Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Steven D. Chessler"'
Autor:
Andrea J. Glenn, Jie Li, Kenneth Lo, David J.A. Jenkins, Beatrice A. Boucher, Anthony J. Hanley, Cyril W.C. Kendall, Aladdin H. Shadyab, Lesley F. Tinker, Steven D. Chessler, Barbara V. Howard, Simin Liu, John L. Sievenpiper
Publikováno v:
Diabetes care. 46(1)
OBJECTIVE A plant-based dietary pattern, the Portfolio Diet, has been shown to lower LDL cholesterol and other cardiovascular disease risk factors. However, no study has evaluated the association of this diet with incident type 2 diabetes. RESEARCH D
Autor:
Joseph Muenzer, Paul Harmatz, Barbara K. Burton, Deepa Rajan, Simon A. Jones, Steven D. Chessler, Natalie Engmann, Adam Scheller, Charlene Chen, Rupa Caprihan, Akhil Bhalla, Tony Hung, Jason Nachtigall, Imanol Zubizarreta, Angela Kay, Simona Costanzo, Jeffrey M. Harris, Yuda Zhu, Peter Chin, Matthew D. Troyer, Carole Ho, Anna I. Bakardjiev
Publikováno v:
Molecular Genetics and Metabolism. 138:107231
Autor:
Aristides K Maniatis, Samuel J Casella, Ulhas M Nadgir, Paul L Hofman, Paul Saenger, Elena D Chertock, Elena M Aghajanova, Maria Korpal-Szczyrska, Elpis Vlachopapadopoulou, Oleg Malievskiy, Tetyana Chaychenko, Marco Cappa, Wenjie Song, Meng Mao, Per Holse Mygind, Alden R Smith, Steven D Chessler, Allison S Komirenko, Michael Beckert, Aimee D Shu, Paul S Thornton
Publikováno v:
The Journal of clinical endocrinology and metabolism. 107(7)
Purpose The objectives of the ongoing, Phase 3, open-label extension trial enliGHten are to assess the long-term safety and efficacy of weekly administered long-acting growth hormone lonapegsomatropin in children with growth hormone deficiency. Metho
Autor:
Paul Saenger, Ulhas Nadgir, Paul Hofman, Paul Thornton, Elena D Chertok, Elena M Aghajanova, Maria Korpal-Szczyrska, Elpis Vlachopapadopoulou, Oleg Malievskiy, Tetyana Chaychenko, Marco Cappa, Wenjie Song, Meng Mao, Steven D Chessler, Allison S Komirenko, Michael Beckert, Aimee D Shu, Aristides K Maniatis
Publikováno v:
Journal of the Endocrine Society. 6:A645-A645
Background Once-weekly lonapegsomatropin (TransCon hGH) is a long-acting prodrug of somatropin, recently approved for the treatment of pediatric growth hormone deficiency (GHD) by the US FDA. In the pivotal 52-week phase 3 heiGHt trial and the 26-wee
Autor:
Aristides K. Maniatis, Ulhas Nadgir, Paul Saenger, Kent L. Reifschneider, Jennifer Abuzzahab, Larry Deeb, Larry A. Fox, Katie A. Woods, Wenjie Song, Meng Mao, Steven D. Chessler, Allison S. Komirenko, Aimee D. Shu, Samuel J. Casella, Paul S. Thornton
Publikováno v:
Hormone research in paediatrics. 95(3)
Introduction: The phase 3 fliGHt Trial evaluated the safety and tolerability of once-weekly lonapegsomatropin, a long-acting prodrug, in children with growth hormone deficiency (GHD) who switched from daily somatropin therapy to lonapegsomatropin. Me
Autor:
Linlin Zhong, Tsung-Yin J Yeh, Jun Hao, Nasim Pourtabatabaei, Sushil K Mahata, Jianhua Shao, Steven D Chessler, Nai-Wen Chi
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122948 (2015)
The poly-ADP-ribosylation (PARsylation) activity of tankyrase (TNKS) regulates diverse physiological processes including energy metabolism and wnt/β-catenin signaling. This TNKS activity uses NAD+ as a co-substrate to post-translationally modify var
Externí odkaz:
https://doaj.org/article/7c9942a84de9495e9f26bf9d7e80d347
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65711 (2013)
Neuroligin-2 is a transmembrane, cell-surface protein originally identified as an inhibitory synapse-associated protein in the central nervous system. Neuroligin-2 is also present on the pancreatic beta-cell surface, and there it engages in transcell
Externí odkaz:
https://doaj.org/article/fac5dc2b69d44f4c8eb7399da9b3e745
Autor:
Abraham P. Lee, C Zhang, S H Lee, D Lee, Derek Vallejo, Crystal E. Rapier, Steven D. Chessler
Publikováno v:
Vallejo, D; Lee, SH; Lee, D; Zhang, C; Rapier, C; Chessler, SD; et al.(2017). Cell-sized lipid vesicles for cell-cell synaptic therapies.. Technology, 5(4), 201-213. doi: 10.1142/S233954781750011X. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/53f3065v
Technology, vol 5, iss 4
Technology, vol 5, iss 4
Cell-sized lipid vesicles (CLVs) have shown great promise for therapeutic and artificial cell applications, but their fragility and short shelf life has hindered widespread adoption and commercial viability. We present a method to circumvent the stor
Autor:
Andrea J. Glenn, Barbara V. Howard, Steven D. Chessler, Beatrice A. Boucher, Aladdin Shadyab, Lesley F. Tinker, Kenneth Lo, Simin Liu, Anthony J. Hanley, David J.A. Jenkins, Cyril W.C. Kendall, John L. Sievenpiper
Publikováno v:
Curr Dev Nutr
OBJECTIVES: To assess the association of the plant-based cholesterol-lowering diet, the Portfolio Diet, with incident type 2 diabetes in women. METHODS: We followed 147,732 postmenopausal women initially free of diabetes in the Women's Health Initiat
Autor:
Samuel J. Casella, Aimee D Shu, Paul L. Hofman, Ulhas M Nadgir, Paul S. Thornton, Wenjie Song, Allison Komirenko, Michael Beckert, Elena Aghajanova, Steven D Chessler, Aristides K Maniatis, Elena Chertok, Meng Mao, Paul Saenger
Publikováno v:
Journal of the Endocrine Society
Background: Once-weekly TransCon hGH (lonapegsomatropin) is an investigational long-acting prodrug of somatropin in development for GHD. In the pivotal 52-week phase 3 heiGHt trial, lonapegsomatropin demonstrated superior annualized height velocity (