Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Steven D Hughes"'
Autor:
Cecile M Krejsa, Rick D Holly, Mark Heipel, Ken M Bannink, Rebecca Johnson, Richard Roque, Jane Heffernan, Julie Hill, Lay Chin, Felecia Wagener, Faith Shiota, Katherine Henderson, Pallavur V Sivakumar, Hong-Ping Ren, Fariba Barahmand-Pour, Don Foster, Chris Clegg, Wayne Kindsvogel, Rafael Ponce, Steven D Hughes, Kim Waggie
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67256 (2013)
Rituximab, a monoclonal antibody targeting CD20 on B cells, is currently used to treat many subtypes of B cell lymphomas. However, treatment is not curative and response rates are variable. Recombinant interleukin-21 (rIL-21) is a cytokine that enhan
Externí odkaz:
https://doaj.org/article/75eba1524ef24901bc6062fdb1f8b56a
Autor:
Michael G. Dodds, Klaus Stensgaard Frederiksen, John A. Thompson, Kresten Skak, Steven D. Hughes, Dorthe Lundsgaard, Lasse Hansen
Publikováno v:
Cancer Immunology, Immunotherapy. 58:843-854
Recombinant interleukin-21 (rIL-21) is an immune stimulating cytokine recently tested in two Phase 1 trials for immune responsive cancers. A secondary objective of these trials was to characterize pharmacodynamic responses to rIL-21 in patients. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345b0bf7092c6f9265fd5e097330108b
https://doi.org/10.1007/s00262-008-0600-8
https://doi.org/10.1007/s00262-008-0600-8
Autor:
Guihua Jiang, Alfred E. Chang, Qiao Li, Takekazu Iuchi, Jianhua Huang, Steven D. Hughes, Mu Li, Bruce G. Redman, Seagal Teitz-Tennenbaum
Publikováno v:
Cancer Research. 68:4431-4441
Interleukin (IL)-21 modulates T-cell–associated, B-cell–associated, and natural killer cell–associated immunity. However, the potential of IL-21 to simultaneously stimulate cellular and humoral antitumor responses and the mechanisms involved ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83cbe503b4e19a15e57ed4c26f328854
https://doi.org/10.1158/0008-5472.can-07-5530
https://doi.org/10.1158/0008-5472.can-07-5530
Autor:
Edward M. Rubin, Steven D. Hughes
Publikováno v:
Clinical Genetics. 52:361-366
Despite the importance of lipoprotein(a) [Lp(a)] as an atherogenic risk factor, very little information, especially from in vivo studies, is available concerning which structural features of apo(a) contribute to the interactions of Lp(a) with the ves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ab4af7292b7f251f28bc94adf04aa2
https://doi.org/10.1111/j.1399-0004.1997.tb04354.x
https://doi.org/10.1111/j.1399-0004.1997.tb04354.x
Autor:
Dorthe Lundsgaard, Lasse Hansen, Grant A. McArthur, Ian D. Davis, Thomas Lindebo Holm, Andreas Petri, Klaus Stensgaard Frederiksen, Brite K Skrumsager, Jeremy A Freeman, Steven D. Hughes, Kresten Skak
Publikováno v:
Cancer Immunology, Immunotherapy
Purpose Human interleukin-21 (IL-21) is a class I cytokine previously reported in clinical studies on immune responsive cancers. Here we report the effects of systemic IL-21 therapy on the immune system in two phase 1 trials with this novel cytokine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b7af9bd9c329e42a4d34d5177790b9
http://europepmc.org/articles/PMC2491425
http://europepmc.org/articles/PMC2491425
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 3:209-234
The immune system has evolved highly effective mechanisms of surveillance and defense against foreign pathogens, and is also thought to act in surveillance and suppression of cancer. Thus, a predominant goal of immune system-based therapies is to nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d6db73217150da4c7d6df641b9e7d1
https://doi.org/10.1517/17425255.3.2.209
https://doi.org/10.1517/17425255.3.2.209
Autor:
Matthew Yeh, Steven D. Hughes, Hong-Ping Ren, Thomas E. Palmer, Melissa M. Odell, Jean S. Campbell, Renay L. Bauer, Debra G. Gilbertson, Harald S. Haugen, Aaron C. Haran, Nelson Fausto, Matthew S. Holdren
Publikováno v:
Proceedings of the National Academy of Sciences. 102:3389-3394
Members of the platelet-derived growth factor (PDGF) ligand family are known to play important roles in wound healing and fibrotic disease. We show that both transient and stable expression of PDGF-C results in the development of liver fibrosis consi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75058c0045218cb3ccb0453c6848b95
https://doi.org/10.1073/pnas.0409722102
https://doi.org/10.1073/pnas.0409722102
Autor:
J. Claus, J. Berry, Andrew L. Feldhaus, Steven D. Hughes, D.L. Thompson, Pamela Shea, David R. Eyre, Hong-Ping Ren, Emma E. Moore, Tom Bukowski, Harold Storey, M.S. Holdren, K.D. Lum, Susan D. Holderman, Jeff L. Ellsworth, Lena Yao, Cindy A. Sprecher, Fenella C. Raymond, Kimberly S. Waggie, Russell J. Fernandes
Publikováno v:
Osteoarthritis and Cartilage. 10:308-320
Objective The aim of this study was to examine the effects of recombinant human Fgf18 on chondrocyte proliferation and matrix production in vivo and in vitro . In addition, the expressions of Fgf18 and Fgf receptors ( Fgfr ) in adult human articular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18df2c0e430123c82dd9b5ed44329996
https://doi.org/10.1053/joca.2002.0514
https://doi.org/10.1053/joca.2002.0514
Autor:
Edward M. Rubin, John R. Morrison, Trudy M. Forte, Steven D. Hughes, Chris Paszty, Mary E. Stevens, James Scott
Publikováno v:
Proceedings of the National Academy of Sciences. 93:7154-7159
RNA editing in the nucleus of higher eukaryotes results in subtle changes to the RNA sequence, with the ability to effect dramatic changes in biological function. The first example to be described and among the best characterized, is the cytidine-to-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6188f357dd5f0333f7eba675ebdf9bc
https://doi.org/10.1073/pnas.93.14.7154
https://doi.org/10.1073/pnas.93.14.7154
Autor:
Kelly Byrnes-Blake, Matthew S. Holdren, Susan Pedersen, Dennis M. Miller, Rafael Ponce, Steven D. Hughes, Kimberly S Waggie
Publikováno v:
International journal of toxicology. 31(4)
Interleukin-21 (IL-21), a pleiotropic immunostimulatory type I cytokine, has anticancer effects in animal models. Preclinical studies designed to assess the safety of recombinant human IL-21 (rIL-21) for use in phase I oncology studies are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4514db87a4a65d0ea7b9ba41401c7010
https://pubmed.ncbi.nlm.nih.gov/22723515
https://pubmed.ncbi.nlm.nih.gov/22723515