/uuid:1156eb78-3135-4a6a-917d-a346fbdeee86
Autor:
Marloes J.A. Joosen, Jouk Hamelink, Stefanie M. Vester, Roland M. van den Berg, Steven D. Klaassen
Publikováno v:
Chemico-biological interactions. 259
One of the shortcomings of current treatment of nerve agent poisoning is that not all drugs effectively penetrate the blood-brain barrier (BBB), whereas most nerve agents easily do. P-glycoprotein (Pgp) efflux transporters at the BBB may contribute t