Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Steven C. Shoner"'
Autor:
David A. Mankoff, Steven C. Shoner, Jeanne M. Link, Mark Muzi, Lucy Sasongko, Ann C. Collier, Xiaodong Yang, Jashvant D. Unadkat
Publikováno v:
Clinical Pharmacology & Therapeutics. 77:503-514
Background Numerous knockout mouse studies have revealed that P-glycoprotein (P-gp) significantly limits drug distribution across the mouse blood-brain barrier (BBB). To determine the importance of P-gp at the human BBB, we developed a state-of-the-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8033877dacbf88ef1855b58bb6a45cad
https://doi.org/10.1016/j.clpt.2005.01.022
https://doi.org/10.1016/j.clpt.2005.01.022
Publikováno v:
Inorganic Chemistry. 43:7726-7734
Oxidations of a trigonal-bipyramidal, high-spin Ni(II) dithiolate complex of a pentadentate, N3S2-donor ligand, N1,N9-bis(imino-2-mercaptopropane)-1,5,9-triazanonane) nickel(II), and the structurally analogous Zn(II) complex, lead to oxidations of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e0ee11d6b0ae3093dbe5341385dba5
https://doi.org/10.1021/ic049110n
https://doi.org/10.1021/ic049110n
Autor:
Julie A. Kovacs, Durrell K. Rittenberg, Reza Loloee, Jason Shearer, Jeffrey J. Ellison, David M. Barnhart, Scott Lovell, Dirk Schweitzer, Steven C. Shoner
Publikováno v:
Inorganic Chemistry. 41:3128-3136
To examine how small structural changes influence the reactivity and magnetic properties of biologically relevant metal complexes, the reactivity and magnetic properties of two structurally related five-coordinate Fe(III) thiolate compounds are compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cd783a2d4dcb815c8c09b753f42cd2
https://doi.org/10.1021/ic0109187
https://doi.org/10.1021/ic0109187
Autor:
Henry L. Jackson, Scott Lovell, Julie A. Kovacs, Jerry A. Cowen, Steven C. Shoner, David M. Barnhart, Durrell K. Rittenberg
Publikováno v:
Inorganic Chemistry. 40:1646-1653
A series of four structurally related cis-dithiolate-ligated Fe(III) complexes, [Fe(III)(DITpy)2]Cl (1), [Fe(III)(DITIm)2]Cl (2), [Fe(III)(ADIT)2]Cl (3), and [Fe(III)(AMIT)2]Cl (4), are described. The structural characterization of 3 as well as the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7dadc80e58370574f12df817a34942
https://doi.org/10.1021/ic001271d
https://doi.org/10.1021/ic001271d
Autor:
Jeffrey J. Ellison, Irene Y. Kung, Andrew M. Nienstedt, Steven C. Shoner, Julie A. Kovacs, David M. Barnhart
Publikováno v:
Inorganic Chemistry. 37:5721-5726
The syntheses and structures of two analogous five-coordinate mixed nitrogen/thiolate-ligated Co2+ and Fe2+ complexes are described and compared to their previously reported Zn2+ and Ni2+ analogues...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8bff3cc73b5a214cc895c7befff16ae
https://doi.org/10.1021/ic980882r
https://doi.org/10.1021/ic980882r
Autor:
Mark J. Nelson, John G. Cummings, Steven C. Shoner, Julie A. Kovacs, Jeffrey J. Ellison, Brent S. Strickler, Robert C. Scarrow
Publikováno v:
Journal of the American Chemical Society. 120:9237-9245
Analysis of the iron K-edge X-ray absorption spectrum (XAS) of the “dark”, inactive form of nitrile hydratase (NHdk) from Rhodococcus sp. R312 confirms a 1:1 stoichiometry of nitric oxide bound to low-spin iron(III). We also report XAS analyses o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dceb853e0b711f7cc370d2fd7d9d7a38
https://doi.org/10.1021/ja973291t
https://doi.org/10.1021/ja973291t
Autor:
Andrew M. Nienstedt, Julie A. Kovacs, Steven C. Shoner, Jerry A. Cowen, David M. Barnhart, Jeffrey J. Ellison
Publikováno v:
Journal of the American Chemical Society. 120:5691-5700
To examine inhibitor binding to an iron site resembling that of the metalloenzyme nitrile hydratase (NHase), a coordinatively unsaturated, five-coordinate FeIII thiolate complex was synthesized, and its reactivity examined. Ferricinium hexafluorophos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2caa18885b450d8166a4b0f62c15fc75
https://doi.org/10.1021/ja973129q
https://doi.org/10.1021/ja973129q
Publikováno v:
AIP Conference Proceedings.
Fluorine-18 is used for many PET radiopharmaceuticals. Theoretically 18F should be carrier free and a good candidate for nanochemistry. However, 18F has 10 to 1000 times more stable fluorine atoms than radioactive atoms. In order to understand the so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87be2a12797fa4f5bdaa51e248391885
https://doi.org/10.1063/1.4773941
https://doi.org/10.1063/1.4773941
Publikováno v:
Inorganic Chemistry. 32:1860-1863
Sulfur-ligated Ni complexes are of interest as active-site models of the Ni-containing enzymes hydrogenase (H[sub 2]-ase), methyl coenzyme M reductase (Me-CoM reductase), and Co-dehydrogenase (CODH). Me-CoM reductase catalyzes the last step in the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b839421d16ce6b1590497c4a949c0a5c
https://doi.org/10.1021/ic00061a052
https://doi.org/10.1021/ic00061a052
Autor:
Philip P. Power, Steven C. Shoner
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62c4b303bfa714beec786d88c19ba00c
https://doi.org/10.1002/chin.199110235
https://doi.org/10.1002/chin.199110235