Výsledky vyhledávání - "Steven Challand"

Novel CCR5 monoclonal antibodies with potent and broad-spectrum anti-HIV activities

Autor: Gabrielle Heilek-Snyder, Jun Zhang, Changhua Ji, Gunthar Achhammer, Nick Cammack, Steven Challand, Ralf Schumacher, Monika Baehner, Surya Sankuratri, Andreas Jekle, Sandra Kroetz, Michael Brandt, Lisa Zautke, Stephan Schwoerer, Marianna Dioszegi, Yun Chen

Publikováno v: Antiviral Research. 74:125-137

To identify monoclonal antibodies (mAbs) with high potency and novel recognition sites, more than 25,000 of mouse hybridomas were screened and 4 novel anti-human CCR5 mAbs ROAb12, ROAb13, ROAb14, and ROAb18 showing potent activity in cell-cell fusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed38cb9db5052ebbfe98f57a06c9250
https://doi.org/10.1016/j.antiviral.2006.11.003

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An ex vivo potency assay to assess active drug levels of a GLP-1 agonistic peptide during preclinical safety studies

Autor: Apollon Papadimitriou, Lutz Müller, Julia Heinrich, Martin Schäfer, Steven Challand, Katja Heinig, Dominik Hainzl, Sabine Bader, Eginhard Schick

Publikováno v: Bioanalysis. 7(24)

Background: During development of biologics, safety and efficacy assessments are often hampered by immune responses to the treatment. To assess active exposure of a drug peptide in a toxicology study, we developed an ex vivo potency assay which compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f0a2addfbe718f8d64655a6bbfd86c
https://pubmed.ncbi.nlm.nih.gov/26440381

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