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Autor:
Xiaojuan Li, Steven Chico, Jason K. Cheung, Xiaoyu Yang, Soundara Soundararajan, Umesh Kishnani, Jorge Alexander Pavon, Daisy Richardson, Huijuan Li, Mohammed Shameem
Publikováno v:
Journal of Chromatography A. 1431:154-165
Analysis of oxidation of monoclonal antibodies (mAbs) in most cases relies on peptide mapping and LC-MS, which is time consuming and labor-intensive. A robust chromatography based method that is able to resolve and quantitate mAb oxidation variants d